Junjie Guo 郭俊傑
@guo_lab
Assc Prof @YaleNeuro • coDGS @Yale_INP • @YaleRNA • @WuTsaiYale • All things RNA • Immigrant • 🐶 dad • @WhiteheadInst @HopkinsNeuro @PKU1898 alum 🏳️🌈
In @NatureGenet we report that base editing of trinucleotide repeats (TNRs) reduces somatic repeat expansions in Huntington’s disease (HD) and Friedreich’s ataxia (FRDA)—in patient-derived cells and in vivo—a collaboration with the Mouro Pinto lab. drive.google.com/file/d/1on7kdy… 1/14
My lab has postdoc openings in the following areas: 1) Structural biology and single molecule biophysics; 2) Developing novel genome editing methods; and 3) Protein and RNA engineering. Please share the info with your trainees, and RT please. 🙏 postdocs.yale.edu/yale-postdocto…
While I’m a big fan of new technologies that help us study human biology…there’s still no replacement for animal research! I wrote an article outlining this in @GENbio genengnews.com/topics/transla…
Congratulations to Denethi Wijegunawardana @Yale_INP @YaleNeuro for passing her PhD thesis prospectus with valuable inputs from @MattGirgenti @JanghooLim and Steve Strittmatter!

Excited to welcome Dr. Katie Copley as a new postdoc in our lab @YaleNeuro! She recently completed her PhD in @ShorterLab and did amazing work on designing small RNA chaperones to counteract TDP-43 pathology in ALS-FTD.

Targeting a lncRNA to treat neurodevelopmental disorders. Congrats @IgorUlitsky!
Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share: "Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression". A 🧵biorxiv.org/content/early/…
Congratulations to the freshest @Yale_INP PhDs from the lab, 🎓Paul Lee and 🎓Suzhou Yang! #Yale2025

Excited to organize this CSHL Asia meeting with @pengjinATL on Repeat Expansion Disorders. Hope you all can join us!
Cold Spring Harbor Asia Meeting - Short Tandem Repeats in Gene Regulation and Disease @CSHANews csh-asia.org/?content/2754
Please RETWEET! 2 postdocs (one chemical biologist, one RNA biologist) and multiple PhD positions are available at #KwokLab, City University of Hong Kong. We work on #RNA, #Gquadruplex, #aptamer , #peptide, #Biosensor and more! See kitkwok.com . PM if interested.
Had so much fun visiting and talking RNA and neuroscience with @SikaZheng @UcrRNAcenter and his colleagues at the Institute for Integrative Genome Biology @UCRSoM!


Morning dog walk in Wooster square, New Haven 🌸🌸🌸 #cherryblossom
Thrilled to see the 2025 Yale Kavli Postdoc Fellows announced! Huge congrats to Zhen Lei and Madeleine Junkins—your work is inspiring, and we’re proud to support the institute that helps make it possible! #KavliNeuro #KavliInstitute
🥳 Congrats to Zhen Lei @Ray32364897 (@guo_lab & David Breslow) and Madeleine Junkins (@RMedzhitov & Rui Chang) for being awarded the 2025 Kavli Postdoc Fellowship 🏆—pushing neuroscience forward through interdisciplinary, dual-mentored research! medicine.yale.edu/kavli/news-art…
🥳 Congrats to Zhen Lei @Ray32364897 (@guo_lab & David Breslow) and Madeleine Junkins (@RMedzhitov & Rui Chang) for being awarded the 2025 Kavli Postdoc Fellowship 🏆—pushing neuroscience forward through interdisciplinary, dual-mentored research! medicine.yale.edu/kavli/news-art…
🎉 Meet @suzhou_yang — this week’s #TraineeTuesday! Suzhou is a Ph.D. candidate in the @guo_lab who just defended his thesis 🙌 With his groundbreaking work soon to be published, let’s explore his story! 🔬📚 [1/5]
The Sorrells Lab is hiring a recent college graduate interested in neurobiology of mosquitoes! The position is ideal for someone interested in gaining skills for graduate school. Apply here: apply.interfolio.com/164849
Congratulations to our @Yale_INP director Marina Picciotto @MarinaP63 ! 🎉🎉🎉
Congratulations to our new president-elect, Marina Picciotto of @Yale! AAAS Members also elected Gabriela Popescu of the University at Buffalo and Roger Wakimoto of @UCLA to the Board of Directors. aaas.org/news/neuroscie…
Congratulations 🎉 to PhD #2 in the lab, Dr. Suzhou Yang, for successfully defending his thesis! Stay tuned for his nice paper on #c9orf72 #mRNA splicing 🧬 in #als and #ftd 🧠 @Yale_INP @YaleNeuro


Today is a big day for two of our @YaleNeuro grad students! Join us to support 🤝 @Yale_INP's Yue Fei @YueFei80354181 from the @liangl02 lab and Suzhou Yang from the @guo_lab as they defend their theses!✍️ Soon Ph-inishe-D! 🙌 (Check your emails for more info on when and where)