Jason Lee
@JLeeLab
Assistant Professor @BCMhouston studying the logistics of subcellular organization. Membrane-bound and membrane-less organelle functions and contacts.
1/A picture is worth a thousand words but what if they can say more?! We developed live-cell FLIM approaches to track protein interactions within RNA-protein condensates – Our first paper is now out in @JCellBiol! doi.org/10.1083/jcb.20…
How does the cBAF complex use disordered protein to engage diverse transcriptional regulators like YAP1, SOX2, and CBP/p300? San’s tweetorial and new Mol Cell paper reveal β-catenin’s role as a molecular adapter
Excited to share our new Molecular Cell paper! We show that β-catenin is an adaptor that links canonical BAF (cBAF) with binding partners via IDR-domain interactions. (1/7) cell.com/molecular-cell…
If only one part of this interview was seen by everyone, I would hope it is this part:
My lab’s 5-year NIH R01 grant, awarded to study gene therapy for hearing loss, was abruptly terminated. I want to share how this action has been incredibly harmful and disruptive, not just to my lab, but to the scientific process itself. 1/15
Online Now! Hallmarks of stem cell aging dlvr.it/TLXcsM #stemcells
My two NIH cancer research grants were terminated today. One involving breast cancer prevention is an “outstanding investigator award” and had received a perfect score by reviewers. How does ending lifesaving cancer research make Americans healthier? @harvardmed @aacr
ICYMI: Congratulate Dr. M Goodell @Goodell_Lab for being elected to @theNASciences! @bcmhouston @BCMCancerCenter blogs.bcm.edu/2025/05/13/fro…
New preprint from the lab! With @Brumbaugh_JB, we show that P-bodies sequester developmentally relevant RNAs to influence cell fate. miRNAs direct this conserved regulatory process, and manipulating it enhances totipotency and germ cell programming. biorxiv.org/content/10.110…
New preprint countdown! Mitochondria are cells within our cells. They need the same core activities - replication, transcription, translation. How do cells enable these diverse activities in both compartments? We uncover an unexpected strategy with ancient origins. Stay tuned!
Delighted to share my PhD thesis work is now published in @Nature! This study tracks the journey of blood stem cells in aging mice, examining how the clonal dynamics of blood production change over time. A short 🧵1/n #aging #stemcells #clonalhematopoiesis nature.com/articles/s4158…
In lab's #FIRSTPREPRINT, we present methods to measure nanometer organization around & between specific proteins in condensates. We uncover unexpected heterogeneity for a liquid-like phase with local meshwork spanning 10-50nm, stemming from ribosome biogenesis in the nucleolus.
Nanometer condensate organization in live cells derived from partitioning measurements biorxiv.org/content/10.110… #biorxiv_biophys
🚨 New preprint! 🚨 Wnt/Ror2 signaling stabilizes basal identity. Using lineage tracing, we show that Ror2 loss disrupts mechanotransduction (RhoA-ROCK1-YAP1) & chromatin accessibility, driving a basal-to-luminal transition in the mammary gland. 🔗:biorxiv.org/content/10.110…
In vitro reconstitution of minimal human centrosomes biorxiv.org/content/10.110… #biorxiv_cellbio
MD Anderson and @TexasChildrens announce a transformational collaboration dedicated solely to pediatric cancer care. This new first-of-its-kind joint venture, which will launch in early 2026, has a single mission: to end #ChildhoodCancer. Learn more: bit.ly/3X9VtOR…
Some good news (and fresh science) to break things up! Our work identifying a subpopulation of compositionally unique mitochondria that localize to filopodia and promote cell migration is now online @CurrentBiology! Led by fantastic @madeleinemarlar! cell.com/current-biolog…
1/ Pleased to share our review, published today @NatRevImmunol, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. nature.com/articles/s4157…
Against all odds, we scraped together a ☃️. A magical day in Houston!
For aspiring researchers #asbmbMOSAIC scholar Diego Pedroza has just one piece of advice: “Do not just do one thing ... Explore different fields. Do chemistry, do physics, cell biology, molecular biology … Eventually, you’ll find the one thing you love.” ow.ly/Vo8550UIT6X
Identification of a factor that accelerates substrate release from the signal recognition particle | Science science.org/doi/10.1126/sc…
Sunrise, long lines and menudo before a 10am chalk talk @bcmhouston
