Layla Nassar
@LaylaNassar_
PhD candidate @YaleCellBio
We found that human cells lacking JIP4 accumulate massive lysosomes that become filled with cystine, a disulfide form of the amino acid cysteine. This mirrors what happens when cystinosin (CTNS, the lysosomal cystine exporter) is knocked out
JIP4 deficiency causes a novel lysosome storage disease arising from impaired cystine efflux biorxiv.org/content/10.110… #biorxiv_cellbio
I have an exciting research technician position in my lab @WUSM_BMB starting this August! Please spread the word. Apply here: bit.ly/4dsbTbZ. For more information, visit sites.wustl.edu/ghanbarpour/
Glad to report our study on the "dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis" is out in @MolecularCell. x.com/MolecularCell/…
We first identified that human A39 contains a unique loop 1 with 4 matrix Cys. Through protein-mRNA correlation and CHX chase, we reasoned that A39 is dual regulated by two mechanisms, fast degradation (independent of Cys) and metabolite sensing (dependent on Cys). (2/n)
This feels like an early Christmas present. An incredibly robust picture and reference set for subcellular localization. My favorite proteins all make sense and there is so much to discover. Explore with the companion website and uncover new biology: organelles.czbiohub.org
So stoked to be sharing this! New proteomics map of human subcellular architecture. CRISPR + organelle IP mass spec at scale. Check out pre-print biorxiv.org/content/10.110… and organelles.czbiohub.org. 🙌 to fantastic team @czbiohub SF & collabs! 1/2
VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1 biorxiv.org/cgi/content/sh… #biorxiv_cellbio
"When I first came here, I'm a bit ashamed to admit this, but I was trying to hide the fact that I came from Lebanon." 2021 medicine laureate Ardem Patapoutian, @ardemp, on the importance of inclusion and learning to love his immigrant background. #NobelPrize #MigrantsDay
Mutations in LRRK2 are likely causative of Parkinson's Disease but LRRK2's function remains elusive. Exciting new work from @XinboWang8 from @PDClab show a remarkable membrane remodeling activity! pnas.org/doi/10.1073/pn…
⚡️FLASH-PAINT 💡- rapid, highly efficient multiplexing (super-resolution) microscopy - is out on bioRxiv. (biorxiv.org/content/10.110…) We hope our 12-color super-resolution images electrify you as much as us: cellular complexity unlocked! @FSchueder @YaleCellBio #DNAPAINT🧬🔬
Lab super heros and villains for #Halloween2022 in @LuskingL @TJ_MeliaLab and @Shawn__Ferguson labs!
The faculty in @YaleCellBio and @YaleSCC strongly support our colleague Haifan Lin and his entire research group in the wake of his administrative suspension by @Yale, a step taken without any formal charges or due process. See our statement 👇👇