Priya R. Banerjee
@BanerjeeLab_UB
learning how macromolecular phase transitions program cellular functions. interested in single-molecule biophysics, disordered proteins and RNA.
How do RNAs phase separate without proteins? 💧💧🩸🩸 We are excited to share this story with you (preprint) "RNAs undergo phase transitions with lower critical solution temperatures". biorxiv.org/content/10.110… A longer thread will follow soon. @gable_wadsworth @PappulabWashU
In collaboration with @BanerjeeLab_UB, we dive a little deeper into the microscopic interactions and sequence patterns shaping condensate activation energies pubs.acs.org/doi/10.1021/ac…. For more context, see also our prior work science.org/doi/10.1126/sc…
Latest work on RNA condensation from the Banerjee lab, led by a superstar graduate student, Tharun Mahendran. Biomolecular condensates can enhance RNA percolation, leading to the emergence of multi-phasic RNA condensates. nature.com/articles/s4155…
Check out this tour de force study by Sangwoo Park and his incredible team of collaborators. Biophysical properties of single nucleosomes are responsible for A and B compartments in cell nucleus.
"Native nucleosomes know where to go!” Our Condense-seq paper is now published in Nature! 📄 nature.com/articles/s4158… I’m deeply grateful to my PhD advisor @taekjip and our incredible collaborators @MuirLab , @binzmit , Erika Pearce, and Ben Garcia lab!!
DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation: Cell cell.com/cell/fulltext/…
📢Excited to share our new paper in @NaturePhysics : Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular ciliate Stentor! How do single-celled organisms benefit from teamwork? Let’s dive in! #Multicellularity nature.com/articles/s4156…?
Happy to share our new preprint on small molecule mediated inhibition of aging of biomolecular condensates.
In our new preprint, we study the physical aging of biochemically active condensates formed by an engineered Tau protein into disease-linked amyloid fibrils — and investigate whether small molecules can counteract this transition. @BanerjeeLab_UB biorxiv.org/content/10.110… 🧵1/3
Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation doi.org/10.1101/2024.0…
Excited to see this (cover) article on condensates come out in Scientific American. Nice quotes from me and many folks in the field. scientificamerican.com/article/myster…
Meet the CALVADOS RNA model on bioRxiv or on 🦋
“I still believe that finding mind lodged in biological matter is the most profound question that physics can pose. And that the breadth of physics is a good base from which to begin.” This is what we believe too at @PRX_Life
This award is very hard to respond to. I have received many hundred congratulatory notes, from former students, post-docs, Princeton University juniors and seniors, funding agencies and foundations, authors, signature collectors, amateurs, elementary school neural network…
The #APS deadline for abstracts has been extended to Oct 31! This is an excellent venue to showcase your work if you work in computational/experimental cellular biophysics featuring biomolecular condensates. Co-organized together with @hbozhao, Yaojun Zhang, Patrick McCall
📢New paper alert!! With @boothbylab @alexholehouse @fried_lab we take a look at how an entire proteome survives desiccation. TLDR: Desiccation tolerance is encoded in specific residues on the protein surface, and occurs primarily in biosynthetic enzymes. shorturl.at/U5VS1
RNA-driven phase transitions in biomolecular condensates. In this review or our #RNA focus issue, @BanerjeeLab_UB and colleagues take an RNA centric view of understanding ribonucleoprotein condensates. dlvr.it/TF3BLc
Our focus issue on RNA biology features reviews that explore the many faces of #RNA, diving into the processes mediating the lifecycle of RNA, the regulatory roles of RNA, the importance of RNA in disease, and the technologies used to study RNA. cell.com/molecular-cell…
Our review on RNA-driven phase transitions is up today at Molecular Cell! Check it out! @BanerjeeLab_UB cell.com/molecular-cell…
How do you turn a condensate inside-out? Congrats to @sofiquinodoz & @jiang_lifei & co-authors on amazing study from our lab & @LafontaineLab + Klinge. Genomics, engineered nucleoli, & modeling RNA-controlled nucleolar architecture!! (Tweetorial soon!) biorxiv.org/content/10.110…
Out today in @MolecularCell Our review article highlights recent advances in ribonucleoprotein condensate biology, focusing on RNA-driven phase transitions. Efforts led by @gable_wadsworth and Sukanya Srinivasan. authors.elsevier.com/a/1jt7A_Oylrla…
So glad to see this work in prints. RNA-based biomaterial are so exciting!! We @gable_wadsworth played a small role in this collaborative work with @JulieNguyenLab. sciencedirect.com/science/articl…