Peggy Hsu MD PhD
@PeggyPHsu
Oncologist-scientist @UMRogelCancer | Lung cancer, ALK, organoids, cell fate, metabolism
Hard to compete with the Nobel prizes (!!!) today but proud to share our preprint (by a fun team of @TheSpenceLab, Ansley Conchola, Tristan Frum + many others) where we present a cellularly-resolved map of the developing human lung, identifying a human-specific LGR5+ basal cell.
Excited to share our latest preprint: A spatially-resolved blueprint of the developing human lung reveals a WNT-driven niche for basal stem cells. biorxiv.org/content/10.110… Led by a talented team: @PeggyPHsu, Tristan Frum and Ansley Conchola - and with many other contributors!
Diet/microbes place the gut epithelium as a nexus for evolutionary change. With @TheSpenceLab @genomeCraig, we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @ScienceMagazine #evodevo 🧵1/11 science.org/doi/10.1126/sc…
Attending the 2025 ALK+ Summit? 💉 Be part of groundbreaking research! Join the blood draw & support the Judith Tam @UMRogelCancer ALK Lung Cancer Research Initiative — aimed at stopping progression & resistance before it starts. 📩 Check email to pre-register now. 💪
A seed grant from the Forbes Institute for Cancer Discovery helped @NagrathSunitha explore a provocative idea: why were patients with DCIS developing metastases decades later: michmed.org/kVKbX @UMichChE #bcsm
World Lung Cancer Day is coming up on August 1! We are raising awareness and standing with everyone impacted—because lung cancer doesn’t discriminate. If you have lungs, you can get lung cancer. 🦋🫁 #WorldLungCancerDay #FreeToBreatheWalk #LungCancerAwareness
Why do some genetic mutations devastate specific tissues while sparing others? We explore this question in GGC repeat disorders, revealing a mechanism linking protein aggregation to tRNA splicing failure in the brain. 🧵 on our new paper in Science: 🔗 science.org/doi/10.1126/sc…
Proudly presenting Simon’s paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism @NatMetabolism nature.com/articles/s4225… @helsinkiuni @HiLIFE_helsinki @SuomenAkatemia @MetaStem_Center
Valuable cell lines that are key to research are being sold at bargain basement prices as the California Institute for Regenerative Medicine divests itself of its collection of induced pluripotent stem cells. Time is running out, @JonathanWosen reports. statnews.com/2025/07/11/ste…
Several of LCRF's staff visited the University of Michigan this week to tour Dr. Peggy Hsu’s lab and enhance the broader ALK initiative. Our team, along with members of the Murgatroyd family of ResearchALKay+ and other LCRF supporters, was honored to meet researchers, tour…
Lysophosphatidic acid and sphingosine-1-phosphate are apical polarity cues in multiple organoid systems dlvr.it/TLHrf6
About 70K people in the U.S. are living with ALK+ lung cancer—most diagnosed at Stage IV. 🎯 Early detection + targeted therapy = longer lives. Now’s the time: Every gift is DOUBLED to fuel research. Join us: secure.qgiv.com/event/alkposit… #PoweredByPatients #ALKPositive #APAM2025
So honored to receive a BWF CAMS and thankful to all of my mentors and supporters along the way! BWF Announces 2025 Career Awards for Medical Scientists bwfund.org/news/bwf-annou…
Mesenchymal (vimentin+) circulating tumor cells (#CTCs) may be progostic for progression in ALK+ #NSCLC. Great to see more non-invasive tests for progression. Collaboration between @NagrathSunitha Dr. Yuru Chen & Dr. Angel Qin @UMRogelCancer #AACR25 @ALKPositiveinc
🚨 pleased to share a new preprint made possible through a great collaboration with the @melissa_skala & @SeanPalecek labs! can medium composition impact the behavior of hPSC-derived cardiomyocytes? Andy and Aaron co-led efforts to tackle this Q w/HPLM! tinyurl.com/ux2arjw8
🔥Smoking hot new paper and tweetorial from @DJCalebC (collab with @ArulChinnaiyan)! 🔥 We are over the moon about this new work and its therapeutic implications for pancreatic cancer. Please have a read and share your thoughts/feedback! 🙏🏼
Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@LyssiotisLab @ArulChinnaiyan), has just been published in @Nature! @UMRogelCancer @UMICHpancreas @UMichMedSchool @UMichPath @UMichResearch @UMichCMB
Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@LyssiotisLab @ArulChinnaiyan), has just been published in @Nature! @UMRogelCancer @UMICHpancreas @UMichMedSchool @UMichPath @UMichResearch @UMichCMB
nature.com/articles/s4155… New work from the group is now ONLINE at @NatureCellBio! Originally tweet-threaded here: x.com/DelgoffeLab/st…
New preprint from the lab is online! The product of a stellar collaboration with @Muir_Lab, we explore a chemically defined physiologic media formulation based of the metabolite of tumor interstitial fluid (TIF, or “tumor juice”) and its effects on T cell function! A brief 🧵1/
Not all Lung adenocarcinomas (LUAD) respond the same. 📊Mucinous LUAD = 10% of cases, often KRAS+, TTF1–, PD-L1 low Worse outcomes across therapies: ICI ORR: 8.4% vs 25.9% IO+chemo OS: 11.4 vs 19.6 mo KRASG12C OS: 6.8 vs 10.8 mo Histology matters #LungCancer #NSCLC #KRAS
Congratulations to Matthew Meyerson, MD, PhD, FAACR, @DrChoueiri, and Alice T. Shaw, MD, PhD, recipients of @AACR 2025 Scientific Achievement Awards. @DanaFarber Read more here: bit.ly/4j7m8om
What if a leukemia drug could help treat ALK+ lung cancer? A new trial at @UMRogelCancerCtr is exploring gilteritinib—FDA-approved for leukemia—as a way to overcome resistance in ALK+ NSCLC. 🔗 Read the story: alkpositive.org/blog/2024/5/22… #DrugRepurposing #ALKPositive
Happy to share our most recent review on mitochondria-organelle metabolic communication with @YatrikShahLab and @LyssiotisLab!! We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals! sciencedirect.com/science/articl…