Michael Poeschla

From a broader perspective, our work shows how human genetic variation can reveal recent evolutionary adaptations, even at well-studied and conserved 🧬 loci, such as the HOXA cluster... Please check it out and feedback is very welcome. 🙏🙏 (fin)

1/14 On behalf of the amazing team in @JswLab, we’re excited to share PEtracer (biorxiv.org/content/10.110…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse…

Check out this fantastic plenary paper from @KaiTanLab1 and colleagues in @BloodJournal: tinyurl.com/mr9nzj3k @michaelpoeschla and I had the privilege to write a commentary, "Getting to the root of high-risk leukemias" tinyurl.com/htf3e8d2

Beautiful work demonstrating how common variants modify the penetrance of rare variants in both children and adults with telomere biology disorders (TBDs). According to the liability threshold model, rare and common variants additively raise disease risk beyond a threshold,…

Here we go again. Another company is selling embryo selection for intelligence. This time they claim to exclude the educational attainment predictor because of confounding. But the most recent data shows the intelligence predictor (which they use) is even more confounded!

Delighted to share my PhD thesis work is now published in @Nature! This study tracks the journey of blood stem cells in aging mice, examining how the clonal dynamics of blood production change over time. A short 🧵1/n #aging #stemcells #clonalhematopoiesis nature.com/articles/s4158…

Excited that my first 1st authored paper from my PhD research has been published in Anesthesiology! We found that neural oscillations in the alpha band of frequencies (8-12 Hz) during anesthesia can predict the risk of postop mortality up to a year after surgery. 🧵 (1/3)

1 / Interested in how genetic variants influence complex traits? In our new preprint, we show that variant effects depend on the polygenic background in which they occur, and why it is critical to consider polygenic background when studying complex traits. biorxiv.org/content/10.110…

Stem cell-like states confer poor outcomes in blood cancer—but what mechanisms drive this and how can they be therapeutically targeted? In our new preprint, we show how a single TF represses one enhancer to maintain a subset of high-risk leukemias: 🧵👇 biorxiv.org/content/10.110…

illuminating + surprising insights into polygenic disease risk in populations

Had a blast presenting our work yesterday at #ASH24! Feeling especially grateful for my mentors, colleagues and great friends who made this possible. A big thank you to @bloodgenes @RichardVoit @therealDrGundry @LWahlster and @mateusz_ant for their guidance and support.

What a fantastic talk by @tjflemin at #ASH2024 befitting of his selection as the top graduate student abstract award. Really proud of you for the culmination of this impactful project describing how MECOM drives AML and providing clues about how we can target it.

So excited to see our @NatRevClinOncol review come together! Thrilled to share insights on T cell dynamics in neoadjuvant ICI-treated HNSCC patients. Huge thanks to @DrUppaluri for your incredible mentorship and for all you’re doing to change the field!

My group's work dissecting the contribution of common variants to rare neurodevelopmental conditions is now out at nature.com/articles/s4158…. See this thread from co-first authors @qinqin_huang and @EmilieWigdor with a summary of the key findings.

Gene therapy is transforming how we treat genetic disorders, but what if mutations in more than 30 genes can cause similar symptoms? Now published in @CellStemCell (cell.com/cell-stem-cell…), we report the development of a universal gene therapy for Diamond Blackfan anemia. 1/n

1/9 As part of my Ph.D. @UTSWMedCenter in @MishraLab, I’m excited to share our Science Advances findings on how mtDNA mutations impact melanoma metastasis. science.org/doi/10.1126/sc…

Phenotypic variability in rare monogenic cases of telomere biology disorder with same genetic variant can be due to contribution of polygenic variation. Elegant study led by @bloodgenes @michaelpoeschla in collaboration with @SharonSavageMD and Us. medrxiv.org/content/10.110…

With controversy regarding the pseudoautosomal boundary, @AJHGNews latest article's analyses of the available data consistently validate the original position, narrowing the location of the boundary to a 201-bp window: cell.com/ajhg/fulltext/… @PageLabXY #ASHG #HumanGenetics

Stem cell gene therapy can be used to treat diverse genetic diseases. How does a person's disease background affect gene-edited stem cell activity? A pleasure writing this @NatureNV piece with @bloodgenes summarizing a fantastic study by Calabria & co nature.com/articles/d4158…