Charlie Bell
@charles_bell92
Post-doc in the Faulkner lab and Dawson lab alumni ARC DECRA Fellow Interested in how gene regulatory mechanisms contribute to biological complexity
Cofactors are a crucial part of the gene activation process. Yet, we still don't have a comprehensive understanding of how and why they are used by different genes. Proud to present our attempt to address this key question, now published nature.com/articles/s4158…
Great to see Vasan‘s stunning work on Pol II termination out. Pulling on nascent RNA leads to hypertranslocation and destabilization of the elongation complex.
Very pleased to share our work on the polyadenlyation-independent termination of Pol II by the helicase Sen1. nature.com/articles/s4159… Extremely grateful to the generous freedom and support of Patrick @mpgpresident for developing this work. A short 🧵 below.
Delighted to share our new approach to enhance CAR T cell function in solid tumours published today @Nature. In this work we identify a new strategy to generate armoured CAR T cells. nature.com/articles/s4158…
1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance? We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains. 🧵 biorxiv.org/content/10.110…
Site-saturation mutagenesis of 500 human protein domains: nature.com/articles/s4158…
A lot of folks in artificial intelligence (AI) & robotics seem to keep forgetting that what people do on a daily basis, like identifying, picking up & holding a cup of water is a very complicated process from a computational modeling perspective. Moravec's Paradox:
Some uncomfortable truths starting to set in. @ChombaBupe @TrueAIHound @DHuskytron @daaaaashr
Nature research paper: Machine-guided design of cell-type-targeting cis-regulatory elements go.nature.com/3A0nksF
Happy to share that the paper on enhancer interactions led by @zrcjessica and I from my time in the @GrahamMcVicker lab is now published in Cell Genomics! cell.com/cell-genomics/… A thread on some of the new analyses below: (1/n)
I’m excited to share the programme of my new series of lectures @cdf1530 in Nov-Dec. I will devote next 2yrs to information flow. As usual, I speak en Français, but all slides (pdf) in English, self-explanatory, video on Youtube. Stay tuned or visit if in Paris. It’s free
You mean mass redundancies, the evisceration of entire disciplines, rampant managerialism, and the fanatic embrace of a profit-driven model of scholarship haven't fostered a climate of open inquiry and big ideas? Who could've known?! 🤷♂️ theguardian.com/australia-news…
The genetic architecture of protein stability by @aj4re @ainamartiaranda @cristonah @ToniBeltran13 @JoernSchmiedel nature.com/articles/s4158… @CRGenomica @sangerinstitute @ALLOXbio
The AEpiA ECR Representatives are delighted to announce the winner of the 2024 Emma Whitelaw ECR Publication Award is 🥁🥁🥁.... ✨ Charles Bell @charles_bell92 ✨