Michael F. Chiang, MD
@NEIDirector
This is the official Twitter account of Michael F. Chiang, MD, Director of the @NatEyeInstitute @NIH. Tweets, retweets & follows are not endorsements.
In Blade Runner, “seeking answers was all about looking at the eyes”. At @NatEyeInstitute, we totally agree. If you’re interested in #vision, #research, grant funding, #Ophthalmology, or #Optometry: follow this feed. (I’ll also post about #informatics and #DataScience.) (1/3)

Next-generation phenotyping of inherited retinal diseases: Eye2Gene (AI-driven algorithm). Better-than-expert accuracy for 63 common genetic causes. @ucl @npontikos @GeoMichalis @MaximilianPfau3 @sktywagner @riksag @KonBalaskas #NIH @NatMachIntell: brnw.ch/21wUfkJ

One giant step forward for single-cell RNA sequencing: SCassist, an AI-based workflow assistant. NatEyeInstitute @rcaspi @IRPatNIH #NIHfunded @BioinfoAdv paper: brnw.ch/21wUq7f The SCassist package + tutorials on @github: brnw.ch/21wUq7g

Far from being hardwired at the start, the brain’s visual system gets fine-tuned by what babies see. And the rewiring to build binocular vision far more extensive than we thought. @SurLabMIT @MIT @KTsimring @NatureComms paper: brnw.ch/21wUof7

Newborn vision is blurry, which helps tune brain cells for low-color and low spatial frequencies. As vision improves, other cells get tuned for fine detail & rich color. @MIT @MarinVogelsang @VogelsangLukas @PipaGordon @mitbrainandcog #NIH @CommsBio: brnw.ch/21wUmpw

Option in settings lacking OCT: AI-driven prediction of primary open-angle glaucoma from retinal nerve fiber layer thickness from optic disc photographs. @BascomPalmerEye @WashUDeptMed #AIOphthalmology #NIHfunded @JAMAOphth paper: brnw.ch/21wUkCV

On the 10th anniversary of the @NIH BRAIN Initiative: Insights on culture change brought by multidisciplinary, team-science approaches and a new landscape of discovery in systems and computational neuroscience. @NINDSdirector @eLife preprint: brnw.ch/21wUiDM

Meet the ‘hemifusome’: A newly discovered vesicular organelle complex with a unique membrane topology. Could it play a role in protein and lipid sorting, recycling, and intraluminal vesicle formation? @IRPatNIH @BecharaKachar @NatureComms paper: brnw.ch/21wUdrP

Funding opportunity: Support for Research Excellence – First Independent Research Award 2025 applications due: 9/29/25 @NIHFunding @NIH Details: brnw.ch/21wUbON

Funding opportunity: Exploratory and early-stage projects focusing on undruggable target classes. @NIHFunding @NIH @ncats_nih_gov 2025 applications due: 10/17 Details: brnw.ch/21wUa7G

An #NIH Blueprint MedTech funding opportunity: advance medical devices to prevent, monitor, diagnose and treat disorders within the @NIH mission. 2025 applications due 9/29/25 @NIHFunding @NIH @NIH_NINDS Details: brnw.ch/21wU7VL brnw.ch/21wU7VK

Award opportunities via the @NIH_CommonFund 1/3 NIH Director’s Pioneer Award, applications due 9/9/25 Details: brnw.ch/21wU4Rt brnw.ch/21wU4Rs

2/3 NIH Director’s New Innovator Award, applications due 8/19/25 Supports early-stage investigators who propose bold and highly innovative research ideas with the potential for broad impact. Details: brnw.ch/21wU4Rq brnw.ch/21wU4Rp

3/3 NIH Director’s Transformative Research Award, applications due 9/3/25 Supports individuals or teams proposing remarkably innovative projects with the potential to create or overturn fundamental paradigms. Details: brnw.ch/21wU4Rl brnw.ch/21wU4Rm

Nice work in mice and humans demonstrating that apolipoprotein M may attenuate age-related macular degeneration. #NIHfunded @washumedicine @Certimlee @aptelab @WashUMedDOVS @NatureComms paper: brnw.ch/21wU2ZA

The new Disney Pixar movie Elio has the main character sporting an eye patch. This seems like a good time to spread the word about amblyopia, the treatment for it, and #NIHfunded research on brain-based causes of vision loss. brnw.ch/21wU0DC
Based on 2500 people from the Health, Aging and Body Composition study: Visual impairment and poor mobility independently predicted mortality risk. #NIHfunded @WakeForest @agingup @AmerGeriatrics paper: brnw.ch/21wTZbY

Interesting review on approved AI-based ophthalmic imaging devices in the UK, US, and Australia. AI tools must be held to the same evidence standards as tests or drugs. @Moorfields @ArielYHOng @EliotDow @pearsekeane @Denniston_Ophth @Nature article: brnw.ch/21wTXzX

Great piece on oculomics: Application of AI to deliver healthcare from the eye. @SallyLiuBaxter @n_weinreb @aaronylee @ShileyEye @UCSanDiego @NatEyeInstitute @JAMAOphth: brnw.ch/21wTUdG

From 5000+ participants in the @NIH @AllofUsResearch: U-shaped relationship between HDL and AMD risk, such that both high and low HDL are significantly associated with increased AMD risk. @jimmyschen @SallyLiuBaxter @EskoJeff @aao_ophth paper: brnw.ch/21wTSd7

A novel device (i-Onion) evaluates tear secretory response. Study shows tear reserve volume was preserved in glaucoma and cataract, despite decreased basal tear volume with age and disease @BascomPalmerEye The ECLA Journal: brnw.ch/21wTQcx
