Sudarshan Pinglay
@sudpinglay
bigDNA/synBio/soccer/food/heavymetal
Now out in @ScienceMagazine we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment. science.org/doi/10.1126/sc…
CAGT was fun! Thanks @CarldeBoerPhD @sudpinglay and the de Boer lab for organizing! Folks from Seattle, Oregon, and other places. Great community. Arman gave a usual super talk, and Sanchit and @DSheykhkarimli won poster prizes☺️
Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases In new @arcinstitute work, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement
What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
We are hiring a person to join our team at the Seattle Hub for Synthetic Biology. Please share the word! Link to apply: alleninstitute.org/careers/jobs/?…
Want to play the Shuffle (on your favorite genome)? Watch this video from @GenomeTDCC highlighting @sudpinglay et al. recent @ScienceMagazine paper (link in comments). youtube.com/watch?v=rW8AFh…
We trained a genomic language model on all observed evolution, which we are calling Evo 2. The model achieves an unprecedented breadth in capabilities, enabling prediction and design tasks from molecular to genome scale and across all three domains of life.
I’m delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases @ScienceMagazine! @ferreira_raph_ @LeopoldParts @ProfTomEllis, @geochurch @SangerInstitute science.org/doi/10.1126/sc… Lots of changes from the preprint. A🧵