Jonas Koeppel
@JonasKoeppel
Postdoc in the Shendure & Pinglay labs @UW Trying to understand and engineer our wonderfully weird genomes 🧬
I’m delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases @ScienceMagazine! @ferreira_raph_ @LeopoldParts @ProfTomEllis, @geochurch @SangerInstitute science.org/doi/10.1126/sc… Lots of changes from the preprint. A🧵
Excited to share our work with @julie_trolle and @JefBoeke We developed a 'shotgun' method to screen millions of synthetic metabolic pathways to enable mammalian cells to grow without two essential nutrients for the first time in >500 million years! biorxiv.org/content/10.110…
We are hiring a person to join our team at the Seattle Hub for Synthetic Biology. Please share the word! Link to apply: alleninstitute.org/careers/jobs/?…
Our work on nucleic acid sensing in live human cells is out 🧬⚫️🟢! Big thanks to @AIMahas @LisaRiedmayr @geochurch ! Make sure to check out Ahmed's thread 👇
1. Happy to share our latest work @biorxivpreprint on developing SONAR (Sensing Of Nucleic acids using ASOs and Reverse-transcriptases) for sensing and responding to nucleic acids in living cells. biorxiv.org/content/10.110… 👇🧵
Structural variation in the human genome, often linked to disease, was mostly studied in natural variants or single loci. 2 new studies by @JonasKoeppel and @sudpinglay use CRISPR-based prime editing with recombinases to characterize them at scale. Check out their 🧵 for more👇
I’m delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases @ScienceMagazine! @ferreira_raph_ @LeopoldParts @ProfTomEllis, @geochurch @SangerInstitute science.org/doi/10.1126/sc… Lots of changes from the preprint. A🧵
We're hiring for 2 postdocs to work in our lab in London on the newly announced Wellcome Trust SynHG project. If you know people looking to work on big-scale ambitious science like this, please RT and share this with them. Apply by 7/20, interviews in Aug. imperial.ac.uk/jobs/search-jo…
Mikolaj is one of the most amazing scientist and caring person I’ve ever had the pleasure to work with. Not only did he teach me so much on how to do good science, he also showed me how incredibly fun it could be. Highly recommend checking out his lab!
I am excited to announce the launch of the Slabicki Lab at the Krantz Family Center for Cancer Research within the Mass General Cancer Center and the Cancer Program at the Broad Institute of MIT and Harvard! 🔗 Learn more: slabicki-lab.org
1/n Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv! biorxiv.org/content/10.110…
New #preprint from the lab! Do you want to see the invisible? So did we! When DNA genomes get broken, cells somehow find related sequences to fix the break. But how do they find it? We developed a way to look at sequence *search*, not just sequence usage. doi.org/10.1101/2025.0…
My lab at @MDAndersonNews is actively seeking motivated individuals (Postdocs, RAs, Scientists) interested in TPD, induced proximity, or small molecule drug discovery. (1/6)
Our genome-scrambling paper is out in @ScienceMagazine 🍳🧬! Huge thanks to everyone at @LeopoldParts and @geochurch labs, especially my amazing collaborator @JonasKoeppel!!!! Many additions to the preprint, so be sure to check out his thread 🧵!! science.org/doi/10.1126/sc…
I’m delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases @ScienceMagazine! @ferreira_raph_ @LeopoldParts @ProfTomEllis, @geochurch @SangerInstitute science.org/doi/10.1126/sc… Lots of changes from the preprint. A🧵
@LeopoldParts does amazing science and it would be a great environment to join!
If you’d like to work in this exciting science area, @LeopoldParts lab at the @sangerinstitute is hiring postdocs! This is all part of the new Generative and Synthetic Genomics programme with nearby @benlehner and Jussi Taipale sanger.wd103.myworkdayjobs.com/en-US/Wellcome…
Out now in @ScienceMagazine - Jonas and Raphael’s human genome Scramble paper which inadvertently also led to us making the ‘most engineered human genome ever’ (we think so - happy to hear otherwise). Check out Jonas’ thread below. ⬇️
I’m delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases @ScienceMagazine! @ferreira_raph_ @LeopoldParts @ProfTomEllis, @geochurch @SangerInstitute science.org/doi/10.1126/sc… Lots of changes from the preprint. A🧵
Since getting into genetics, I've been obsessed with structural variants (SVs). Of all classes of human genetic variation (e.g., SNPs, Indels), SVs affect the largest # of nucleotides by far. And yet, they've proven the hardest to study.
The most complex engineering of human cell lines ever has been achieved revealing that our genomes are more resilient to structural change than we once thought. 🧬 The work opens the door to studying structural variation in disease. Read more here ⤵️ bit.ly/42IeQSC