Chengqi Yi
@YiChengqi
Professor at Peking University. Yi lab is interested in RNA modifications, Epitranscriptomics and Genome Editing. Welcome to communicate with us!
We are pleased to introduce our new idea of RNA base editing, a safe RNA base editing tool. Excellent work by Dr. Jinghui Song @Jinghui_Song and Liting Dong! Click to view the full article ↓ authors.elsevier.com/a/1gFSa3vVUPK9…
So excited to share our work (cell.com/molecular-cell…). We developed a programmable RNA base editor, termed RESTART in the lab of Prof. Yi (@YiChengqi). Hoping our work will be a promising tool for therapeutics of PTC-disease. cell.com/molecular-cell…
AlphaFold2 and RoseTTAFold are limited to predicting the 3D structure of proteins. A new all-atom method models complete biomolecular assemblies, including proteins, nucleic acids, small molecules, metals, and covalent modifications. #NBThighlight science.org/doi/10.1126/sc…
A cool technology developed by my colleague Chengqi Yi at Peking University to correct premature termination codon mutations doi.org/10.1038/s41587…
Near-cognate tRNAs increase the efficiency and precision of pseudouridine-mediated readthrough of premature termination codons - @PKU1898 go.nature.com/3ToILdE
Thanks Julia. This is an awesome summary of current HYERs!
A ribozyme that cuts DNA - programmably!! It has a ways to go before it can be a precision genome editing tool - short target recognition sequence, doesn’t bind dsDNA well - but an exciting discovery nonetheless! Study from @GogoLiu lab at @Tsinghua_Uni, published in…
Honored that our RNA base editor "RESTART" has been selected as the best technology of Molecular Cell 2023. Huge thanks to my mentor Prof. Yi (@YiChengqi). …bestof2023.elsevierdigitaledition.com/main/119/index…
SIMPLE-seq @NatureBiotech developed by Dr. Dongsheng Bai @bds1993 et al. that simultaneously detects 5mC and 5hmC at the single-cell and single-molecule level! Jointly published by Prof. Chenxu Zhu @chenxuzhu from Cornell University and us. nature.com/articles/s4158…
#RESTART #RNAEditing We are delighted that RESTART has been recommended as one of the "Best of Cell Press" and published in @MolecularCell . This is a novel and elegant RNA editing tool developed by Dr. @Jinghui_Song et al. Link to our paper: sciencedirect.com/science/articl…
We have witnessed this moment!!!
The first approved CRISPR medicine in the world for sickle cell disease and beta thalassemia! A huge victory for biotechnology, patients, and humanity businesswire.com/news/home/2023…
The first approved CRISPR medicine in the world for sickle cell disease and beta thalassemia! A huge victory for biotechnology, patients, and humanity businesswire.com/news/home/2023…
🚨 New #NRMCBReview Alert! 🚨 "Regulation and functions of non-m6A mRNA modifications" by Hanxiao Sun, Kai Li, Cong Liu and @YiChengqi This Review discusses the emerging functional mechanisms and roles of various non-m6A mRNA modifications. 🔗go.nature.com/3pLzvUU
Congratulations to Chuan He, 2023 Wolf Prize laureate in Chemistry! @UChiChemistry @UChicago
Always double check your work. @HermanZhaoZzzz discusses extensive off-target editing in the nuclear genome induced by a mitochondrial base editor. @Nature @YiChengqi #JRNLclub jrnlclub.org/research-films…
Always double check your work. @HermanZhaoZzzz discusses extensive off-target editing in the nuclear genome induced by a mitochondrial base editor. @Nature @YiChengqi @PKU1898 #JRNLclub jrnlclub.org/research-films…
Congratulations to our "GLORI" team!
Absolute quantification of single-base m⁶A methylation in the mammalian transcriptome using GLORI - @PKU1898 go.nature.com/3zmJj9p
Absolute quantification of single-base m⁶A methylation in the mammalian transcriptome using GLORI - @PKU1898 go.nature.com/3zmJj9p
I’m super excited to start my new journey as @GRO_Broad Fellow @broadinstitute and a Junior Fellow of the Society of Fellows @Harvard. I will lead an independent group to study the principles and mechanisms of genome organization underlying development, disease, and evolution.
We are looking for postdoctoral fellows and welcome friends from all over the world to contact us. Our official website is yilab.org.cn