Brandon Chen, PhD
@BrandonTWChen
@theNCI K00postdoc with @KivancBirsoy |PhD with @Lyssiotislab & @Yatrikshahlab | organelle & metabolism
Happy to share our new work where we took a deep dive into ER-mito contact sites and metabolic cell bio! Thanks to all the authors and most importantly @YatrikShahLab and @LyssiotisLab for their support. I will share some snippets of this journey from my perspective (🧵👇) (1/n)
BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III biorxiv.org/cgi/content/sh… #biorxiv_cellbio
Happy Friday! @LyssiotisLab and I had a fun time hyping up our favorite metabolite Uridine as the Metabolite of the Month in @CellCellPress! We hope you enjoy this quick read! cell.com/trends/endocri…
If you are in the Midwest and ❤️ metabolism, take note! This year’s Midwest Metabolism meeting will be held jointly with the Translational Research in Mitochondrial Metabolism in Aging and Disease (TRiMAD) conference. The combined 2-day event will be @umichmedicine, with…
Thrilled to announce that I will be joining the Cardiovascular Research Institute at @IcahnMountSinai as an Assistant Professor in January! My laboratory will focus on nutrient transport and cellular metabolism in physiology and disease.
Congratulations @LyssiotisLab! Glad to be part of the team during my PhD! To the next decade and more🥂!
It’s been a decade - Happy 10 year Labiversary @LyssiotisLab 🎉🥳 Thank you to all have who been along on the journey 🙏🏼 @UMPhysiology, @UMRogelCancer, @UMICHpancreas
As promised, a 🧵 on our recent article now out in @NatureSMB! Co-led with @AbbyBartlett_ @Pagliarini_Lab @JudithSimcox, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯#lipidtime doi.org/10.1038/s41594…
🚨🎉 Thrilled to share my first paper - now out in @Nature! Incredibly grateful to @JaviGBermudez for his mentorship and the support of our @CRI_UTSW community. Excited to keep pushing this work forward in the lab!
My lab's first paper is out in @Nature. We show that lipoprotein uptake protects tumors from ferroptosis by delivering the lipid antioxidant α-tocopherol. Surprisingly, tumors use sulfated glycosaminoglycans—not canonical receptors—to capture lipoproteins. nature.com/articles/s4158…
My lab's first paper is out in @Nature. We show that lipoprotein uptake protects tumors from ferroptosis by delivering the lipid antioxidant α-tocopherol. Surprisingly, tumors use sulfated glycosaminoglycans—not canonical receptors—to capture lipoproteins. nature.com/articles/s4158…
Online today in @Nature - our latest study led by superstar postdoc @GillesRademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s4158… full text available here 👉 rdcu.be/em0VG and thread 👇
We are delighted to share our new study on metabolic dependencies in group-3 medulloblastoma! Thanks to an awesome team of collaborators who made this possible! @LyssiotisLab @YatrikShahLab @sontagfdn @CarlKoschmann @SophiaLunt @UMRogelCancer @UMichPath cell.com/cancer-cell/ab…
We will be welcoming nine talented Graduate Student Rising Stars to share their research with us on Monday May 19th, starting at 9:30am in HSEB 1730. The symposium will be followed by the Pace Keynote talk by Dr. Toto Olivera at 4pm!
#Preprint alert! @KevinYTChen, a brilliant @GSKGradSchool graduate student and NCI F99/K00 awardee, identifies a novel, post-transcriptional checkpoint on intratumoral T cell function: biorxiv.org/content/10.110…
excited to share our latest work now online @NatMetabolism, led by @kyle_flickinger, where we unravel a mechanistic basis for the conditional essentiality of NADK, one of the many interesting hits from our previously reported CRISPR screening with HPLM rdcu.be/ekpu6
The Sable Award lecture at METPHYS2025 was really remarkable! Tremendous congratulations to this years exceptional member of our community @KivancBirsoy
We’re up! Come through in the next few hours to hang out! Section 12 board 12
My team and I are at #AACR25 and have posters to discuss parts of the project (and some future directions) tomorrow! Rüya Pakkan will present on Tuesday AM Abstract #4158 Sec 13 board 8. I will present on Tuesday PM #5384 Sec 12 board 12. Come visit!
Big shout out to @DJCalebC for this impressive body of work! One of the smartest and grittiest scientist I've ever had the pleasure to interact with! Can't wait to see what's next in house for you!!!!
Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@LyssiotisLab @ArulChinnaiyan), has just been published in @Nature! @UMRogelCancer @UMICHpancreas @UMichMedSchool @UMichPath @UMichResearch @UMichCMB
Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@LyssiotisLab @ArulChinnaiyan), has just been published in @Nature! @UMRogelCancer @UMICHpancreas @UMichMedSchool @UMichPath @UMichResearch @UMichCMB
A seriously awesome event (despite my tardy post)!! Thanks @NYASciences, @nyugrossman, fellow organizers (@lydfinley, @MarcusDGon), the *speakers for sharing awesome (and unpublished) science, and the attendees for literally packing the house! (Every seat reserved) 😃 *Speakers:…
Grateful for another day of outstanding science at the cancer metabolism symposium @NYASciences. Feeling lucky to see so much amazing basic and translational metabolism work over 10 years of symposia with this guy @LyssiotisLab. Here’s to the next 10 years of metabolism research!
Excited to share new report from collaborative work from @DelgoffeLab and @PatrickJonker4 from our team on a novel metabolic suppressor of T cell function in tumors! rdcu.be/eiyIa 1/
Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis dlvr.it/TKDtGb
Happy to share our most recent review on mitochondria-organelle metabolic communication with @YatrikShahLab and @LyssiotisLab!! We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals! sciencedirect.com/science/articl…