Madison Chapel
@ChapelMadison
MSc student in bioinformatics at UBC. My blood is at least 70% bubble tea.
0/ Essential reading for anyone training or using sequence-function models trained on genomic sequences! 🚨 In our new preprint, we explore the ways homology within genomes can cause leakage when training sequence-based models and ways to prevent it
Hard to believe it’s almost 2 decades since I was served, and later consumed, this molecularly precise model of a gram negative bacterium. The model captures 3 features of the cell: - high protein density, but low molecule number - carbohydrate surface - cheese in periplasm
🌯 BIOLOGY IS A BURRITO 🌯 Cells are crowded and very fast places. It's a miracle that anything works at all. The central dogma is often depicted as DNA -> RNA -> proteins, but it's so much more: A biophysical marvel inside the smallest of vessels. 💓 open.substack.com/pub/cell/p/bur…
Is curating, validating and transforming microbial contextual data bringing you down? Give the DataHarmonizer a try. You can make your own template about anything you want! We used it for harmonizing Canadian SARS-CoV-2 surveillance data. To find out more: microbiologyresearch.org/content/journa…
The building I work in has been leaving puzzles out for researchers to work on during downtime. I just stayed late to put the last few pieces of one together and I feel so mischievous. People will come to work tomorrow and be like "Wow who finished the puzzle" It was meeee 🕵️♀️
P-value now refers to the amount of Parafilm used in an experiment. Pass it on.
Sign up for Nature Briefing for a chance to win a Nature-branded toy to celebrate the Year of the Tiger: go.nature.com/3JY6ni5