Juan Alvarez
@JuanAlvarezDom
Assistant Professor @PennCDB @IRM_UPenn @PennIDOM @chronosleepinst, asking How circadian rhythms shape islet development and diabetes
What if the AI could write the paper for you? 🚨Spoiler alert: it does! We've designed a spatial transcriptomics AI agent to chart hPSC-pancreas maturation in vivo, and report on interesting biology, autonomously biorxiv.org/content/10.110…
Andrew @_AndrewLeduc talked about measuring protein synthesis and degradation rates in single cells at @SCP_meeting: youtu.be/adkY6txDyqs?si… We are working on writing up these results soon, and will be happy to share the data with you.
What qualities do you need to be a successful scientist? 2018 medicine laureate Tasuku Honjo shares what he believes are the "three c's": curiosity, courage and challenge. #NobelPrize
Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔 🚨In new work out today in @NatMetabolism, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s4225… 1/n
Science and innovation drive every breakthrough. On 7/21, honor Apollo 11’s legacy and tell Congress NO to research‑funding cuts. Speak up ➡️ ProtectScienceAndInnovation.org #ProtectScience #InnovationMakesAmericaGreat
Predicting spatial patterns from expression profiling alone, congrats @arjunrajlab !
Very excited to share our new work on gastruloids by the incredible @ugcgccacc! We mapped gene expression across 26 individual gastruloids at single-cell resolution and discovered some pretty amazing patterns about how these "mini-embryos" organize themselves.
Very excited to share our new work on gastruloids by the incredible @ugcgccacc! We mapped gene expression across 26 individual gastruloids at single-cell resolution and discovered some pretty amazing patterns about how these "mini-embryos" organize themselves.
Today @ 1pm EST - spatial transcriptomics AI agent for the non-CS expert, looking forward!
Democratizing Spatial Tx-omics webinar, with @ganoopyliujia @WangXiaoLab's @wenbowang11 @ZuwanLin - Looking forward this July 17!
Democratizing Spatial Tx-omics webinar, with @ganoopyliujia @WangXiaoLab's @wenbowang11 @ZuwanLin - Looking forward this July 17!
Hey everyone! Come join me in Mexico to hear about retrotransposons like Endogenous Retro Viruses that have switched sides and now help their hosts!
@TheModzLab we are looking forward to your presentation at #EREHD25 in Mexico this November🧬 Please share with your followers to let them know our early bird & talk submission deadline has been extended, so submit & register today! 🔗bit.ly/4kNH98y
Our latest work is on the cover of @Nature (June 26, 2025)! Even more special: the stunning illustration was hand-drawn by first author Hao Sheng — a true scientist-artist.
Happy to share the exciting news that Jeya’s paper on ChemPerturb-Seq is online @JeyaVandana @TPCB_NYC @WCMSurgery @WCMCGH @WeillCornellGS cell.com/cell-stem-cell… We’ve also developed an AI-powered, open-access website. Have fun. chemperturbdb.com
Big #T1D news! Vertex has published their phase 1–2 trial of stem cell-derived islets (VX880, now called zimislecel). All 12 full-dose patients had reduced insulin need, and 10 no longer require insulin injections. Major step forward to a functional cure! nejm.org/doi/full/10.10…
Ives et al. applied top-down proteomics to evaluate proteoforms from human islets treated with cytokines. They identified several proteoforms that may be useful in determining the onset of T1D or candidate targets for therapeutic intervention. biorxiv.org/content/10.110…
Swensen et al. aimed to identify in situ proteome alterations of the human islets during stage 1 #type1diabetes through proteomics profiling of human islets by laser microdissection of islet sections taken from AAb+ and age- and sex-matched control donors. link.springer.com/article/10.100…
This is a very good review on ~12h biological rhythms. Biological rhythms: Living your life, one half-day at a time | npj Biological Timing and Sleep nature.com/articles/s4432…
Good things come in two's: celebrating couple graduates, grants, preprints.. Couldn't have imagined a better team of mavericks!
The @BreakthroughT1D Barbara Dewey Cammett Center of Excellence, led by Dr. David Harlan, consists of scientists from @UMassChan, @jacksonlab, @harvardmed & @UofT who are collaborating to develop a T1D cell replacement therapy to evade the immune system. bit.ly/450wMcC
Don't miss the last talk of the year! Yuval Dor on RNA editing
Listen to @davidrliu explain why it is so important to support basic science
I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with @WalterIsaacson & @amanpour on @AmanpourCoPBS, airing on @PBS tonight at 11 pm ET, and on @cnni earlier today. Pls share! youtube.com/watch?v=8YhJM6…
Tissue-specific loss of #Tregs and rise of stem-like CD8+ T cells prior to the onset of #TypeIDiabetes may offer promising window for early intervention doi.org/10.1038/s41467… @BettsLab #Diabetes #T1D #ImmunePhenotype #Autoimmunity #TranslationalScience