Jonathan Friedman
@LabFriedman
Assistant Professor in Cell Biology at UTSW, studying how organelles are shaped and organized
Some good news (and fresh science) to break things up! Our work identifying a subpopulation of compositionally unique mitochondria that localize to filopodia and promote cell migration is now online @CurrentBiology! Led by fantastic @madeleinemarlar! cell.com/current-biolog…
Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @WashUBBSB graduate student Youmian Yan. A 🧵 biorxiv.org/content/10.110…
Important to celebrate trainee victories: excited to have @HollyMerta's paper out in @CellReports. We use TurboID sub-organelle proteomics to map the ER network. We discover calmin/CLMN, an ER-to-actin tether regulating focal adhesions & cell motility. sciencedirect.com/science/articl…
If you are on UTSW campus May 16, please join us for the Lipid Metabolism & Neurodegenerative Disease mini-symposium! Many thanks to keynote speaker Dr. Hugo Bellen.
Don’t miss out on the Lipid Metabolism and Neurodegenerative Diseases 2025 Mini Symposium! Check out the agenda below for the full details ⬇️
Reminder to join us tomorrow at 12pm ET
Be sure to mark your calendars for March 26th at 12pm ET for the @AsbmbLrd seminar series. We have two great mitochondria-focused lipid talks planned from @JasonCasler1 from Laura Lackner's lab and Kailash Venkatraman from @ibudin's lab. Register here! events.zoom.us/ev/AqPwG5k03Rl…
Be sure to mark your calendars for March 26th at 12pm ET for the @AsbmbLrd seminar series. We have two great mitochondria-focused lipid talks planned from @JasonCasler1 from Laura Lackner's lab and Kailash Venkatraman from @ibudin's lab. Register here! events.zoom.us/ev/AqPwG5k03Rl…
For #teamtomo, context is everything. We highlight the power of #surfacemorphometrics in guiding STA and quantitatively assessing the impact of these structures on the local environment. @benjaminbarad
Ya-Ting Chang, @nani_grotjahn et al. @scrippsresearch present a membrane-guided approach for identifying a subset of cytoplasmic #ribosomes oriented for protein import on the surface of #mitochondria in budding yeast using #cryoET hubs.la/Q039KqS80
Happy to announce I am serving as Director of the Lipid Metabolism & Neurodegenerative Diseases (LMND) Program at UTSW. Our goal is to stimulate collaborations bridging lipid metabolism & neurological disease. So proud of our lab & their cell biology adventures! #onward_science
Edington et al. @labfriedman @UTSWMedCenter identify a mitochondrial inner membrane protein that marks and facilitates a subset of sites of mitochondrial fission in human cells. hubs.la/Q030B0yQ0 #Organelles #Mitochondria
Looking for some holiday reading material? Our latest paper identifying a new player in mitochondrial fission is now out @JCellBiol! A wonderful early present to see this now online! rupress.org/jcb/article/22…
As you're planning out your ASCB schedule be sure to attend the organelle-focused special interest group hosted by @nieminm and myself Mon. 12/16 at 5pm
Honored and excited to present some of our latest work as part of this session!
Join JCB Session 🗓️ Sat. December 14 11:15am at #CellBio2024! @s__ellis, @LabFriedman, @Meng2Fu, @BinyamMogessie, & Andrew Muroyama will discuss how new techniques in cell biology are revealing insights into how cells function across different scales. 👉 hubs.la/Q02Z5M2Q0
Be sure to check out @MitOtalks Thursday (10am US central time) for a double feature, including our amazing student Alia @TheMitotracker who will be presenting her work identifying a new player in mitochondrial fission! You can find a zoom link at mitotalks.org
Interested in BNIP3/NIX-mediated mitophagy? Check out our new review, written with @LabFriedman, about recent advances in the field and our thoughts on the regulation of these mitophagy receptors in space and time. doi.org/10.1042/BST202…
Seen a flurry of papers about BNIP and NIX and mitophagy the last few years and want to learn more? Check out this new review that @nieminm and I wrote to put them in context. portlandpress.com/biochemsoctran…
Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria! biorxiv.org/content/10.110…
🚨 New paper alert from @martenssascha!🚨 We explore how transmembrane cargo receptors initiate selective autophagy. Through biochemical reconstitutions, we discover a new autophagosome biogenesis pathway with implications for therapeutic interventions. biorxiv.org/content/10.110…
🚨The ECSO Lab at Purdue is looking for *two* PhD students and *one* postdoctoral researcher for the projects *“The energetic costs of new genes and cellular complexity”* and *“The physiology and metabolism of common and rare photosymbiotic associations.”* Please share 🙏
Really excited to share our latest paper describing the MitoLuc assay for quantitative mitochondrial protein import, which we wrote in collaboration with @IanofBristol! sciencedirect.com/science/articl…