Chris Hsiung 熊
@hsiung_chris
Molecular biologist | Assistant Professor @UCSF | synthetic gene regulation, combinatorial genetics, tissue biology | #ClimateCrisis
My lab at UCSF (hsiunglab.org) is looking to recruit multiple postdocs across the spectrum of wet/dry lab interests to contribute to our research in synthetic gene regulation, combinatorial genetics, and tissue biology (including liver biology and immuno-oncology). We…
Our preprint describing the Range Extender element, which is required and sufficient for long-range enhancer activation at the Shh locus, is out in @Nature. nature.com/articles/s4158…
How do enhancers work over distances that sometimes exceed megabases? Excited to share our work led by @gracecbower where we uncover a unique sequence signature globally associated with long-range enhancer-promoter interactions in developing limb buds: biorxiv.org/content/10.110… 1/
Enhancers, how do they work (in vivo)? To find out, we mutagenized 7 human enhancers comprehensively in 12bp blocks and scored for activity in developing mouse embryos. rdcu.be/erD22 @Nature #mutagenesis #noncoding #enhancers
Nice blogpost on "PhD-level" AI agents which hits on a concern I've also felt: their current failure modes are the zero tolerance nightmare scenario for an academic researcher (inventing references, manufacturing data, "solving" bugs by removing functionality, etc).
@nbcnews has published a powerful feature on the death of pioneering Chinese American neuroscientist Dr. Jane Wu, who died by suicide on July 10, 2024, after Northwestern University abruptly shut down her laboratory: nbcnews.com/news/asian-ame…
I'm super excited to share that I will be joining the Department of Biology at @Stanford as an Assistant Professor in October 2025! I’ll also be a member of the Stanford Stem Cell Institute @CellStanford. Incredibly grateful to be starting my dream job!🧠🧬🖥️
Very excited to share our work on high-resolution single-cell Micro-C, which is on bioRxiv now. Here we reveal that cohesin-mediated loop extrusion participates in transcription with kilobase-resolution single-cell 3D structures. biorxiv.org/content/10.110…
New from the Rouhanifard Lab! What if we could sort single cells based on whether a specific gene was actively being transcribed—and then ask what drives that burst? Introducing: NuclampFISH
New pre-print(s) from the Sternberg Lab in collaboration with @LeifuChangLab! We uncover an unprecedented molecular mechanism of CRISPR-Cas12f-like proteins, which drive RNA-guided transcription independently of canonical promoter motifs. Full story here: tinyurl.com/mr3fd493
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!
Check out our latest preprint, led by @schen_sc, that brings together an amazing team of scientists from several labs to tackle a fundamental problem in biology: how do cells regulate expression of their tRNAs? biorxiv.org/content/10.110…
So excited to see this live! Awesome work from @giannatbusch on the concept of population-based synergy—using cell-to-cell heterogeneity to uncover new therapeutic vulnerabilities!
Excited to share our new work on the distinct drug sensitivity profiles of heterogeneous therapy-resistant melanoma cells! @arjunrajlab biorxiv.org/content/10.110… (1/10)
Long-range massively parallel reporter assay reveals rules of distal enhancer-promoter interactions biorxiv.org/content/10.110…
I'm excited to release what I've been cooking up the past few months at @arcinstitute BINSEQ is a family of binary file formats for sequencing data built with paired records and parallel processing in mind with big performance gains (2x-40x) over gzip-fastq with similar storage
BINSEQ: A Family of High-Performance Binary Formats for Nucleotide Sequences biorxiv.org/content/10.110… #biorxiv_bioinfo
Our new review on why some hearts heal and others don’t. Led on our gifted postdoc @Makoto3173.
"Why Some Hearts Heal and Others Don’t: The Phylogenetic Landscape of Cardiac Regenerative Capacity" is now published in Seminars in Cell & Developmental Biology. Let's explore the evolutionary perspective on cardiac regeneration 🫀👇 🔗 authors.elsevier.com/a/1kvpS3si8Q0a… @GuonHuang Lab
We've recruited one postdoc and are looking for more! We like both tech dev and fundamental biology and have so many ideas to share with you. Hybrid wet/dry biologists welcome! hsiunglab.org
My lab at UCSF (hsiunglab.org) is looking to recruit multiple postdocs across the spectrum of wet/dry lab interests to contribute to our research in synthetic gene regulation, combinatorial genetics, and tissue biology (including liver biology and immuno-oncology). We…
I am excited to share our new work from @CreminsLab heterochromatin in fragile X syndrome (FXS), the most common monogenic cause of autism spectrum disorder. We previously described ectopic H3K9me3 domains in FXS, BREACHes, though the clinical significance is unexplored. 1/n
1/10 Excited to share our latest - the first whole-body map of both DNA methylation and 3D genome at single-cell resolution.
Super excited to launch nimbusimage.com, our cloud-based image analysis platform! nimbusimage.com Docs here: docs.nimbusimage.com Free tier available!
Introducing RAEFISH, our lab's new flagship image-based spatial transcriptomics technology that simultaneously enables single-molecule spatial resolution and whole-genome level coverage of long and short, endogenous and engineered RNA species in cell cultures and intact tissues.
check out this amazing free software for flow analysis. say goodbye to flowjo.
A new version of Floreada.io is out! This version adds the ability to export FlowJo workspaces and ACS files. It adds features to make pipelines and gates more intuitive. Also, our FCS file editor can now remove and reorder parameters. Try it out now! #flowcytometry