Thomas Vierbuchen

Excited to share our latest manuscript, a collaboration with @JustinPerryPhD led by @WeillCornell neuroscience PhD student @AnnBaako. Ann developed a new, improved mouse PSC model for studying tissue-resident macrophage differentiation. biorxiv.org/content/10.110…

Really excited about this collaboration with Twist for extremely high-throughput genotyping via a library prep kit (and capture probes) plus analytics businesswire.com/news/home/2024…

Here's an embryonic tortoise (~30 days old) developing within its egg 🐢🔬

Using MRI images from 72 modern breed dogs & 13 premodern dogs: Modern breeds have expansions of neocortex & reductions in the amygdala & other subcortical regions. Cortical measures predicted individual variation in trainability & amygdala differences predicted fear scores. ...

Hear it straight from our amazing first author @_annhuang to dive into the X-Atlas/Orion dataset and the FiCS Perturb-seq Platform. Excited to share our work from @Xaira_Thera. (biorxiv.org/content/10.110…)

Plasmid-based reporter assays are the bedrock of regulatory genomics. But a basic question has gone unanswered for decades: Do chromatin architectures form on plasmids transfected into mammalian cells—and does it matter? We finally have answers. biorxiv.org/content/10.110…

Modeling tissue-resident macrophage development from mouse pluripotent stem cells biorxiv.org/content/10.110… #biorxiv_devbio

The latest work out of @WeillCornell proposes that genetic variants represent biomarkers to identify #pluripotent cell lines with desirable properties and may allow the targeted engineering of naive #PSCs with stable epigenomes. 🔗 @stemcellreports | bit.ly/3DHaeSR

New study shows genetic variation affects DNA #hypomethylation & imprint deregulation in naïve PSCs. Genetic variants may be potential biomarkers for epigenetically stable PSCs. ow.ly/aCVY50VilVY @WCM_MeyerCancer @WeillCornell @UMassChan @MSKCancerCenter @ISSCR

Beautiful work by the Stadtfeld and @TommyVierbuchen labs on the role of genetic variation on imprinting and dna methylation stability in mouse pluripotent stem cells cell.com/stem-cell-repo…

Assistant, Associate or full Professor tenure-track faculty position job with Icahn School of Medicine at Mount Sinai - Institute for Regenerative Medicine | 666758 jobs.sciencecareers.org/job/666758/ass…

Excited to share our latest preprint, as part of ENCODE4, on a consensus variant-to-function (cV2F) score for functionally prioritizing variants for complex disease - led by Tabassum Fabiha and co-mentored with Alkes Price. biorxiv.org/content/10.110…

Excited to share our new preprint in which we address: (1) Accurate sequencing of sperm at scale (2) Positive selection of spermatogenesis driver mutations across the exome (3) Offspring disease risks from male reproductive aging [1/15] medrxiv.org/content/10.110…

Congratulations Laura to the award and your fantastic work!

Incredibly proud of PhD student @htanudisastro from my team, who just gave a fantastic #ASHG24 talk on the impact of tandem repeat variation on cell type-specific expression. Check out her preprint: biorxiv.org/content/10.110…

Looking forward to ASHG this week! I will be presenting work led by @aabiddanda and @saracarioscia using data from >100,000 IVF embryos to discover genetic variants influencing meiotic recombination and aneuploidy at the opening session on Tuesday evening. #ASHG24 🧬🏔️

📢 New preprint alert: We’ve just published a deep dive into the role of tandem repeats (#TRs) in single-cell gene expression across the immune system, using #WGS and #scRNA-seq data from 1,790 individuals and over 5 million blood cells! 🧬 🧵👇 #repeats #SingleCell 1/9

How it started vs. how it's going, halloween edition

Exciting science and amazing scenery at @jacksonlab Diversity in a Dish meeting this week.

In this joint collection @CellStemCell and @stemcellreports (@ISSCR) come together to share a collection on neuroscience models. Read now: hubs.li/Q02SV_kd0 @martinperaJAX