Bede Portz

elifesciences.org/interviews/1c6…

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @CellCellPress, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. sciencedirect.com/science/articl…

1/ 🧬 How to Price a Platform in Biotech Q2 M&A is ripping, Capstan just cleared $2.1B at Phase 1, and something important has changed. A new market dynamic may be emerging, where optionality matters again. Let’s break it down with math, comps, and a framework 🧵

M6A-dependent RNA condensation underlies FUS autoregulation and can be harnessed for ALS therapy development | Science Advances science.org/doi/10.1126/sc…

Trump Administration Live Updates: Attorney General Alerted Trump His Name Appeared in Epstein Files nytimes.com/live/2025/07/2… via @NYTimes

E.P.A. Says It Will Eliminate Its Scientific Research Arm nytimes.com/2025/07/18/cli… via @NYTimes

Needless to say, the last 12 hours have been stunning for $SRPT. Shocking. Frustrating. Aggravating. Maddening. The fallout will impact gene therapy and all of biotech.

Design of intrinsically disordered region binding proteins | Science science.org/doi/10.1126/sc…

Excited to share my first postdoc paper in Cell! We found that BRD4 transcriptional condensates act as a pH-sensitive “switch” to fine-tune inflammation. Huge thanks to my amazing mentors & collaborators!@XuZhouLab @RMedzhitov @jkagan1 @Lo_Zanzi

Architectural RNAs: blueprints for functional membraneless organelle assembly dlvr.it/TLKTCW

Liquid-like transcription condensates locally constrain chromatin in living human cells biorxiv.org/content/10.110…

Our new work @biorxivpreprint 🔗biorxiv.org/cgi/content/sh… BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via bromodomain-mediated crosslinking: physical control of #chromatin by #LLPS transcription condensates. @semeigazin @katsu_s_minami @MasaAShimazoe

Nucleosome spacing can fine-tune higher-order chromatin assembly: nature.com/articles/s4146…

Amphiphilic protein surfactants reduce the interfacial tension of biomolecular condensates biorxiv.org/content/10.110… #biorxiv_biophys

More than 2700 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. biorxiv.org/content/10.110…

I'm also experimenting with SS; I've found X and BS getting pretty tedious these days, and SS to be a bit of a breath of fresh air. That said, this piece is likely way too long, and it's dangerous for me to have a longer form medium. srikosuri.substack.com/p/the-elusive-…

Imagine if the British won and we had to work today.

Dr. Katie is indeed a fantastic scientist and colleague. Excited for both of you and look forward to your discoveries.

Latest work on RNA condensation from the Banerjee lab, led by a superstar graduate student, Tharun Mahendran. Biomolecular condensates can enhance RNA percolation, leading to the emergence of multi-phasic RNA condensates. nature.com/articles/s4155…

CONGRATS Kevin!!!!

I stand with dozens of other biopharma leaders highlighting the potential catastrophic effects of proposed research cuts on bringing innovation to patients! statnews.com/2025/06/27/bio…