Nobu Hamazaki

Now out in @ScienceMagazine we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment. science.org/doi/10.1126/sc…

Have you ever wondered how your back formed? The human embryo makes a neural tube (future spinal cord) and somites (trunk muscle/bone) from ~d20. They’re formed at the same time and place, so we used human Trunk-like Structures (hTLS) to investigate their ‘co-development’… (1/7)

NIH cuts are hitting young scientists the hardest. By David Baker. timmermanreport.com/2025/03/david-…

I’m delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases @ScienceMagazine! @ferreira_raph_ @LeopoldParts @ProfTomEllis, @geochurch @SangerInstitute science.org/doi/10.1126/sc… Lots of changes from the preprint. A🧵

I am excited that I can give a talk at Riken BDR CuSTOM organoid Symposium. I feel like I can finally share the full story of my main project about digit organoids. If you are interested, the free registration is still open until tomorrow. www2.bdr.riken.jp/joint-organoid…

Latest from the lab! I've been seeking the ultimate modulator that regulates the tempo of multiple developmental processes simultaneously, and metabolism has been an attractive candidate for such a global tempo modulator. However, I was wrong. 1/ nature.com/articles/s4146…

門外漢ながら、Seattleにいるというコネだけで#NeuroRadio…

#84 Synthetic developmental biology UWの浜崎伸彦さん(@Nobu_Hamazaki)がゲスト。 Human RA-Gastruloid論文、卵子様細胞形成論文、条件探索のコツ、ステージング問題、PI生活、今後目指す合成的発生生物学の方向性、など #NeuroRadio #神経科学 #ポッドキャスト neuroradio.tokyo/2025/01/07/84-…

#NeuroRadio 浜崎さん(@Nobu_Hamazaki)ゲスト回！転写因子群同定によるiPSからの卵子様細胞作成（ nature.com/articles/s4158…）、ヒトGastruloid作成（nature.com/articles/s4155…）等の『合成的な発生生物学』の解説、面白さ、課題、今後の方向性。創ることによる理解、がヒシヒシと感じられて新鮮でした。

Please circulate! @czi and @ss_f_official have started the Global Science Scholars program to exchange postdocs between the US and Japan. @yachielab in Osaka University is one of the host labs in Japan side. czbiohub.org/program-ssfcz-…

New work by Mia Yang's lab reports evidence of prevalent aneuploidies in human trophoblast stem cells and suggests that chromosomal instability may be a normal feature of placental development. biorxiv.org/content/10.110…

Our latest #Ichthyosporean #EvoDevo story, led by M. Olivetta @ChandniBhickta @NChiaruttini & in co. with @burnsajohn is finally out @Nature . Link⏩: nature.com/articles/s4158… Preprint⏩: biorxiv.org/content/10.110… 1/5)

Attending #ASHG24? Excited with new statistical genetics methods and analyzing data from newest functional genomics tech? Happy to chat if you are interested in joining my group @uwgenome UW in beautiful Seattle next spring or later 🙂

Our new paper is out @NatureCellBio🥳It shows how major epigenetic OFF mark, H3K27me3, is newly established at the beginning of life. This work was mainly carried out by a talented PhD student, Masahiro Matsuwaka👏 nature.com/articles/s4155… rdcu.be/dYJf Short summary↓↓

‘Writing music is similar to writing a research paper:’ BBI's Riddhiman Garge embraces 2 distinct passions brotmanbaty.org/news/promising… @uwgenome @UWMedicine @JShendure @lea_starita

News & Views article by Jesse and Alex on our RA-gastruloid model! Big thanks to @alex_schauer_ and @jvveenvliet for their insightful summary of our RA-gastruloid paper. The article also provides an overview of current stem-cell-based embryo models (SEMs) fields and future…

📢 Check out our @teamstembryo @NatureCellBio News & Views with postdoc @alex_schauer_ on the latest feat in human stem-cell-based embryo models by @Nobu_Hamazaki, @JShendure & colleagues. Full text: rdcu.be/dWw3c nature.com/articles/s4155… #gastruloids

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Congratulations to David and the @UWproteindesign! David’s definitely the most inspirational person I’ve ever worked with.

Whoa what amazing news! Congratulations to David, Demis, and John!