Thomas Renné
@thomas_renne
Professor of Clinical Chemistry, MD PhD, fascinated in the crosstalk of coagulation and inflammation, factor XII, polyphosphate, vascular biology
Factor XII drives thrombosis but is dispensable for hemostasis, making it an anticoagulant drug target. We show that factor XII–triggered coagulation traps pathogens and limits bacterial dissemination, highlighting a role of prothrombotic mechanisms in innate immunity.
Ausschreibung: W2 Professur für Translationale Präzisionsdiagnostik am UKE
Opportunity for fans of thrombosis and homeostasis. Join our team! nature.com/naturecareers/…
We regret to share that Claire McLintock (@doctormclintock), passed away on December 23, 2022. Claire served the @ISTH in many positions, including as ISTH President from 2018-2020. She was a brilliant, bright light and will be greatly missed. Read more: isth.org/news/626793/Re…
Intrinsic coagulation pathway-mediated thrombin generation in mouse whole blood frontiersin.org/articles/10.33…
Dec 5, 1994. Russia guaranteers the sovereignty of Ukraine (German news)
doi.org/10.1182/blood.… Please enjoy our published article on the mechanistic basis of Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT) and the corresponding commentary in BLOOD #Corona #AstraZeneca
It is well known that factor XII has a critical role in thrombosis sparing hemostasis, however the protease has much broader importance. Thanks to Reiner Mailer and colleagues for providing an update on factor XII-driven vascular inflammatory reactions: authors.elsevier.com/a/1d-8Yc5IDe%7…
Mechanism of VITT In a collaborative effort with Andreas Greinachersr team and many colleagues we have identified the mechanic basis that underlies Vaccine-induced immune thrombotic thrombocytopenia (VITT). The findings will improve patient safety. Enjoy! doi.org/10.1182/blood.…
How clotting starts. Please see our new study on the structure of factor XII activation and its diagnostic implications leading to improved patient care. Enjoy! doi.org/10.1038/s41467… nature.com/articles/s4146…
Mechanism of AstraZeneca-associated thrombosis researchsquare.com/article/rs-440…
Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate | Blood | American Society of Hematology ashpublications.org/blood/article/…
NETs/Factor XII axis in COVID-19. antibody CSL312 might offer a novel therapy in Corona patients. biorxiv.org/content/10.110…
For platelet and coagulation reseacher, please see the new study on platelet polyP: doi.org/10.1182/blood.…