Pankaj kapahi

We show a novel role for glycogen in neurons in protection against dementia. Glycogen accumulation is seen in fly, iPSC and human post mortem samples of Alzheimer’s disease. Breaking down glycogen rescues tauopathy by reducing ROS by enhancing PPP. nature.com/articles/s4225…

Next-generation phenotyping of inherited retinal diseases: Eye2Gene (AI-driven algorithm). Better-than-expert accuracy for 63 common genetic causes. @ucl @npontikos @GeoMichalis @MaximilianPfau3 @sktywagner @riksag @KonBalaskas #NIH @NatMachIntell: brnw.ch/21wUfkJ

Use of SRS to see vitellogenin accumulation during aging. However, our lab identified transcriptional reduction of vitellogenins as a mechanism for the longevity associated with calorie restriction (eat-2) in C. elegans in 2016. Please cite appropriately! biorxiv.org/content/10.110…

AGE Fellow Spotlight: Dr. Andrzej Bartke A pioneer in aging biology, Dr. Bartke was first to show that a single gene mutation affecting GH can extend mammalian lifespan. 📌 750+ papers 📌 45 yrs NIH funding 📌 Past President: AGE, ASA, SSR #AGEFellow #LongevityScience

We implemented a no-screens policy during the weekly lab meeting. Phones+laptops are banned. It's early days but (1) there was no palace revolt against the rules and (2) interactivity is up 20x with vivacious, passionate discussions of methods/results like never happened before.

📢#CallforPapers: Aging (Aging-US) invites #submissions on cellular #senescence - its mechanisms, functions & clinical applications - in memory of Dr. Judith Campisi. @marc_dema 📅Deadline: January 15, 2026 🔗Submission Details: aging-us.com/judith-campisi… #AgingResearch #oa

Some students can be ridiculously hypersecretive about their research (like concealing gene lists that are anyway in the public domain). Over time, they realize that not only nobody will steal their ideas, but that they'll be lucky if anybody is interested in them.

Yes. Writing is not a second thing that happens after thinking. The act of writing is an act of thinking. Writing *is* thinking. Students, academics, and anyone else who outsources their writing to LLMs will find their screens full of words and their minds emptied of thought.

Neuroscientist @magdalenasolyga shares how eLife helped her avoid reviewer overreach, accelerate publication, and reach the right audience, without compromising on rigour. Hear from authors like her: elifesciences.org/inside-elife/0…

🔥🔥🔥Read now our latest article on emerging concepts of the intricate interactions between the body and the germline influencing aging and genetic inheritance. The Somatic Impact on Inheritance and the Germline Control of the Soma | Annual Reviews - go.shr.lc/4m0k5n8

NIH will only accept six applications per PI per calendar year. drugmonkey.wordpress.com/2025/07/17/nih… via @drugmonkeyblog

Anybody in the Geroscience community want to be a journal editor? Nature Aging is hiring! springernature.wd3.myworkdayjobs.com/SpringerNature…

A tiny worm called C. elegans is a favorite among biologists. Studies of these wiggly worms have given surprising insights into human health and led to four Nobel Prizes. Learn more: bit.ly/4f05mXi

"Follow your enthusiasm!" Listen in on some career advice from chemistry laureate Benjamin List where he encourages us all to think outside the box. #CareerAdvice #NobelPrize

Childhood physical activity associates with adult fitness & lower risks of disease. Cause or effect? In mice, early-life exercise enhances late life metabolism, cardio function, strength & reduces frailty in old age. The epigenome never forgets. nature.com/articles/s4146…

Anabolic growth is harmful in the long run. All of this muscle building hype which derives mostly from Peter Attia is counterproductive to long-term health.

A personal message from 2022 chemistry laureate Carolyn Bertozzi to all young researchers on why to aspire to a career in science: ”I would want to share with them how a life in science is incredibly rewarding. It is rewarding because it is creative." #NobelPrize

RESEARCH | N Ahrentløv, K Rewitz et al. (U Copenhagen) The gut hormone tachykinin (Tk) is found to be regulated by protein intake in flies and mice. In flies, Tk is shown to impact food choices, sleep and lifespan 🐭🪰 nature.com/articles/s4225…

Behind the scenes story of the fantastic postdoctoral fellow Sudipta Bar! He is currently on the job market and can’t recommend him strongly enough

#authorinterview Dr. Sudipta Bar postdoc with Prof. Pankaj Kapahi’s lab @kapahi_pankaj at the Buck Institute for Research on Aging @BuckInstitute talks about his work on "Breaking Down Storage Brain Sugar May Help Fight Neurodegeneration" biopatrika.com/academia/resea… via @biopatrika

Nice work in mice and humans demonstrating that apolipoprotein M may attenuate age-related macular degeneration. #NIHfunded @washumedicine @Certimlee @aptelab @WashUMedDOVS @NatureComms paper: brnw.ch/21wU2ZA