Colm Nestor
@theNestorLab
Associate Professor, DNA Modifications in Cancer Biology, Linköping University, Sweden
Largescale changes in the genome inherited from parents are significant risk factors for pediatric solid tumors, a new Science study finds. The results provide new insights into the genetic underpinnings of pediatric cancers and open doors for improved diagnostic and treatment…
Check out a new Review article on clonal hematopoiesis by Jen Trowbridge and collaborators @NatureCancer doi.org/10.1038/s43018…
Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methylation epigenetic patterns, according to a clinical study that may explain why the condition becomes milder with age. scim.ag/4lc1BQU @ScienceTM
Happy to introduce AlphaGenome, @GoogleDeepMind's new AI model for genomics. AlphaGenome offers a comprehensive view of the human non-coding genome by predicting the impact of DNA variations. It will deepen our understanding of disease biology and open new avenues of research.
🚨Just published in Clinical Epigenetics! 1 in 3 women ≤30 with triple-negative breast cancer (TNBC) carry a hidden BRCA1 epimutation — missed by genetic tests. 🧬 Detected with MethylDetect™ MS-HRM. 👉 doi.org/10.1186/s13148… #BRCA1 #Epigenetics #TNBC #MethylDetect
We are so happy to be on the cover @sarahhoelzl @amycaoart 🎉 The cover depicts the Three Fates, who manipulate the threads of life and death. The Fates are shown as three older women, unraveling the threads of the inactive X chromosome during aging. nature.com/nataging/volum…
❤️Our April issue is out❤️ Read about sex differences in atherosclerosis revealed by single-cell sequencing, how cardiac motion can be generated from electrocardiogram readings, the cardiac side effects of targeting immune checkpoint regulators, and more! nature.com/natcardiovascr…
X chromosome dosage compensation through the lens of human genetics! Females have two X chromosomes, but males have one. To compensate for this, one X is randomly inactivated in female cells. Some genes escape from this inactivation. Because both males and females are…
Great job!
📣New paper alert from the lab! Lab alumni Isabel, @n_toothacre, @claudia_lovell from @CAMBUpenn together with @PennEpiInst faculty @ericjoycelab @creminsLab investigate 3D ultrastructure of the inactive X in B cells. cell.com/cell-reports/f…
Woke or biology? There are actually more than the basic “male” XY & “female” XX sexes. Why? Because biology also creates people with single X chromosomes, or extra chromosomes like XXX, XXY, XYY, or XXX+, plus many 🧬genes. 👉All I’m asking is— please be kind to others. Thanks🙏
Nice paper showing ~1/540 people have a sex chromosome trisomy from 3 large biobanks (UKB, FinnGen, MVP) comprising 1.5 million individuals along with their phenotypic impact. medrxiv.org/content/10.110…
Using modern biological tools, researchers engineered #cancer cells with and without specific chromosome abnormalities, showing how tumors rely on them for survival and clarifying the biological role of aneuploidy. Learn more on #WorldCancerDay: scim.ag/4hlUseP
🚨Our study uncovering the functions of Y-chromosome genes in male fertility is now out in @ScienceMagazine 🔬🧬 science.org/doi/full/10.11…
StrPhaser constructs tandem repeat alleles from VCF data doi.org/10.1101/2025.0… NAVIP: Unraveling the Influence of Neighboring Small Sequence Variants on Functional Impact Prediction doi.org/10.1101/596718
We made the cover of Genome Research! Check out our latest paper on DDX3X and DDX3Y - the first X-Y gene pair with cross regulatory capabilities (genome.cshlp.org/content/35/1/2…).
Building on the great work of @ttukiainen, we find two additional completely skewed females in @GTExPortal. Using this unique genetic data we generate "A whole-organism landscape of X-inactivation in humans"! doi.org/10.7554/eLife.… @eLife. Great detective work by @BGylemo 🥳🙏
Autosomal random monoallelic expression drives incomplete penetrance of inborn errors of immunity, highlighting the importance of considering both genotype and the ‘transcriptotype’ in monogenic disorders nature.com/articles/s4158… @123456789Dusan @Nature @stewart_ojay
Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis. New study by Yong Du, Bérénice Faz-Lopez, Jean-Charles Guéry (@CharlesGuery) @Univ_Toulouse, Franck Barrat @HSpecialSurgery and colleagues: hubs.ly/Q02_C96b0 #Autoimmunity
Congrats!! 🥳🥳🥳
We've been awarded a UKRI MRC grant to examine the causes and consequences of #heterochromatin hypomethylation in cancer 🥳. #postdoc opportunity coming in the near future. #epigenetics. Please share with anyone who might be interested.