Srinivasan Rengachari

Very pleased to share our work on the polyadenlyation-independent termination of Pol II by the helicase Sen1. nature.com/articles/s4159… Extremely grateful to the generous freedom and support of Patrick @mpgpresident for developing this work. A short 🧵 below.

Have you ever wondered how your back formed? The human embryo makes a neural tube (future spinal cord) and somites (trunk muscle/bone) from ~d20. They’re formed at the same time and place, so we used human Trunk-like Structures (hTLS) to investigate their ‘co-development’… (1/7)

Please RT. Post-doc opportunity alert! 💥 Come join our team (thelowlab.org) at Imperial, London, working on bacterial secretion systems. The position is funded by the Wellcome Trust. For more details and to apply please see imperial.ac.uk/jobs/search-jo…

❗️Exciting upcoming post-doc opportunity in the lab❗️🔔 If you have expertise in cryo-EM and bacterial secretion systems are your thing, then I’ll soon be advertising a long-term position funded by Wellcome Trust. Feel free to DM or email for early enquiries.. Thanks!

🚀 What if AI could accelerate scientific discoveries? Google’s AI ‘co-scientist’ could spot knowledge gaps, generate hypotheses, and transform research say @imperialcollege researchers 🔬🦠 Find out more ⤵️ imperial.ac.uk/news/261293/go…

Check out our lab’s latest work on the regulation of transcription by RECQL5 helicase! This work was co-led by @AlfredoFlorez07 and @nicklue8 , with contributions from Patricia Grob, Ben Kaeser, Jie Fang, and Susanne Kassube. 1/7 biorxiv.org/content/10.110…

Interested in joining our growing interdisciplinary team studying viruses, RNA, and condensates? Looking for a postdoctoral position? Please consider joining us in Cambridge, UK, or drop us a line to discuss these opportunities: jobs.cam.ac.uk/job/49901/

2024 saw another record for bioRxiv postings. Thanks to all the CSHL staff, affiliates, authors, funders, and everyone who advocates for the project. Happy New Year!

Skin has its own immune system nature.com/articles/s4158…

Crosslinks can sometimes improve AlphaFold3 models. Crosslinking is an experimental method often used as a source of distance restraints in modeling. In AlphaFold3, instead of using restraints, crosslinks can be included as covalent ligands. Thanks to @aobarska for the idea.

Women lose >90% of their #eggs by their mid-30s, with persistent #DNADamage driving this loss. But why isn’t this damage repaired? Our new work in @CurrentBiology, led by @ninadini_sharma, reveals the causes of high DNA damage in aged oocytes.🧬💥 bit.ly/48e35Ee (1/13)

Sensational structure! Mechanism of polyadenylation-independent RNA polymerase II termination | Nature Structural & Molecular Biology nature.com/articles/s4159…

A comprehensive review from @UmbertoAiello @DomenicoLibri and @OPorrua on Sen1. Its timely and complements this work out today: nature.com/articles/s4159…… Our work highly benefitted from the many contributions of Domenico and Odil to understand Sen1's functions in transcription.