Christine Mayr
@Mayr_Christine
Scientist interested in 3′UTRs and cytoplasmic condensates. We study how mRNAs control IDR conformations and protein complex assembly @MSKCancerCenter, New York
Excited to share our latest work developing DART transgenic mice and using them to profile m6A in single cells of the mouse brain. A fantastic study led by Matt Tegowski with contributions from @TheHolleyLab nature.com/articles/s4159…
I've now compiled "30 Great Essays About Biology" into one article. Hopefully this will be a useful resource for students and others hoping to learn more about this field. Enjoy!
Excited to share our preprint on 3'UTR-chaperoned IDR functions!Check it out if you work on a protein with a long IDR and a highly conserved 3'UTR in the mRNA!
More than 2700 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. biorxiv.org/content/10.110…
More than 2700 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. biorxiv.org/content/10.110…
Wow! Amazing finding
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein go.nature.com/3YbT1In
Join us on April 24 for the #HIRM #RNA Medicine 10th Annual Symposium feat. One of our speakers @Mayr_Christine from @MSKCancerCenter Register now: lp.constantcontactpages.com/ev/reg/yy37udr… #HiRM @BIDMC_CancerCtr
Rapid and scalable personalized ASO screening in patient-derived organoids: nature.com/articles/s4158…
Site-saturation mutagenesis of 500 human protein domains: nature.com/articles/s4158…
1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! 🧵👇 nature.com/articles/s4158…
Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration: biorxiv.org/content/10.110…
How do cells transit from fate to fate? Quietly. @MITChemE
Cells transit through a quiescent-like state to convert to neurons at high rates biorxiv.org/cgi/content/sh… #biorxiv_sysbio
Excited to share that the AlphaFold 3 model code and weights are now available for academic use. Looking forward to seeing what new research this unlocks and how the research community builds on AlphaFold 3 for scientific discoveries github.com/google-deepmin… 1/2
Beyond thrilled to present our O-MAP—now *published* @naturemethods (!!!) O-MAP is a powerful new method for biochemically "dissecting" the subcellular microenvironment around an RNA of interest, using off-the-shelf parts and standard manipulations. 🧵 nature.com/articles/s4159…
Our latest paper is out! In collaboration with @DrAnneCarpenter, we conducted a systematic high-content screen to understand the role of protein mislocalization in diverse human disorders. 1/ cell.com/cell/fulltext/…
The final version of is now published: nature.com/articles/s4146… Congratulations @khorms57 and our team across 3 groups, ours, @FKHM, and @halfacrocodile!
Thanks to @vishvak2000 we are also releasing an RNA binding protein (RBP) browser for dynamic visualization of RBP-RBP interactions in our preprint (1/7) goodarzilab.shinyapps.io/RBP-Browser/
Our work on pooled protein recruitment is finally out @CellGenomics! cell.com/cell-genomics/…
Our platform for rapid manipulation of endogenous proteins at scale #SPOTLITES can be employed to discover novel effectors for #targetedproteindegradation #TPD and other proximity-based approaches! biorxiv.org/content/10.110…
Checkout the latest work from the lab online today in @MolecularCell where we find that distinct sequence features encoded in IDRs are responsible for targeting proteins to specific condensates. This work was led by @Nancybrillet @Prashan10011102 and @TvReshma .
Online Now: Disorder-mediated interactions target proteins to specific condensates dlvr.it/TCmWcp
G1 length dictates H3K27me3 landscapes biorxiv.org/content/10.110…
We present The Transcription Factor Binding Landscape of Mouse Development🐭🧬 #DevBio We use CUT&RUN-LoV-U to map Many SignalingPathways X 4tissue X 2stages It is a huge dataset - yet only the beginning of the TranscriptionFactorBinding(TFB)-OMICS biorxiv.org/content/10.110…