Meng-Ju Wu
@MJWu_TW
Assistant Professor @UMassChan interested in tumor metabolism/immune microenvironment in biliary cancer. Views are my own
New in @sciencemagazine! Our study reveals how mutant IDH1 inhibition activates tumor immunity by inducing dsDNA sensing. Read more: science.org/doi/10.1126/sc… #CancerResearch #Cholangiocarcinoma #IDH1 1/n
Had a great time co-organizing the 2nd annual GI Research Day @UMassChan ! Honored to invite my former mentor Dr. Nabeel Bardeesy as keynote. He gave a fantastic talk on new targets for hepatobiliary cancers. Grateful to all the attendees. Lots of interesting talks and posters!
The Ruscetti Lab had a strong showing at GI Research Day at UMass, with @ChaitanyaParik, Shreya, and Haruka presenting their GI (and non-GI) projects. All the trainees gave fabulous talks, capped off by a great Keynote address by Nabeel Bardeesy. Thanks for organizing @MJWu_TW!
A new cell line atlas of biliary tract cancers uncovers new subtypes and potential drug targets for better treatment of these deadly diseases. Learn more: broad.io/DepMap-BTCs @MGBResearchNews @targetcancer
Biliary tract cancers are aggressive and understudied. This landmark study,led by my brilliant colleague and friend @Vindhya_Vijay, profiles 63 BTC cell lines with multi-omics and CRISPR screens, revealing subtypes and vulnerabilities. Honored to contribute! @curecc @targetcancer
Now online in @CD_AACR: Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets - by @Vindhya_Vijay, Negin Karisani,@getz_lab, Nabeel Bardeesy, and colleagues doi.org/10.1158/2159-8… @MGHCancerCenter @broadinstitute
Distinct CD8+ T cell dynamics associate with response to neoadjuvant cancer immunotherapies dlvr.it/TK8ss6
From the April issue: Chronic #ViralMimicry Induction Following #p53 Loss Promotes Immune Evasion brnw.ch/21wRRjh By @CharlesIshak @SajidMarhon @DeCarvalho_Lab and colleagues @UHN @pmcancercentre @MDAndersonNews
Last weeks collection of #immunometabolism discoveries @Bims_BiomedNews biomed.news/bims-imicid/20… Plenty of interesting papers across innate & adaptive immunity inside
Retroelement-specific tissue resident T cells control tissue resilience and predisposition to inflammation papers.ssrn.com/sol3/papers.cf… @BelkaidLab @alexwellsies
A fun process to jump into a new topic. By integrating phosphorylation regulome, iMetAct can better predict metabolic preference. Stay tuned for the next step about how we can integrate this with machine learning! @Ludwig_Cancer @CancerResearch
iMetAct: An integrated systematic inference of metabolic activity for dissecting tumor metabolic preference and tumor-immune microenvironment dlvr.it/TJP2QP
We report a new role for HIF in the regulation of endogenous retroviruses! It was a big collaborative effort to explore the HIF-mediated transcription, expression, and HLA presentation of ERVs in kidney cancer and leveraging them for immunotherapy cell.com/cell/fulltext/…
We are hiring! Work in Taiwan with an NIH-scale salary! Please RT!
Our recent work on Viral mimicry escape in Ovarian Cancer is out at Cancer Discovery @CD_AACR. aacrjournals.org/cancerdiscover…
Awesome work! Can’t wait to chat more and see potential collaboration opportunities!
With great joy! I want to share with you our recent work on how Bile acid synthesis impedes tumor-specific T cell responses during liver cancer | Science thanks to all the authors and @Tcellogic @salkinstitute science.org/doi/10.1126/sc…
Another cool study!Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells: @CellCellPress cell.com/cell/fulltext/…
Ten years ago, I wrote a research proposal with a big question in mind: what role do the lncRNAs play? Now, a decade later, and with the incredible members in the @nevillesanjana lab, I'm finally starting to uncover some answers. Check our findings now published in @CellCellPress
Can’t wait to share this beautiful story from my friend @yujungche published on @Nature Are you also interested in cancer metabolism? Take a look! nature.com/articles/s4158…
I’m excited to share our latest study in @nature on this novel compound called Gliocidin, that targets glioblastoma (#GBM), the most malignant brain tumor. #drugdiscovery #cancer #cancermetabolism @GSKGradSchool @MSKCancerCenter nature.com/articles/s4158…
tidyplots Time to say goodbye to ggplot2?🫡 "a significant reduction of code complexity" vs ggplot2 cran.r-project.org/web/packages/t… @JanBroderEngler bioRxiv 2024 biorxiv.org/content/10.110…
The hallmarks of cancer immune evasion dlvr.it/TG8BBS