Amar Deep
@iamamardeeep
Out today in @Nature! I am thrilled to share our work on the PARIS immune system in its final published form. Huge thanks to my mentor, Kevin Corbett @_KevinCorbett, and my teammates. See the thread below in comment section for a quick summary! nature.com/articles/s4158…
Muscle mass loss in people aged 65+ taking GLP-1 drugs acpjournals.org/doi/10.7326/AN… @AnnalsofIM Emphasis on resistance training (RET) and close monitoring recommended
Another very cool defense mechanism from @SternbergLab
Our latest story is now online @Nature! We discovered a phage defense system that deploys kilobase-long DNA homopolymers to protect against viral infection. Congratulations to all authors, and to the @WiedenheftLab for a fun and fruitful collaboration! nature.com/articles/s4158…
Happy to share that I've been selected for the Haryana Yuva Vigyan Ratna Award. I also share a heartfelt note. tribuneindia.com/news/haryana/s…
Feeling proud of @arya_subhash on his recent @NatureCellBio publication from @parentclab nature.com/articles/s4155… #proud #mentor @CSIR_IMTECH @CSIR_IND
In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by @US_FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,…
1/10 Today in @ScienceMagazine in collaboration with @liugroup we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-UbCR…
Thank you @India_Alliance for highlighting our work!! I truly couldn’t have set up the lab without the funding from IA- @DBTIndia @wellcometrust!! Thank you @IITKanpur @mfcem_iitk @BSBEIITK1 for the support!!
The fourth article of our #Diabetes series features Dr. @saip_pydi! He studies how G-protein signals in immune cells affect inflammation and metabolism in obesity and type 2 diabetes. Read more here: tinyurl.com/5n7n3zae
How to find fantastic new #RNAs? The J2 antibody is the gold standard to detect, map & enrich dsRNAs. Co-led by @CharlesBNader, Kevin Juma, Ankur Bothra & Steve Leppla’s lab, we visualize how J2 recognizes dsRNA and define its epitope, specificity & bias. doi.org/10.1101/2025.0….
White smoke, we have not only a new pope, but also 16 new anti-phage systems in integrons ! In collaboration with the @amazeld lab, we show in our new paper that cassettes of these large platforms encode known anti-phage defenses and uncovered 16 new ones. science.org/doi/10.1126/sc…
Now published @CurrentBiology. Happy to share latest work from the lab led by @ashamjos and @Adhikashreni1, describing replisome speed variation in Caulobacter! cell.com/current-biolog…
Great job, Manoj!
Very happy to share that our work on the discovery of new class of Ribosome targeting antibiotic is published in Nature today. A beautiful example of a multi collaborative study. Many thanks to all the people who contributed.
Please spread the word! We have an opening in the Atkinson lab for a post-doc with a focus on molecular mechanisms of microbial immune systems. Can be a fully computational or experimental or hybrid project. Read more & apply here: lu.varbi.com/en/what:job/jo… #phage #Bioinformatics
It was honour to meet Honourable Chief Minister, Shri Yogi Adityanath in Lucknow to discuss implementation of #Bedaquiline in state hospitals and its positive impact on TB patients and novel AI drug discovery programs for neglected diseases. Thanks @myogiadityanath for your…
It is finally out! Muntathar Al-Shimary, Doudna Lab, @bradyfcress and I present a gene knockdown tool that works in diverse phages: CRISPRi through antisense RNA Targeting (CRISPRi-ART)! Check out the final paper in @NatureMicrobiol nature.com/articles/s4156…
Claire's paper now entitled "Multi-interface licensing of protein import into a phage nucleus" is now published here: nature.com/articles/s4158… @CKokontis used classic genetics to figure out how proteins are selected for import into a "phage nucleus" Some notable additions:
New preprint from the lab, led by outstanding student Claire Kokontis! (@CKokontis) In this work Claire et al. discover Imp1-Imp6, phage proteins required for the selective import of proteins into the jumbo phage nucleus! Imp1 (below) is the special one. biorxiv.org/content/10.110…
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis…
Read more about our discovery in the thread by lead author @TanaWein 👇 x.com/TanaWein/statu…
Very happy our paper on CARD domains in gasdermin anti-phage defense systems is now published in @Nature 🥳 Thanks to all the people involved especially the Kranzusch lab and @SorekLab nature.com/articles/s4158…
Very happy our paper on CARD domains in gasdermin anti-phage defense systems is now published in @Nature 🥳 Thanks to all the people involved especially the Kranzusch lab and @SorekLab nature.com/articles/s4158…
Brilliant work from the immensely talented @Surbhi_Yadav_ with @arnabshau and @ChackoFeby describing a remarkable mechanism used to stall chromosome replication progression in nutrient-starved bacterial cells
The preprint of first manuscript from my PhD work at the Radhakrishnan Lab @sunishk is now on bioRxiv!🥳 We uncover new insights into the mechanism by which bacteria stop DNA replication when nutrients become limited.#Caulobacter @arnabshau @ChackoFeby biorxiv.org/content/10.110…
1/2 Elated to share our collaborative work with Monika Sharma @PlakshaUniv in @NAR_Open We used a combination of genetics, biochemical and simulation studies to probe allostery in E. coli DgoR, a GntR/FadR family transcriptional regulator. @DBS_IISERM doi.org/10.1093/nar/gk…