Minhui Chen
@chen_cmh
Assistant Professor in Statistical Population Genetics @VCU_VIPBG | Former Postdoc at @UChicagoMed @usc_cge.
Happy to share that our work from the @nmancuso_ lab is out in @NatureGenet! We developed SuShiE, a multiancestry fine-mapping method for molecular traits. doi.org/10.1038/s41588…
Eleanor is the best—she’s the kind of person who can tackle any challenge that comes her way. Any lab would be lucky to have her!
I will present my poster Wed afternoon about single cell eQTL mapping using scalable count models. I m also looking for post doc lab. Happy to chat! 😊
Our work led by @liliw_wang on identifying trans genetic effects of gene networks is out in @CellGenomics today!
Trans-eQTL mapping in gene sets identifies network effects of genetic variants dlvr.it/T4w67y
Very happy to share our new paper now on @medrxivpreprint: “Genetic risk effects act in sets”, a great effort led my PhD student @JolienRietkerk, and performed together with collaborators @andywdahl, @AndrewSchork, @jonathan_flint1 etc. Thread 1/n
The fifth paper from the group this year. Led by a former postdoc @imyingchulo, our evaluation of polygenic scores (PGS) for BMI and T2D for Native Hawaiians is published in @CommsBio! nature.com/articles/s4200…
Check out our scPrediXcan paper cell.com/cell-genomics/… Led by talented @Charles_Zhou12, supervised by @MengjieChen6 and me, with thanks to many contributors scPrediXcan integrates deep learning and single cell expression data into a powerful cell type specific TWAS framework.
Work with @jnovembre on extending FEEMS to represent long-range gene flow on a background migration surface! The software for the method, called FEEMSmix, is readily available at github.com/VivaswatS/feems #popgen #Genetics #evolution
Jointly representing long-range genetic similarity and spatially heterogeneous isolation-by-distance biorxiv.org/content/10.110… #biorxiv_evobio
Family members share quite a lot genetically and environmentally. Curious about how we quantify the resemblance using any possible genealogy-traceable relatives to study human phenotypes?Join us at Exhibit hall Board 4118w to explore our latest work! 😀 #ASHG24
Excited to be heading to #ASHG24 today! I’ll be presenting at Wednesday’s poster session (Board 3016W) about our latest work on spatial sampling strategies & deleterious variants - come say hi!
I am very excited to share my study, trans-regulation of proteome through protein-protein interactions, at #ASHG2024 ! Please check my poster number 6077 on Wednesday (11/6) afternoon!
Our work on trans regulation of proteome and how protein-protein interactions play a role in it🧬.
🚨New Preprint Alert: Our work led by @JinghuiLi14637 is up on bioRxiv. We re-analyzed large maps of trans-pQTLs, and found that protein–protein interactions shape trans-regulatory impact of genetic variation on protein expression and complex traits. A brief thread🧵👇
Excited to share our work on alternative splicing (AS) rdcu.be/dSHtu. This version, compared to the biorXiv one, is much more succinct due to word limits; I hope you will have a look. Congrats to @BenjaminFair3 and @cfbuenabad for their incredible work!🧵⬇️
My lab continues to explore questions on AS, unproductive splicing, and co/post-txnal gene regulation. I would love to hear from you if you might be interested in joining us — we are a small but well funded group for experimental and computational work. thelilab.com /n
Please RT!
🧬Postdoc Opportunity in Statistical/Computational Genetics!🧬 Join our team in Human Genetics @PittPubHealth! Focus: Genetic etiology of cardiometabolic disease in Samoans & Pacific Islanders. Collaboration with @CharlestonCWKC tinyurl.com/pitthugen #Postdoc #Academicjobs
Excited to share the last paper from my PhD, advised by @spence_jeffrey_ and @jkpritch! We explore a new way to study selection on complex traits that circumvents some of the most troublesome limitations of GWAS biorxiv.org/content/10.110… (1/9)
New work about the Finnish pedigree and autoimmune diseases from @feiyi_wang, co-supervised by me, @andganna, and @TinskuT! Preprint: medrxiv.org/content/10.110…
T1D and other autoimmune diseases (AIDs) co-occur in families. How parental AIDs impact T1D risk in offspring and how much of the familial risk is explained by HLA and non-HLA variants? 👩🏻🦱🧔🏻♂️👶🏻 Find out more from this thread 🧵 and our new preprint ⬇️!medrxiv.org/content/10.110…
So proud that this work is now published @AJHGNews. It was truly an effort of a team of undergrad students (at the time), led by @itscahoon. It was also a project used to introduce new grad students or others just getting into genomic analysis - the team effort really worked out!
📢New from @itscahoon @CharlestonCWKC & co 📰Imputation accuracy across global human populations cell.com/ajhg/abstract/…
Our new work uses GxDrug interaction to model genetic effects on drug response in cross sectional data. Includes a new method for GxE TWAS. There are important caveats, but we hope this is a step toward more precise treatments
New preprint. In this paper we quantify heritability of drug response and identify involved genes by applying gene-environment interaction methods to biobank data. medrxiv.org/cgi/content/sh… 1/4
Very nice to see this work out w/ some of my closest colleagues! To reach broader audience and improve accessibility, not only is @GenomeBiolEvol open access, we also translated the abstract to Chinese, Portuguese, and Spanish! Here's the Chinese version (I had lots of help!!)
Our perspective piece "The Promise of Inferring the Past Using the Ancestral Recombination Graph (ARG)" is out. Work with @deboraycb, @christiandhuber and @CharlestonCWKC : academic.oup.com/gbe/article/16…
1/5 Our work on the relationship between diseases and childlessness is finally out in @NatureHumBehav! The paper: nature.com/articles/s4156… Our interactive dashboard: dsgelrs.shinyapps.io/DiseaseSpecifi…