Jon Marles-Wright
@jmarlesw
Structural/synthetic biologist, husband to @lis_lowe, father. Views expressed here are my own. He/Him
I was today years old when I learnt that 'wild-type' is an adjective and 'wild type' is a noun. For all my years as a scientist I have been throwing them around interchangeably.
The 3-decade-old competition that enabled the emergence and evaluate of AlphaFold has run out of NIH funding. The program will be terminated in weeks. This is terminating success. science.org/content/articl…
Latest BREX story from the lab - turns out there is a nuclease after all! Congrats to Jenny Readshaw and the whole team, including wonderful collabs Barry Stoddard, Brett Kaiser and @DarrenSmithdx. @NAR_Open @NEBiolabs @DurBiol academic.oup.com/nar/article/53…
Thanks to new funding from @wellcometrust we will soon be advertising two postdoc positions! Interested? Please get in touch in the first instance and I'll provide more info on the projects. You can also learn more on our lab website theradlab.co.uk
New tenure track assistant professor position in molecular microbiology in our department @DMF_UNIL @unil! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/applica…
We're delighted to announce that our conference "Protein Evolution, Design and Informatics Edinburgh 2026" will be running from the 13th-15th of May. Register interest here and please retweet! biochemistry.org/events-and-tra…
Very pleased to present the next pre-print from our lab #glycotime We showcase PNGaseL from Flavobacterium akiainvivens that we hope will be a useful tool for the glyco community 🍬🧪👩🔬 Special shout out to @CassieBakshani and Paulina (Ludger) biorxiv.org/content/10.110…
We love generating data! But what should we do with it? We collaborated with the @jlistgarten on ProteinGuide - a new method for using experimental data to guide protein generative models. Congrats to @junhaobearxiong, Hunter, @MariaLukarska, @Ishan__Gaur and @loltrogge! ⬇️⬇️
Guide your favorite protein generative model with experimental data? Meet ProteinGuide - a method to condition pre-trained models on properties without retraining. We validated it both in silico by guiding ProteinMPNN and ESM3 on 3 tasks and in vitro by engineering base editors.
Opportunities for microbiome-based therapeutics in preterm infants Led by Emily Wroot, alongside @mashedbanana @ChapJ95 and @neonatalbiobank. Hopefully this provides a timely insight for clinicians and researchers interested in preterm infants and beyond nature.com/articles/s4156…
Finally, we're recruiting! If you'd like to do a PhD using NMR structures to study the dynamics of a metalloenzyme, then you're in luck! Come to Warsaw for this project, in collaboration with Simone Ciofi-Baffoni's group at CERM, Florence: ibb.edu.pl/app/uploads/20…
Our #RNA multimer paper out now in @nature! #cryoEM of 2 distinct nanocages GOLLD and ROOL and membrane-associated OLE. Multimers at ultra-low concentrations, special covariance for cross-molecule kissing loops, and speculation on function nature.com/articles/s4158…. 1/2
Happy to share @c_elfmann‘s new paper! Discover easy tools to make the most out of AlphaFold and its iterations! @TrendsMicrobiol @uniGoettingen #subtiwiki Cutting-edge tools for structural biology: bringing AlphaFold to the p... sciencedirect.com/science/articl…
My dept in London at Imperial (Bioengineering) is recruiting a group leader at Professor level 🧑🎓 Please RT. It's a great department with world-class expertise in all sorts of biomedical & biological engineering topics, including synthetic biology. 🇬🇧imperial.ac.uk/jobs/search-jo…
New preprint out today: doi.org/10.1101/2025.0… In it we tackle making our favourite plant-growth promoting bacterium engineerable, with lots of useful genetic tools #synbio #syntheticbiology #engineeringbiology
Registration and abstract submission open for Designer Biology 2025 in Newcastle 29-31 July. Looking forward to a great meeting in the best city in the world: efbiotechnology.org/designerbiology
Seven Critical Challenges in Synthetic One-Carbon Assimilation and Their Potential Solutions—led by @FavoinoGiusi & @OscarPuiggene @LabNikel @FEMSmicro #Microbiology #Reviews #SynBio #Metabolic #Engineering academic.oup.com/femsre/advance…
New paper alert 🚨 We've solved the complete structure of a C. difficile-infecting phage using cryo-EM, in both extended and contracted conformations - published today in Life Science Alliance
High-fidelity in vitro packaging of diverse synthetic cargo into encapsulin protein cages "Fluorescent dyes, proteins and cytotoxic drug molecules can all be selectively packaged via a peptide-mediated targeting process." onlinelibrary.wiley.com/doi/10.1002/an…
I'm recruiting a PhD student! Details on the project and how to apply at this link: stockholmcazyme.com/2025/03/21/phd…
1/2 Here we unexpectedly find that protein S20/L26—identified at the dawn of ribosome research but then deemed a ribosome isolation artifact—is indeed a genuine component of the large ribosomal subunit. More on this ribosome content variation: nature.com/articles/s4146…
We're hiring!🚨Our lab @SydneyChemistry is looking for two new #chempostdoc for our drug discovery program: 1) Synthetic/Med Chem (small molecule hit-to-lead)🧪 usyd.wd3.myworkdayjobs.com/en-US/USYD_EXT… 2) Chemical Biology (peptide inhibitors)🦠 usyd.wd3.myworkdayjobs.com/en-US/USYD_EXT… Pls spread the word!🙏