Lukas Valihrach

🚀 Thrilled to see our study "Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia" published in @PNAS! Major credit to @DanielZucha for leading this work, and a big thanks to all collaborators and funders who made this possible 🙌🧵

Mapping trait-associated cells with spatial transcriptomics👍 nature.com/articles/s4157…

Characterizing plaque-associated #microglia (PAM) and non-plaque-associated microglia (non-PAM) in a mouse model of Alzheimer's disease; non-PAM modulate cell population expansion in response to amyloid deposition and rapidly respond to environmental cues nature.com/articles/s4159…

Intravital Multimodal Imaging of Human Cortical Organoids for Chronic Stroke Treatment in Mice biorxiv.org/content/10.110…

Shared and disease-specific pathways in frontotemporal dementia and Alzheimer’s and Parkinson’s diseases nature.com/articles/s4159…

Jensen Huang: digital biology will be “one of the biggest revolutions ever” “Where do I think the next amazing revolution is gong to come? And this is going to be flat out one of the biggest ones ever. There’s no question that digital biology is going to be it.” Jensen…

Cell-type-directed network-correcting combination therapy for Alzheimer’s disease👏👏👏 cell.com/cell/fulltext/…

Combined single-cell profiling of chromatin–transcriptome and splicing across brain cell types, regions and disease state nature.com/articles/s4158…

Towards single-cell-resolution global maps of mammalian brains🔥 nature.com/articles/s4158…

Spatial proteomics of Alzheimer’s disease-specific human microglial states nature.com/articles/s4159…

Chimeric brain models: Unlocking insights into human neural development, aging, diseases, and cell therapies: Neuron cell.com/neuron/fulltex…

A single-cell transcriptomic atlas maps cerebellar astrocyte diversity and uncovers the transcriptional code underlying their maturation trajectories⭐ biorxiv.org/content/10.110…

STimage: Robust, confident and interpretable models for predicting gene markers from cancer histopathological images biorxiv.org/content/10.110…

One Section, Two Worlds: Single-Cell Integration of MALDI-MSI and Spatial Transcriptomics on the Same Single Tissue Section biorxiv.org/content/10.110…

Single-Cell and Spatial Profiling of Tumor Microenvironment Heterogeneity in Human Osteosarcomas biorxiv.org/content/10.110…

Adult organotypic brain slice cultures recapitulate extracellular matrix remodelling in haemorrhagic stroke biorxiv.org/content/10.110…

MerQuaCo: a computational tool for quality control in image-based spatial transcriptomics👌 biorxiv.org/content/10.110…

Systematic cross-study assessment of RNA-Seq experimental workflows for plasma cell-free transcriptome profiling🧬 biorxiv.org/content/10.110…

Souporcell3: Robust Demultiplexing for High-Donor Single-Cell RNA-seq Datasets👌 biorxiv.org/content/10.110…

My postdoc work at @TreutleinLab @GrayCampLab with @JasperJanssens7 is out in @ScienceMagazine! We screen for neuron subtypes using pro-neural TFs + morphogen combinations + scRNA-seq and profiled over 700,000 cells in 480 conditions. science.org/doi/10.1126/sc…

STHELAR, a multi-tissue dataset linking spatial transcriptomics and histology for cell type annotation biorxiv.org/content/10.110…