Chenxu Zhu

We're incredibly excited to share our new method, Paired-Damage-seq, out @naturemethods today! This technique allows us to jointly analyze oxidative DNA damage and SSBs with RNA, all at the single-cell level (1/5). nature.com/articles/s4159…

Gene expression involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. We developed ChIP-DIP – a method for simultaneous, genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. biorxiv.org/content/10.110…

Our Single Cell Genomics Day - highlighting our favorite new sc/spatial methods - starts Friday at 10AM ET! The most common question we get: is this open to anyone? Yes! Talks are free and live-streamed (no registration required) on Youtube and satijalab.org/scgd

Interested in single cell genomics but need help getting started? Check out the full agenda for our Single Cell Genomics Day on Friday 4/25. All talks will be live-streamed (no registration required) at satijalab.org/scgd25

We are proud to announce Bing Ren, PhD, as the new Scientific Director & CEO of the NYGC. Dr. Ren brings his expertise in the fields of genomics & epigenetics to the NYGC & Columbia University, where he will hold a joint appointment. For more on Dr. Ren: bit.ly/3DJXtah

Also in this issue: our first #ToolsoftheTrade article by Dongsheng Bai (@bds1993) and Chenxu Zhu (@chenxuzhu) @nygenome on SIMPLE-seq to decode DNA methylation dynamics in single cells go.nature.com/3VWmju4 #NRGToT

Our first #ToolsoftheTrade article has just been published go.nature.com/3VWmju4 Dongsheng Bai (@bds1993) and Chenxu Zhu (@chenxuzhu) @nygenome wrote about SIMPLE-seq to decode DNA methylation dynamics in single cells (based on their @NatureBiotech paper with @YiChengqi)

Single Cell Genomics Day starts tomorrow at 10AM ET! Come for the awesome keynotes (@JD_Buenrostro , Xiaowei Zhuang, @IdoAmitLab) and to learn about our favorite new methods and trends for the field in the last year. All talks streamed on Youtube and satijalab.org/scgd

What if 1 million scRNA-seq libraries can be prepared within $1k? Here we go 👉 21 million cells from 623 mouse tissues, spanning 5 life stages & 3 genotypes, all in a SINGLE study by ONE remarkable student Zehao @Tommyz626 from our lab @RockefellerUniv! shorturl.at/epsz7

Programmable RNA base editing via targeted modifications | Nature Chemical Biology nature.com/articles/s4158…

SIMPLE-seq @NatureBiotech developed by Dr. Dongsheng Bai @bds1993 et al. that simultaneously detects 5mC and 5hmC at the single-cell and single-molecule level! Jointly published by Prof. Chenxu Zhu @chenxuzhu from Cornell University and us. nature.com/articles/s4158…

Thrilled to share our latest research, SIMPLE-seq, a high-throughput single cell method enabling simultaneous profiling of 5mC and 5hmC. Our SIMPLE-seq work is online now @NatureBiotech! Huge thanks to the exceptional mentor @YiChengqi @chenxuzhu, and all lab members!

Want to infer causal regulatory changes from scRNA-seq/spatial data? We combined Perturb-seq with @ParseBio + @UltimaGenomics to systematically perturb signaling regulators across six cell lines and learn their downstream targets. Preprint and data at biorxiv.org/cgi/content/sh…

Want to hear about the latest updates/new techniques in single cell and spatial genomics? Check out my lab's eighth annual Single Cell Genomics Day on March 29. Keynotes from @IdoAmitLab @JD_Buenrostro and Xiaowei Zhuang. Please RT/spread the word! satijalab.org/scgd

“The Information Theory of Aging” was published today. Free copy @NatureAging rdcu.be/dtGSC

Single-cell Genomics! Paid Internship! Cutting-Edge Research in NYC! Apply now :)