Christopher W. Wood
@ChrisWellsWood
Senior Lecturer in Biotechnology, University of Edinburgh. We develop methods and tools to make protein design and engineering more reliable and accessible.
Our paper on the Protein Design Archive has just been published in @NatureBiotech! It describes our web application for exploring designed proteins (link ⬇️) and contains analysis of how they have changed over time. @MartaChronowska @mjstam @WoolfsonLab nature.com/articles/s4158…
The January update for the Protein Design Archive is now live! Take a look at @MartaChronowska's post to see some of the interesting designs that have been added this month.
🎇 We're kicking 2025 off with a Protein Design Archive update, adding structures such as miniaturized electron-transfer proteins, small molecule and protein binders, beta barrels and hairpins, oligomers, and more! Check out all of them at pragmaticproteindesign.bio.ed.ac.uk/pda/ @ChrisWellsWood
🎇 We're kicking 2025 off with a Protein Design Archive update, adding structures such as miniaturized electron-transfer proteins, small molecule and protein binders, beta barrels and hairpins, oligomers, and more! Check out all of them at pragmaticproteindesign.bio.ed.ac.uk/pda/ @ChrisWellsWood
Designing proteins from scratch opens exciting new possibilities for solving global challenges in health and sustainability. That is why we are funding an ambitious new Center for Protein Design at @koebenhavns_uni. Led by Professor Dek Woolfson, world-renowned in this field,…
That's the April update for the Protein Design Archive available and beyond the new structures, @MartaChronowska has added a feature that adds search parameters to the URL, so you can share your search e.g. all Bill DeGrado designs before 2010: pragmaticproteindesign.bio.ed.ac.uk/pda?deposition…
The Protein Design Archive (PDA): insights from 40 years of protein design go.nature.com/4iNRFLI
A new resource for protein design: the Protein Design Archive Protein designers have long aimed to explore the vast possibilities beyond nature’s existing structures, seeking to learn how amino acid sequences fold and function in ways that evolution never tested. Chronowska et…
There was a Nobel Prize awarded for protein structure prediction and design, but there's still no protein emoji. Come on @unicode, how is ginger 🫚 or a clamp 🗜️more important than the class biomolecule that does (more or less) all the biochemical work in every living thing!?👎
Another publication in collaboration with Tom Oliver's group in @BristolChem We harness de novo α-helical barrels as "molecular flasks" to bind and orient small molecules in aqueous solution. Using FRET and photodimerization, we showcase the potential for templating new chemistry
Confinement and Catalysis within De Novo Designed Peptide Barrels | Journal of the American Chemical Society @DekWBristol @BristolChem @BrisSynBio @MaxPlanckBris pubs.acs.org/doi/10.1021/ja…
All PDB ligands now available on AlphaFold3 server.
The AF3 server has now added a new entity type (in addition to protein, DNA, RNA, ions or a small # of ligands, like ATP), namely CCD Codes. Interesting. They must adhere to CCD version of 2924_10_28, with allowed A-Z, 0-9 characters. No other explanation
Delighted to announce that 'Engineered enzymes for enantioselective nucleophilic aromatic substitutions' is out now in Nature! Congratulations to Tom, George and everyone else involved in this project! 🎉🎉🎉 nature.com/articles/s4158…
#EngineeringBiology #SustainableManufacturing activities @EdinburghUni @Dr_StephenW bbc.co.uk/news/articles/…
Diego Oyarzun is next at #NGSB24 who is going deep into how we train AI models from biological datasets and revealing some fascinating limitations and ways around them. Really great talk.
I'm looking for candidates for an @EastbioDTP studentship in my lab. If you are enthusiastic about cellular circadian rhythms, have a look and get in touch! findaphd.com/phds/project/e…
🙌🧬 Incredibly proud of the Wells Wood lab's results in round 2 of the @adaptyvbio protein design competition! All of our designs expressed and one of them bound to EGFR.😀🎉 Check out the list below for the different models and software that we used to do this. 👇 (1/4)
PROTEIN DESIGN COMPETITION ROUND 2 The long awaited results are here -- and they don’t disappoint! 📈 We doubled the number of proteins we tested in our lab from 200 to 400! 🧬 Out of those 400 proteins, 378 expressed (95% expression rate!) 🚀 Out of those 378 expressed…
Congratulations @Dr_StephenW on your @ERC_Research 2024 Consolidator Grant! The €2M #ERCCoG grant for the MICROCHEMIST project will help to accelerate the transition towards the environmentally-friendly production of chemicals ➡️edin.ac/41cgbR9