Bokai Zhu lab

A very nice perspective on ultradian rhythms!

This is a great lab!!

Left by the tides | Pitt Med Magazine | University of Pittsburgh. A nice piece on our earlier work on identifying 12h rhythms in ‘free-living” humans. pittmed.pitt.edu/news/12-hour-b…

This is a very good review on ~12h biological rhythms. Biological rhythms: Living your life, one half-day at a time | npj Biological Timing and Sleep nature.com/articles/s4432…

Interesting work. 12h rhythms of lipid metabolism in the Drosophila fat body, independent of the circadian clock. Circadian clock-independent ultradian rhythms in lipid metabolism in the Drosophila fat body - Journal of Biological Chemistry jbc.org/article/S0021-…

This is like AlphaFold, but for protein localisation rather than folding It's a deep learning model that predicts a protein's subcellular compartment based on its amino acid sequence alone:

The Aging Institute is pleased to share the most recent edition of our newsletter, The Chronos Chronicle, Winter 2025. Read more about the exciting research happening at the Aging Institute here: aging.pitt.edu/newsletter-win…

Fascinating work! Circatidal control of gene expression in the deep-sea hot vent shrimp Rimicaris leurokolos | Proceedings of the Royal Society B: Biological Sciences royalsocietypublishing.org/doi/10.1098/rs…

Twelve-hour ultradian rhythmic reprogramming of gene expression in the human ovary during aging | Journal of Assisted Reproduction and Genetics link.springer.com/article/10.100…

🚨Pre-print Alert!🚨 THRILLED to share our new story with MANY unexpected turns, leading us into territories entirely new to the lab! *A mitochondrial redox switch licences the onset of morphogenesis in animals* A detailed🧵on it will follow soon!! biorxiv.org/content/10.110…

The 2024 Nobel Prize in Literature has been awarded to ChatGPT for democratizing the creative process and freeing the written word from humanity’s limitations.

🦕Welcome to the Jurassic era of STING! Online @MolecularCell We uncovered a primordial role of the cGAS-STING pathway in lysosomal biogenesis & stress clearance, revealing its ancient function predating type I interferons. authors.elsevier.com/a/1joCM3vVUPRm… Kudos to Bo Lv & coauthors!! 1/n

📰New study in @MolecularCell from @AgingPitt researchers including @JayXiaojunTan and @LabZhu suggest STING may play a major role in aging. Read more: inside.upmc.com/double-edged-s…

Epigenetic regulation of global proteostasis dynamics by RBBP5 ensures mammalian organismal health biorxiv.org/content/10.110…

Achieving optical transparency in live animals with absorbing molecules | Science science.org/doi/10.1126/sc…

We received 265 attendees per lecture in the summer seminar series. Now, we have finalized the speaker list and presentation dates for this upcoming fall seminar series. We continue to look forward to exciting science and inspiring discussions.

Our aging paper just came out. Two periods of major changes: Mid 40s and 60s. Check it out doi.org/10.1038/s43587…

We are exciting to share our most recent study where we discovered ~12h rhythms of mRNA processing and proteostasis gene expression in the white blood cells of healthy humans under ‘free-living’ condition, sharing great homology to circatidal gene program. nature.com/articles/s4432…

Let's talk about Healthy Aging. So much to do in this growing field. AGE has been on my mind lately, since we are almost at the end of my birthday month! @NIHAging @BuckInstitute @scifri @Radiolab