Carlos E Alvarez
@CarlosEAlvare17
I study complex genetics & molecular pharmacology. Interests include canine-human comparative genomics of behavior, cancer & pleiotropy; & alpha arrestins.
We mitigate scientific risk by incremental advances. Yet when we say “high-risk, high-reward,” we still try to measure likelihood of success despite knowing that, in a few years, the context & assumptions will be wrong. That’s why the question matters more than the justification.
The best performers threaten the establishment and the most enlightened managers don’t just see what’s broken but they challenge it. Institutions live in constant fear of those with the most integrity, because they see what truly serves the mission and what corrupts it.
Students think they’re dismantling power. In reality, they’re helping administrators purge the remaining original minds.
RIP Ozzy ..I need someone to show me the things in life that I can't find I can't see the things that make true happiness, I must be blind ..& so as you hear these words telling you now of my state I tell you to enjoy life I wish I could but it's too late -Paranoid (B Sabbath)
GDF15 is the best biomarker of energetic stress and energy resistance (éR) New paper showing that GDF15 is on average elevated people with diagnoses of schizophrenia (+61%), bipolar disease (+56%), and major depressive disorder (+82%) Consistent with the notion that mental…
Not the meek! I said the geek will inherit the earth.
Nvidia CEO Jensen Huang just made the boldest prediction of his career: “AI will create more millionaires in 5 years than the internet did in 20.” But he didn’t stop there. He revealed exactly HOW it’ll happen Here’s his framework for capitalizing before it’s too late: ⬇️
In the dawn of the genomics era (which I'm not sure ended yet 😂), Step 1 was to throw out the mitochondria & ribosomes, not just forsaken for being too loud, but derided as "boring"! Turns out our bottom-up strategy was to discard the main characters before reading the plot.
Some of what makes each of us unique is likely to be expressed in mitochondria Discussion on a new paper here: mitoworld.org/how-evolution-… The paper: cell.com/cms/10.1016/j.… Probing the role of mitochondria as driver of psychobiological differences in humans:…
It's ironic that it's about inference of new prompt patterns that were absent in the training, then the abstract provides the full form of LLM but not its most important term, MLP, which was used there three times.
Learning without training Google researchers explore the implicit dynamics of in-context learning. "Implicit weight updates from ICL mirror the effect of actual fine-tuning on the same data." This one is more technical but much needed. The findings:
Interested in love and mate preferences? Our dataset includes responses from 117,293 participants across 175 countries. You're welcome to use it for your own research! Paper and dataset linked below. @ with amazing collaborators from the large-scale cross-cultural consortium <3
How challenging is the prediction of transcriptional responses to CRISPR gene perturbations ? A simple model, just scaling RNA correlation vectors, results in accurate predictions for many perturbations. The model is intuitive & grounded in a simple approximation. 1/2
Why? Because reviewers would ask for additional experiments to really nail down the negative results, maybe suggest many new conditions and methodologies? 😆😆
Scientists overwhelmingly recognize the value of sharing null results, but rarely publish them in the research literature go.nature.com/472poOC
Thrilled to share our new Perspective paper just published in Nature Biomedical Engineering. We explore how EEG-based connectomes, when combined with AI/ML, multimodal imaging, and closed-loop neuromodulation, can power the next generation of precision neuroscience and psychiatry
So much detail to ponder - biological and biomedical contexts! Eg, translocations & their effects; or that genomes w African ancestry have, on average, 468 more paralogous genes (n = 21,595 total genes) when compared with genomes of non-African individuals.
Complex genetic variation in nearly complete human genomes | Nature nature.com/articles/s4158…
1/ 🚨 Our new paper is online in @Nature ! As its first author, I’m enthusiastic to finally share it with you all!🎉 🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤 👉 nature.com/articles/s4158… @OxfordDPAG 🧵👇
Great idea!
Ginkgo has launched an E.coli-based Cell Free Protein Synthesis reagent! reagents.ginkgo.bio/products/cell-…
One of the most alarming facets of the Favorite Gene Era, which largely continues, is that the general unit of study wasn’t even the favorite gene. Investigators could spend whole careers on one isoform in one cell line. Yet we still don’t know what every gene in E. coli does.
Single cell and spatial alternative splicing analysis with Nanopore long read sequencing nature.com/articles/s4146…