Trevor Zandi

biorxiv.org/content/10.110… Compounds that recruit FKBP12 to novel targets with high cooperativity are the prototypical molecular glue and, represented by sirolimus and tacrolimus, have had major clinical impact. 1/3

Seeking patients with myxoid leiomyosarcoma featuring a PLAG1 fusion. We're forming a major foundation with the best minds including @drsarcoma to find treatments and a cure for this rare disease, including developing in-vitro tumor models. Know someone affected? Pls reach out!

I'm happy and humbled to take on a new role with @buildmodels . I'll be continuing @dsgoodsell's work on the Molecule of the Month, starting with my first article on Assembly Line Polyketide Synthases! Check it out (animation included!) pdb101.rcsb.org/motm/301

Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells! biorxiv.org/cgi/content/sh…

Congratulations to Google Deep Mind and our partners at Isomorphic Labs for the remarkable development of Alphafold 3 (nature.com/articles/s4158…) which now has greatly enhanced ability to model proteins in complex with multiple binding partners including DNA, RNA and small molecule…

AlphaFold 3 is out! As expected expands coverage to small molecules and nucleic acids. And replaces the structure module with a diffusion-based one. Unfortunately no code or model weights--just a web server for a limited set of ligands: blog.google/technology/ai/…

wsj.com/business/autos… Vehicle safety is important to me for personal reasons, so these numbers sound concerning! However, I wish the writers of such stories lessons followed physical chemists and used a reference state, i.e. comparable numbers of incidents without “Autopilot”.

📍 Thanks for having us, @bplmaps! Stop by this Friday anytime between 2–4:00pm to view historic maps of the MBTA's most-troubled routes. 🚍 Visitors will also get a sneak peek of the slowest & most bunched buses. Full report coming soon 👀

So excited to be co-organizing the 2024 Symposium for #StructuralProteomics with @FJ_OReilly & @Malvina_Pap at @broadinstitute in October! Save the date (28-30 Oct) for this event bringing together leaders in structural mass spec, cryoET, comp. structure prediction, and more!

More to follow – honored and humbled to have this opportunity but will never lose sight of the patients we are doing this for and the challenges we face. nytimes.com/2024/01/12/bus…

Interesting read in @NatRevDrugDisc on the potential of innovative trial design for evaluating repurposed drugs nature.com/articles/d4157…

With a chemical biology mindset, truly nothing is undruggable. Here, the active state of KRAS via modified Cyclophilin A ligands. Have been looking forward to seeing this in print. Congratulations, RevMed. science.org/doi/10.1126/sc…

Caught a couple of Northern Pygmy owls today. They were quite accommodating.

Albert Eschenmoser taught us whole new ways to think about organic chemistry – from orbitals, to mechanisms, to syntheses, to life processes, and eventually even to the origins of life. His passing marks the end of an era defined by his intellectual brilliance. 💔

New paper from ⁦@SchreiberStuart⁩: Bifunctional small molecules that induce nuclear localization and targeted transcriptional regulation | bioRxiv biorxiv.org/content/10.110…

Appearing today in @J_A_C_S. Connecting the dots to a biogenetic proposal for anthraquinone-fused enediyne biosynthesis: doi.org/10.1021/jacs.3… Remarkable rearrangement and oxidation chemistry — and a simple, efficient synthetic model. Congratulations Paramita and Serena!

Great to see a key technical challenge met… accompanied with a striking, by-eye visualization!