Hao Yin

Hao's Preprint Reading List July 17th 2025 Arterial thrombosis on a chip Autoantibody tertiary lymphoid organ atherosclerosis Flow-dependent neuronal motility Mitochondrial clonal tracing in human tissues NAD+ arterial calcification Spatial transcriptomics of myocarditis…

New insights into the #evolution of land plant traits through the study of a group of terrestrial and freshwater streptophyte algae. "A foremost finding was that the genetic underpinnings of several key traits emerged much earlier than land plants — they were present in their…

biorxiv.org/content/10.110… rAAV-miniBEND: A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modeling | bioRxiv; Our tool can be used to do gene delivery to BrainECs, which does not require miRNA. Hope this will be useful to your research!

"People’s brains aged faster during the #COVID pandemic — even the uninfected" The COVID pandemic significantly affected mental and neurological health. "Study of nearly 1,000 people showed that brain ageing was not linked to infection status, but cognitive decline was."…

New editorial in @ATHjournal highlights our latest work! Using an AI-driven method to extract aortic diameters from EHRs, we uncover sex-specific responses to antiplatelet therapy. Read more: atherosclerosis-journal.com/article/S0021-…

Amazing #2PM real-time morpho-dynamic responses of #Microglia to focal, laser-induced parenchymal or vascular injury in neonatal vs adult vs aged mouse brain Reaction speed 👉Parenchymal injury: Adult > Aged/Neonatal 👉Vascular injury: Adult/Aged > Neonatal What molecules…

🧬 high #altitude #mammals lost ~23% of their #olfactory #receptor #genes and evolved smaller #olfactory #bulbs compared to lowland species. 🌄 Convergent evolution— reduced reliance on smell in thin, cold, odor-poor air? 🔗 cell.com/current-biolog… #evolution #sense

(Mouse/Human) Mitochondria transplantation i.m. improves reperfusion #Angiogenesis of 🐭#LimbIschemia Macrophage, instead of #EndothelialCell, is the major cell type that internalizes exogenous Mitochondria (sustained by day 3 not 7) ⏫M2-like polarization in…

Check out the incredible lineup of speakers & submit your abstract before July 28th! meetings.cshl.edu/meetings.aspx?…

Please join us for an intimate Cold Spring Harbor Lab conference this fall (Sept 28 - Oct 1, 2025) on "Bioengineered Tissue Systems & Models" on Long Island, New York - with a recently extended abstract deadline of July 28, 2025.  More info: meetings.cshl.edu/meetings.aspx?…

𝟒. 𝐄𝐱𝐩𝐚𝐧𝐝𝐢𝐧𝐠 𝐭𝐡𝐞 𝐩𝐨𝐨𝐥 𝐨𝐟 𝐡𝐞𝐚𝐫𝐭𝐬 𝐟𝐨𝐫 𝐝𝐨𝐧𝐚𝐭𝐢𝐨𝐧⁣ Currently, there are three options for sourcing organs for heart transplant Donation after brain death is the most common route, where the donor’s heart is still beating But with a limited donor…

Top 5 advances in medicine this week (🧵) 𝟏. 𝟖 𝐡𝐞𝐚𝐥𝐭𝐡𝐲 𝐛𝐢𝐫𝐭𝐡𝐬 𝐟𝐫𝐨𝐦 𝐦𝐢𝐭𝐨𝐜𝐡𝐨𝐧𝐝𝐫𝐢𝐚𝐥 𝐝𝐨𝐧𝐚𝐭𝐢𝐨𝐧⁣ Women with mitochondrial disease can pass the condition to their children – because mitochondria, and the DNA it carries, are exclusively passed…

If you're curious in following up interesting-sounding, newly-published, mostly vascular-related, research with your own critical analysis, then follow Hao's feed. His time and effort provides us with a treasure trove of thought-provoking stuff.

1/ 🚨 Our new paper is online in @Nature ! As its first author, I’m enthusiastic to finally share it with you all!🎉 🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤 👉 nature.com/articles/s4158… @OxfordDPAG 🧵👇

8/ 🧵 The rearrangements in mitochondrial shape reflect a mismatch between ATP demand and electron flux causing the leak: during sleep deprivation, wake-promoting dopamine inhibits dFBNs, thus creating an electron surplus through elevated ATP concentrations.

Detailed planning of AAV9 intramuscular injection in ischemis🐭limb AAV9-IGF1⏫myogenesis in🐭#LimbIschemia, w/o impacting satellite cell self-renewal or #Angiogenesis Interesting myogenesis-angiogenesis decoupling!🤓 @TerenceRyan_PhD #JACCBTS 2023 sciencedirect.com/science/articl…

🎉 The revised version of CORNETO, our unified Python framework for knowledge-driven network inference from omics data, is published in peer reviewed form 🔗 Paper: nature.com/articles/s4225… 📖 News & Views: nature.com/articles/s4225… 💻 Code: corneto.org 🧵 Thread 👇

Many thanks to Ishan and Vishva for writing this nice "News and Views" article on our collaboration with Jie Xu's group (@gadawgs )! Breaking point: mechanical stress helps NINJ1 protein to rupture membranes nature.com/articles/d4158…

1/4 Muscle is great — but which muscle should you study? 💪 Our new paper shows that the soleus has uniquely large, irregular, and variable fibres — in both humans and mice! We quantified this using the Shape Factor Index (SFI): Method here: onlinelibrary.wiley.com/doi/full/10.10… 🧵

Our 2026 @MUSKOS_PhD course is now open for registration🤩 Copenhagen, 5-7 October 2026 Musculoskeletal tissue regeneration – mechanisms and clinical perspectives phdcourses.ku.dk/DetailKursus.a… @grith_hojfeldt @avonkeudell @BenChazaud @Dr_JZP @MogwaiBeth Faye Mourkioti Jerome feige