Marco Trujillo

💚My New Cover for @thewoolab @Harvard 💙 This art illustrates the discovery that #cereblon, a key protein in the cell’s waste disposal system, recognizes small chemical tags called #cyclic_imides (shown here in green at the tips of proteins). These naturally form at the end of…

Finally published. A big thank you to all contributors: Barley resistance and susceptibility to fungal cell entry involve the interplay of ROP signaling with phosphatidylinositol‐monophosphates - Weiß - 2025 - The Plant Journal - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/tp…

Undruggable ‘disordered’ proteins become druggable with new AI techniques from David Baker. @ScienceMagazine science.org/doi/10.1126/sc…

RNF114 is an E3 ligase that can recognize ADP-ribose and ubiquitin with separate domains. A proteomics approach is developed using these domains to map ADP-ribosyl-ubiquitylation sites nature.com/articles/s4158…

Are mini proteins the new antibodies? Mini proteins are highly stable, easy to manufacture, and very quick to design thanks to recent AI methods. Unlike mAbs, there is a large body of structural data to train machine learning models on to generate de novo mini protein binders.…

SIZ1 SUMOylates and stabilizes WRI1 to safeguard seed filling and fatty acid biosynthesis under high-temperature stress (Ruihua Huang , Mengrui Wen , Bojin Feng , et al) doi.org/10.1093/plcell… @ASPB #PlantSci

Chocolate consumption enhances cognitive function. There is powerful correlation between chocolate intake & the number of Nobel Prize recipients.

Online now! Site-resolved assessment of targeted protein degradation dlvr.it/TLn8Bk #chembiol

Happy to share our latest work on the specific role of phosphatase PLL2 in phytocytokine as opposed to MAMP signaling nature.com/articles/s4147… Big congrats to 1st author Rong Li !

New research in Science greatly expands the potential target scope of molecular glues and should stimulate the development of new small molecules that can selectively target therapeutically relevant proteins for degradation. Learn more in this week's issue:…

How do cells clean up misfolded proteins when they divide? This study finds that the cleanup crew includes the ER chaperone BiP and the proteasome, and kicks in right as cells finish dividing. Surprisingly, one major cell cycle regulator isn’t involved. elifesciences.org/articles/96675…

How plants sense injury in their barrier tissue, periderm? Painstakingly detailed and amazing work by post doc Hiroyuki Iida shows that wounding is sensed by the diffusion of two gases: ethylene and oxygen. nature.com/articles/s4158…

Great work by Li et al. (2025) on identifying the regulatory loop between #PlantTOR complex (TORC) via its RAPTOR1B subunit and the CBL4/CBL10–CIPK24 module in #Arabidopsis, which regulates the balance between plant growth and #SaltStress response 🧂🌱. 🔗doi.org/10.1093/plcell…

🆕 Review by @J_ATPase on one of my favourite organelles: #vacuole (signaling & biogenesis & quality control) sciencedirect.com/science/articl…

Check out our lab's newest pub, live in ACS ChemBio! We report interesting CRBN-independent activities of N-alkylated lenalidomide derivatives, or "capped imides." Congrats to Farah and all of the authors! 🥳💐 pubs.acs.org/doi/10.1021/ac…

Repurposing salicylic acid as a versatile inducer of proximity #PPStasis #CemicallyInducedProximity #Phytohormone #NPR1 nature.com/articles/s4158…

🔬📊 Comment: A checklist for designing and improving the visualization of scientific data @NatureCellBio nature.com/articles/s4155…

Delighted to share that our cryo-EM work with @inmunova on engineered immunogens capable of eliciting neutralizing antibodies against hemolytic uremic syndrome is featured on the cover of Protein Science! 🔗 doi.org/10.1002/pro.70…

Enjoying the first -real- summer day and bidding Aida farewell!

ROS in root nuclei can trigger redox-dependent multimerization of the auxin repressor protein IAA3 and modulate Auxin responses #PPstasis #Auxin #plantscience Kudos @sadanandomlab and Team! science.org/doi/10.1126/sc…