Matthew Loberg
@LobergMatthew
Aspiring physician-scientist training @VanderbiltMSTP💊 | Interested in personalized cancer therapy🦀 | Part-time amateur blogger📝 | Opinions mine
Excited to share this preprint on TNC, Wnt, and thyroid cancer! Thanks @LobergMatthew for helping me with this!
Tenascin-C potentiates Wnt signaling in thyroid cancer biorxiv.org/cgi/content/sh… #biorxiv_cancer
STAMP Single-Cell Transcriptomics Analysis & Multimodal Profiling through Sequencing-free, Imaging-based #SpatialOmics system CosMx Xenium Single-cell suspension cytospinned to slides 100 ~ >1M cells ⏫cell capture ⏬doublets Able to identify ultra-rare cell population…
Mapping cellular interactions from spatially resolved transcriptomics data nature.com/articles/s4159… (read free: rdcu.be/dSTC5) Spacia software: github.com/yunguan-wang/S… 🧬🖥️
Congrats @mtigue13 !! Can't wait to see where this project goes!
Congratulations @mtigue13 for the superb presentation at #PAS2025. More exciting work to come from this stellar student!
Congratulations to @LobergMatthew for the awesome poster presentation at AACR. Thanks also to our fantastic collaborative team.
Spotiphy enables single-cell spatial whole transcriptomics across an entire section | Nature Methods nature.com/articles/s4159…
We are excited to share our new work out today in @NatureCellBio uncovering a new Achilles heel of pancreatic cancer. Myc is a key driver of PDAC and predicts poor survival. Thus, we asked the question of how Myc protein levels are regulated in PDAC. 👉 rdcu.be/d8xLT 🎉
We are excited to share our recent pre-print exploring cancer-associated fibroblast (CAF) phenotypes as thyroid cancers progress from treatable well-differentiated tumors to highly lethal anaplastic thyroid cancer! @DrVivianWeiss @hartheat21 @mtigue13 biorxiv.org/content/10.110…
Thrilled to share our back-to-back two Nature @Nature papers on the unexpected role of type 2 immunity against cancer. We found that interleukin 4 (Fc–IL-4), a type 2 cytokine, reinvigorates exhausted T cells to potentiate anticancer immunotherapy w/ @YugangGUO2 @RongFan8(1/11)
New preprint from @ltkagohara @FertigLab @DrLizJaffee @wonjinho1 @AshleyKiemen @AshaniTW & colleagues @hopkinskimmel @ConvergenceInst Spatial multi-omics reveal intratumoral humoral immunity niches associated with tertiary lymphoid structures in #PancreaticCancer immunotherapy…
CellChat for systematic analysis of cell–cell communication from single-cell transcriptomics nature.com/articles/s4159…
We've been awarded an NIH R01 grant to further improve ShinyGO! 🎉 - Thank you for using it and citing our paper! - These support letters were essential! - This means the annotation databases will be updated for at least 5 years, also benefiting iDEP users. - Feel free to…
New feature for GO enrichment analysis website ShinyGO v0.741 (ge-lab.org/go/): Detailed genes info with links to NCBI and Ensembl. A fully customizable lollipop plot to visualize enrichment. Is it too fancy?
SpatialOne: end-to-end analysis of visium data at scale academic.oup.com/bioinformatics… 🧬🖥️ github.com/Sanofi-Public/…
A unified model for interpretable latent embedding of multi-sample, multi-condition single-cell data nature.com/articles/s4146…
Now out - WebAtlas pipeline for visualizing and processing integrated single cell and spatial transcriptomics data @naturemethods @bayraktar_lab @HaniffaLab @shazanfar @humancellatlas github.com/haniffalab/web… nature.com/articles/s4159…
Many #SpatialTranscriptomics tools are out there! Which performs best? Which runs fastest? A nice resource here😆👇 16 clustering methods SpatialPCA DR.SC SpaGCN BANKSY GraphST STAGATE SEDR PRECAST conST DeepST CCST BASS ADEPT SpaceFlow BayesSpace ConGI 10…
Benchmarking clustering, alignment, and integration methods for spatial transcriptomics👍 genomebiology.biomedcentral.com/articles/10.11…
🤩Excited to share our @naturemethods comment on “Unlocking the Power of Spatial Omics with AI” nature.com/articles/s4159… co-authored with Kyle Coleman and Amelia Schroeder @UPennDBEI. Big thanks to @rita_strack for inviting us to contribute.