Dylan Ryan
@RyanLab_MBU
Group leader at MRC mitochondrial biology unit (MBU), University of Cambridge. An immunometabolism enthusiast. 🦋 @ryanlab.bsky.social
📢Last week's #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/20… A large collection of papers & preprints! Highlights (1/n): Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism - a new TCA cycle regulator targeting OGDHC…
Using their knowledge in translational science, @lifearc1 are a charity dedicated to shaping the future for people living with #RareDiseases - making life science life changing - a perfect match as GOLD sponsor for #RAREsummit25 - huge thank you LifeArc! camraredisease.org/raresummit25/
New in @SciImmunology: we provide a multi-pronged dissection of muscle inflammatory responses to acute and chronic endurance exercise and uncover a critical role of Tregs in restraining such responses to promote enhanced performance after training. shorturl.at/cfTX0
UMDF's No-Cost Genetic Testing is available again! All interested patients with suspected #mitochondrialdisease, should register in UMDF's mitoSHARE patient registry to get started! On Genetic Testing Action Day, let's bridge the gaps TOGETHER. Visit umdf.org/genetictesting
Structural basis for promoter recognition and transcription factor binding and release in human mitochondria: Molecular Cell cell.com/molecular-cell…
Galán et al found that #cDC1s are proatherogenic via local #immunity & developed a novel #immunotherapy for #atherosclerosis based on cDC1-targeted lipid #nanoparticles. Learn more at ahajrnls.org/3GVqEZy @Sancholab @SBiomagMfb @aramiro_ramiro @CarregalSusana
The metabolite imidazole propionate from bacteria in gut is linked to type 2 diabetes & cardiovascular disease. This preprint implicates high imidazole propionate levels in Alzheimer's/dementia and show pro-neurodegenerative effects in mice researchsquare.com/article/rs-707…
Excited to share this new work from our lab, led by an exceptional graduate student, Tornike Mamuladze (@tornikemamu), on the role of meningeal mast cells in regulation of brain/dura access points, with implications to CSF flow dynamics and meningitis || authors.elsevier.com/sd/article/S00…
T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below nature.com/articles/s4158…
Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix landscapes” was published today in @emboreports, describing how #neutrophil #metabolism influences niche priming & #metastasis (1/14) embopress.org/doi/full/10.10…
A gut sense for a microbial pattern regulates feeding | Nature share.google/RYo8hlN585Up0P…
NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity @Nature nature.com/articles/s4158…
N-acetylaspartate from fat cells regulates postprandial body temperature go.nature.com/4kU585m
Salmonella Typhi gut invasion drives hypoxic immune subsets associated with disease outcomes nature.com/articles/s4146…
Just out: Latest selection of novel methods for #metabolomics and #lipidomics biomed.news/bims-metlip/20… A collaboration with @Bims_BiomedNews
🎉 The revised version of CORNETO, our unified Python framework for knowledge-driven network inference from omics data, is published in peer reviewed form 🔗 Paper: nature.com/articles/s4225… 📖 News & Views: nature.com/articles/s4225… 💻 Code: corneto.org 🧵 Thread 👇
Journals have transformed into gatekeepers whose judgments determine which science gets seen, and which scientists succeed. Our model eliminates accept/reject decisions and restores autonomy to authors. elifesciences.org/inside-elife/7…
Unraveling mitochondrial pyruvate dysfunction to mitigate hyperlactatemia and lethality in sepsis dlvr.it/TM369d
Today in @CellCellPress we report the use of prime editing to correct several mutations that cause alternating hemiplegia of childhood (AHC), a rare and devastating neurodevelopmental disorder, in patient-derived cells and in two mouse models. drive.google.com/file/d/1ibC50t… 1/10