CellChemicalBiology

@CellChemBiol

Cell Chemical Biology is a #chemicalbiology journal from @CellPressNews. Editor-in-Chief @DeyMishtu

Cambridge, MA

Joined April 2014

773Following

7KFollowers

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CellChemicalBiology@CellChemBiol · May 15

The May Issue of @CellChemBiol is now online! Click here to read more: dlvr.it/TKnNm6

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CellChemicalBiology@CellChemBiol · Jul 18

Site-resolved assessment of targeted protein degradation dlvr.it/TM0FmL

CellChemBiol's tweet card. Moreno Ballesteros et al. introduce a site-resolved strategy combining genetic code expansion and bioorthogonal chemistry to evaluate how ligand binding sites influence targeted protein degradation....

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CellChemicalBiology@CellChemBiol · Jul 18

A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner dlvr.it/TM0ChJ

CellChemBiol's tweet card. Sylvain et al. identified NK7-902, a potent NEK7 degrader. While NK7-902 effectively degrades NEK7 in human and murine systems, inhibition of NLRP3 activity varies by context. This study deepens...

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CellChemicalBiology@CellChemBiol · Jul 18

Covalent inhibition of ACSL4 alleviates ferroptosis-induced acute liver injury dlvr.it/TM09Nc

CellChemBiol's tweet card. Linghu et al. demonstrate that Rociletinib covalently binds to cysteine 170 of ACSL4, inhibiting its activity to suppress lipid peroxidation and ferroptosis, thereby alleviating ferroptosis-mediated...

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CellChemicalBiology@CellChemBiol · Jul 18

Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity dlvr.it/TM06dL

CellChemBiol's tweet card. Nardella et al. repurposed a kinase inhibitor for malaria treatment, addressing the challenge posed by Plasmodium falciparum’s resistance to most existing antimalarial drugs. The inhibitor targets...

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CellChemicalBiology@CellChemBiol · Jul 18

Silencing stress: Structural insights into ISR termination by the SIFI ubiquitin ligase dlvr.it/TM03Rt

CellChemBiol's tweet card. The E3 ligase complex SIFI silences the integrated stress response (ISR) by targeting stress-induced proteins for degradation. In the May 6th issue of Nature, Yang et al. revealed how this megadalton...

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CellChemicalBiology@CellChemBiol · Jul 18

Powering the powerhouse: Mitochondrial NADPH propels oxidative metabolism dlvr.it/TM00Qw

CellChemBiol's tweet card. Mitochondrial NADPH is abundant, but the reason why was uncertain. In a study published in Nature Cell Biology, Kim et al. identified an important role of NADK2-derived mitochondrial NADPH in...

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CellChemicalBiology@CellChemBiol · Jul 18

Ribosomal RNA transcription regulates splicing through ribosomal protein RPL22 dlvr.it/TLzxPx

CellChemBiol's tweet card. Fan et al. uncovered a mechanism linking rRNA synthesis to spliceosomal regulation. Using large-scale cancer cell line screens with specific RNA polymerase I inhibitors, they identified a non-canon...

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CellChemicalBiology@CellChemBiol · Jul 18

RPL22 links ribosome biogenesis, RNA splicing, and sensitivity to RNA polymerase I inhibition dlvr.it/TLzt3P

CellChemBiol's tweet card. In this issue of Cell Chemical Biology, Fan et al. identify that mutations in the ribosomal protein RPL22 confer sensitivity to RNA polymerase I inhibitors. RPL22 regulates MDM4 function and cell...

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CellChemicalBiology@CellChemBiol · Jul 17

The July issue of @CellChemBiol is now live. Read the full issue here: dlvr.it/TLzFF8

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CellChemicalBiology Retweeted

St. Jude Research@StJudeResearch · Jul 14

Attend the 2025 Bringing Chemistry to Medicine Symposium to learn from leading experts in transcription, chromatin regulation, computational biology and chemical biology. Registration is free and available both in-person and virtually.

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CellChemicalBiology@CellChemBiol · Jul 14

Online now! A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner dlvr.it/TLvvTQ #chembiol

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CellChemicalBiology@CellChemBiol · Jul 9

Online now! Covalent inhibition of ACSL4 alleviates ferroptosis-induced acute liver injury dlvr.it/TLqNRr #chembiol

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CellChemicalBiology@CellChemBiol · Jul 8

Online now! Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity dlvr.it/TLpFqX #chembiol

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CellChemicalBiology@CellChemBiol · Jul 7

Online now! Site-resolved assessment of targeted protein degradation dlvr.it/TLn8Bk #chembiol

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CellChemicalBiology@CellChemBiol · Jun 20

Electrochemical sensor toolkit for simultaneous glutamate detection at edge of cleft and peri-soma dlvr.it/TLT2dC

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CellChemicalBiology@CellChemBiol · Jun 20

A cationic amphiphilic drug synergizes with strobilurin fungicides to control fungal-borne plant diseases dlvr.it/TLSzyL

CellChemBiol's tweet card. Laflamme et al. identified CMLD009688 as a compound with activity against the plant fungal pathogen Fusarium graminearum. The authors characterize CMLD009688 as a cationic amphiphile that perturbs...

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CellChemicalBiology@CellChemBiol · Jun 20

Mechanism by which the molecular glue-like verteporfin induces IRE1α dimerization and activation to synergize with AKT inhibition in breast cancer dlvr.it/TLSx6C

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CellChemicalBiology@CellChemBiol · Jun 20

Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation dlvr.it/TLSstW

CellChemBiol's tweet card. In this study, Baro et al. present a mechanistic approach for the partial inhibition of N-glycosylation, which enables the delivery of bioavailable small molecules exhibiting anti-tumor activity in...

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CellChemicalBiology@CellChemBiol · Jun 20

EGR2 O-GlcNAcylation orchestrates the development of protumoral macrophages to limit CD8+ T cell antitumor responses dlvr.it/TLSpm5

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CellChemicalBiology@CellChemBiol · Jun 20

Charting the development and engineering of CRISPR base editors: lessons and inspirations dlvr.it/TLSlgx

CellChemBiol's tweet card. CRISPR base editors (BEs) are genome editing tools that enable precise nucleotide changes without relying on double-stranded breaks. Zou et al. reviewed the history of BE development and discussed...

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