Francesco Scavone
@scafrancesco1
Biology @Stanford | Kopito lab | ubiquitin & UBLs, ribosome, protein quality control | Foodbank volunteer | @fscavone.bsky.social | 📷: Sicilian landscape
Check out our recent work @Nature revealing new insights into the structure(s) of the UFM1 E3 ligase complex bound to 60S ribosome and mechanism of 60S release from the translocon! nature.com/articles/s4158…
Fresh out of the oven, our collaboration with the Kopito Lab - UFL1(E3) modifies, binds to, and dissociates the 60S subunit from the Sec61 translocon! #ribosome #cryoEM
New online! UFMylation-dependent quality control of ER-stalled ribosomes bit.ly/4dW7b6U
Autophagy Receptors Couple Cargo Destined to Be Degraded with the Core Autophagy Machinery: link.springer.com/chapter/10.100…
Cool research projects for incoming postdocs!
And here goes our brand new flyer #postdocjobs. Please RT!
Preprint from our collaboration with the labs of Gerry Wright and Shura Mankin @shuramankin identifying the first translation inhibitor binding to the E-site of the bacterial ribosome… researchsquare.com/article/rs-692…
New paper out in Mol Cell, where we show how N-myristolytransferases lipidate proteins on the translating ribosome! Continuing our successful collaboration with @DeuerlingLab & Shu-ou Shan @Caltech @snsf_ch @ETH_en cell.com/molecular-cell…
Excited to share my first post-doc paper! Here, we make headway in understanding how metazoans regulate the pH of their organelles. Turns out, there exists a heterotrimeric complex required for V-ATPase assembly. We delve into the mechanism of this chaperone. Stay tuned for more!
New online! A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients bit.ly/3GjrXRN
🆕 Review by @J_ATPase on one of my favourite organelles: #vacuole (signaling & biogenesis & quality control) sciencedirect.com/science/articl…
With this new funding, we’re hiring PhDs and #postdocjobs Our #ERCAdG studies on the role of #RQC #ribosome #ubiquitin in #neurodegeneration will include using iPSCs, i-neurons, mammalian TC. The lab also has ongoing projects on #mitochondria and bacterial RQC.
Thrilled and honored to receive the #ERCAdG! This will fund us for the next 5 yrs for groundbreaking research My project SuTra focuses on the Surveillance of Translation, from sensing #ribosome stalling to #RQC. We aim to learn how defective surveillance causes neurodegeneration
Kar3 isn't just for mitosis—it helps take out the cellular trash. 🧹 New from Eric Rubenstein (@BallState): Kar3 & Vik1 are essential for ER-associated degradation, linking microtubules to protein quality control. 📖 molbiolcell.org/doi/10.1091/mb… #ASCB #CellBio #ERAD #Microtubules
Extracellular HSP90-Facilitated Degradation of Extracellular and Membrane Proteins by Bifunctional Small Molecules | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…
We are happy to share a new publication from the lab, in which we uncovered a new mechanism for influenza A virus (IAV) uncoating and host cell cytoplasm entry. science.org/doi/10.1126/sc…
Lysosomes are the cell’s recycling centers, but what pathways control the release of what they’ve broken down? In our new study, we uncover a surprising role for a scaffold associated with transport, JIP4, in controlling lysosomal cystine export 🧵 biorxiv.org/content/10.110…
Happy to present our latest paper with @pottslab & @Amgen in @J_A_C_S by co-first authors @C_M_Zammit & Cory Nadel on the discovery of a direct-acting covalent destabilizing degrader of AR and the undruggable truncation variant of AR, AR-V7, in androgen-independent prostate…
Happy to see our highlight out in @CurrentBiology discussing new findings related to NADH and FSP1 compartmentalization in ferroptosis. Lead by two terrific postdocs @AMegarioti and Kirandeep Deol! 🤩 cell.com/current-biolog…
🚀 Our latest publication is out! I am grateful to @DiMiccoLab for giving me the opportunity to work on this challenging project, where I literally put 100% of myself. Huge thanks to all our coauthors. 👉 Read more here: lnkd.in/dPRqyN4f 🧬The best is yet to come!!
Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by @AMegarioti & Sitao Zhang. A terrific collaboration with Da Jia. Brief Tweetorial! 1/9 pnas.org/doi/10.1073/pn…
TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains nature.com/articles/s4159…
Excited to present first publication from the Joshi lab, now in @JCellBiol. Here, we show that phosphatidic acid regulates Pex30 distribution at ER subdomains for lipid droplet biogenesis by binding to dysferlin domain. rupress.org/jcb/article/22…
Dan, a friend for many of us, passed at the end of last year. Before leaving, with his students and colleagues, he prepared this gift. Amazing. N-glycan-dependent protein maturation and quality control in the ER | Nature Reviews Molecular Cell Biology nature.com/articles/s4158…
Online today in @Nature - our latest study led by superstar postdoc @GillesRademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s4158… full text available here 👉 rdcu.be/em0VG and thread 👇