Chen Davidovich
@DavidovichLab
Gene repression, RNA and all chromatin things. @MonashUni @EMBLAustralia
1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance? We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains. 🧵 biorxiv.org/content/10.110…
We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas. tinyurl.com/4yrwftrn
How we’re rebuilding the Weizmann Institute — and our hopes for a better future nature.com/articles/d4158…
Excited to share our MORC2 paper out in @NatureComms! Feel free to read the open access version here — rdcu.be/euihg
Excited to share the 1st preprint from @ShabihShakeel lab @WEHI_research on oncoprotein MORC2 that is now available on bioRxiv! Here’s a thread on our main findings on how MORC2 phosphorylation influences DNA compaction and its implications in cancer🔬📜 biorxiv.org/content/10.110…
RT please 🙌 Applications for a postdoctoral position in *Bioinformatics* in my lab are still open! Come and work with us @ARMI_Labs at the beautiful @cityofmelbourne Apply here careers.pageuppeople.com/513/cw/en/job/… Inquiries: [email protected]
Check out our (@Morpholosophist, @GATCLab and Alok Sinha ) thoughts on temperature sensing and response in plants out now @ScienceMagazine @MonashUni @MonashBiol @Monash_Science (1/4) science.org/doi/10.1126/sc…
🧵 1/ New preprint! How do transcription factors (TFs) use intrinsically disordered regions (IDRs) to find their target sites? biorxiv.org/content/10.110… #TranscriptionFactors #IDPs #SingleMolecule #Biophysics
Up next in #CLASS: Dr Evan Healy, Monash University. In this seminar Dr Healy will discuss ‘Dissecting the roles of Polycomb repressive complexes in stem and differentiated cells’. All welcome. Tuesday 20th May at 12pm
Australia completely lacks a dedicated training program for clinician scientists. With the vision and support of VMIAL @PeterMacCC is extremely proud to announce the first clinician-scientist fellowship. If you meet the eligibility criteria PLEASE APPLY! nature.com/naturecareers/…
Big thanks to @Addgene for making our MoClo Baculo available as a kit! All the plasmids for Golden Gate assembly of baculovirus vectors, now bundled together: addgene.org/kits/davidovic… #molecularcloning #baculovirus #ProteinExpression
GOOD MORNING AUSTRALIA! 🇦🇺 OSCAR PIASTRI JUST WON HIS SIXTH FORMULA 1® GRAND PRIX! 🏆 #MiamiGP #F1
"Single-molecule multimodal timing of in vivo mRNA synthesis" a collaboration with Rippei Hayashi's lab, work led by AJ Sethi @_AJSethi #RNA #premRNA #splicing #RNAprocessing #m6A #polyadenylation biorxiv.org/content/10.110…
🍺 Orchestrating epigenetics.... We have been working on SETD6 for a while now and I'm excited to share the review article we wrote 🧬 nature.com/articles/s1227…