Stergachis Lab

@stergachislab

We do not know the function of the far majority of our genome, limiting our ability to diagnose and treat patients. Our lab seeks to solve this.

University of Washington

Joined March 2023

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Stergachis Lab@stergachislab · Nov 7

Deaminase-assisted Fiber-seq (DAF-seq) has arrived! DAF-seq is an amplification-compatible version of #Fiberseq that resolves genetic and chromatin architectures with single-nucleotide, single-molecule, single-haplotype, and single-cell precision. biorxiv.org/content/10.110…

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Stergachis Lab Retweeted

Danilo Dubocanin@DubocDan · Mar 24

I’m excited to share the first manuscript out of my PhD work with @NAltemose, in which we describe FiberFold: a deep learning tool that predicts cell-type-specific and haplotype-specific 3D genome organization from a single experiment! biorxiv.org/content/10.110… 1/

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Stergachis Lab@stergachislab · Feb 2

The next generation approach for how we resolve the genetic and molecular basis of rare diseases. A wonderful collaboration between clinical teams @UDNconnect, academic teams, and @PacBio. Thanks @NHGRI_Director, @BrotmanBaty, BWF, and Pew for the funding. nature.com/articles/s4158…

stergachislab's tweet card. Nature Genetics - Simultaneous profiling of the genome, methylome, epigenome and transcriptome using single-molecule chromatin fiber sequencing and multiplexed arrays isoform sequencing identifies...

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Stergachis Lab@stergachislab · Jul 20, 2024

Are CpG methylation and chromatin accessibility polar opposites? #Fiberseq proves they are not in #maize – transposon enhancers can have simultaneous single-molecule hyper-mCpG AND chromatin accessibility. Wonderful collaboration w/ Queitsch lab & @RNAnerd biorxiv.org/content/10.110…

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