Caleb Cheng
@DJCalebC
✝️🇹🇼🇺🇸MD/PhD candidate studying pancreatic cancer in @ArulChinnaiyan and @Lyssiotislab at @UmichMedSchool
Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@LyssiotisLab @ArulChinnaiyan), has just been published in @Nature! @UMRogelCancer @UMICHpancreas @UMichMedSchool @UMichPath @UMichResearch @UMichCMB
Uridine is having a moment… we thought, worthy of the designation: Metabolite of the Month😆 @julia_ugras Jokes aside, a deluge of recent work indicates unique signaling and metabolic roles for uridine in hunger/satiety (in man), temperature, energy, and even walking (in mice)…
Happy Friday! @LyssiotisLab and I had a fun time hyping up our favorite metabolite Uridine as the Metabolite of the Month in @CellCellPress! We hope you enjoy this quick read! cell.com/trends/endocri…
Happy Friday! @LyssiotisLab and I had a fun time hyping up our favorite metabolite Uridine as the Metabolite of the Month in @CellCellPress! We hope you enjoy this quick read! cell.com/trends/endocri…
Congrats @LyssiotisLab!!
So grateful and excited to partner with the @sgpcri to advance our collaborative program targeting lysosome and Kras metabolism in pancreatic cancer! 🙏🏼 @sgpcri for their support and vision! 🙏🏼 collaborators without whom this work would not be possible! @ArulChinnaiyan,…
PIKfyve governs endoplasmic reticulum-lysosome contacts to modulate endoplasmic reticulum dynamics biorxiv.org/content/10.110… #biorxiv_cellbio
🚨 New NIH Public Access Policy goes into effect TODAY! Research accepted for publication on July 1, 2025, must be publicly available as soon as it is published. This date was moved up from December 31, 2025, to ensure radical transparency regarding the research NIH supports.…
I’m so lucky to be a part of this lab! Thanks to your leadership and guidance @LyssiotisLab
It’s been a decade - Happy 10 year Labiversary @LyssiotisLab 🎉🥳 Thank you to all have who been along on the journey 🙏🏼 @UMPhysiology, @UMRogelCancer, @UMICHpancreas
Congrats Diana!!
🎉 I’m thrilled to share my first PhD paper published recently👇! We @YatrikShahLab explored how lipid-mediated crosstalk between fibroblasts and epithelial cells drives ferroptosis in inflammatory bowel disease. Excited to keep pushing this work forward in the lab!
A study from #RogelCancer researchers @ArulChinnaiyan and @abhijitparolia, published in @ScienceMagazine, sheds light on how mutations in the FOXA1 gene—commonly altered in prostate cancer—drive tumor initiation formation and therapeutic resistance. michmed.org/XWArW
Fibroblast lipid metabolism through ACSL4 regulates epithelial sensitivity to ferroptosis in IBD go.nature.com/3TaGVMA
Man. Don’t know how to explain it other than shock. Words cannot express the pain of this letdown. The frustration is unfathomable. I’ve worked my whole life to get to this moment and this is how it ends? Makes no sense. Now that I’ve gotten surgery, I wish I could count the…
The *celebration white board* hit capacity 🙌🏼 Taking the time to enjoy and share in our victories 🤩😎 cc: @UMPhysiology, @UMRogelCancer, @UMICHpancreas
Really enjoyed using @lucidsci Resipher to measure real-time OCR as part of the study. More to come! @YatrikShahLab @LyssiotisLab
In a recent Nature paper, @DJCalebC et al. explore how PIKfyve regulates lysosomal lipid recycling in pancreatic ductal adenocarcinoma (PDAC). Loss of PIKfyve disrupts this recycling, driving tumor cells to compensate via de novo lipogenesis. This compensatory shift opens up a…
From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science go.nature.com/44hKo29
New study suggests possible treatment option for high-grade serous tubo-ovarian carcinoma with CDK12 loss. #ChinnaiyanLab Read the summary: michmed.org/28zry Read the paper in @PNASNews: doi.org/10.1073/pnas.2…
Long overdue, but super excited to have @NinaSteele17 come to @CincyMedicine to continue her lab and track record of success. Pancreatic cancer, your days are numbered. @SyedAAhmad5 @LuisLaraMD1 @uofcincycancer @krushnacpatra @GregWilson152
Happy to have contributed in a small way to this very cool study from Jim Wells lab, led by Fangzhu Zhao. They developed low-density lipoprotein receptor-targeting chimeras (LIPTACs) to promote induced extracellular protein degradation & ADC delivery. 👏 biorxiv.org/content/10.110…
My lab's first paper is out in @Nature. We show that lipoprotein uptake protects tumors from ferroptosis by delivering the lipid antioxidant α-tocopherol. Surprisingly, tumors use sulfated glycosaminoglycans—not canonical receptors—to capture lipoproteins. nature.com/articles/s4158…
Researchers at the @UMRogelCancer identified a gene that plays a key role in prostate cancer cells that have transitioned to a more aggressive, treatment-resistant form. myumi.ch/E87RN
On Tuesday, the FBI disclosed they would be charging Yunqing Jian, a Chinese student and research fellow in molecular, cellular and developmental biology at the University of Michigan, with allegedly smuggling dangerous pathogens into the United States. michigandaily.com/news/news-brie…
The Office of the Vice President for Research will award eight research faculty members from across the @UMich for their leadership and significant contributions in their fields. myumi.ch/8qJnj