Cell Stem Cell

@CellStemCell

A monthly journal at the forefront of stem cell science and policy. Posts & opinions from Editor-in-Chief, Dr. Sheila Chari

Cambridge, MA

Joined June 2009

69Following

58KFollowers

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Cell Stem Cell@CellStemCell · 8 h

Interested in sharing your research at our Cell Symposium in LA? We're keeping the abstract submission system open for poster and short talk submissions until August 1, 2025. Submit here: hubs.li/Q03yrNNL0 @CellSymposia #CSStemCells25

CellStemCell's tweet image. Interested in sharing your research at our Cell Symposium in LA?
We're keeping the abstract submission system open for poster and short talk submissions until August 1, 2025. Submit here: hubs.li/Q03yrNNL0 @CellSymposia #CSStemCells25

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Cell Stem Cell@CellStemCell · Jul 4

An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier dlvr.it/TLkmhX

CellStemCell's tweet card. Lall et al. differentiate iPSCs from young-onset, sporadic ALS patients into spinal cord motor neurons and co-culture them with brain microvascular endothelial-like cells in a microfluidic organ-chip...

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Cell Stem Cell@CellStemCell · Jul 17

Online Now! Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity dlvr.it/TLz2yR #stemcells

CellStemCell's tweet card. Challen and colleagues show that the clonal expansion of Dnmt3a-null HSCs in serial bone marrow transplantation assays is not dependent on the loss of DNA methylation functions of Dnmt3a. They...

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Cell Stem Cell@CellStemCell · Jul 17

Final call: Abstracts for Gene and cell-based therapies are due tomorrow Friday, July 18. Submit now for a chance to present your work at this symposium in LA! @CellSymposia #CSStemCells2025 hubs.li/Q03xfzVw0

CellStemCell's tweet image. Final call: Abstracts for Gene and cell-based therapies are due tomorrow Friday, July 18. Submit now for a chance to present your work at this symposium in LA! @CellSymposia #CSStemCells2025
hubs.li/Q03xfzVw0

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Cell Stem Cell@CellStemCell · Jul 15

Explore cutting-edge @CellStemCell research: hubs.li/Q03xdKVw0 Cell Stem Cell papers are available for full download 12 months after publication

CellStemCell's tweet image. Explore cutting-edge @CellStemCell research: hubs.li/Q03xdKVw0
Cell Stem Cell papers are available for full download 12 months after publication

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Cell Stem Cell@CellStemCell · Jul 15

Looking forward to hearing from @Thomas_Rando @UCLAstemcell, Gordana-Vunjak-Novakovic @GVNlab @Columbia & Juan Carlos Izpisua Belmonte @altos_labs in our session “Aging and rejuvenation” @CellSymposia #CSStemCells2025. Abstracts due: July 18! hubs.li/Q03xf9GD0

CellStemCell's tweet image. Looking forward to hearing from @Thomas_Rando @UCLAstemcell, Gordana-Vunjak-Novakovic @GVNlab @Columbia &amp; Juan Carlos Izpisua Belmonte @altos_labs in our session “Aging and rejuvenation” @CellSymposia #CSStemCells2025. Abstracts due: July 18!
hubs.li/Q03xf9GD0

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Cell Stem Cell@CellStemCell · Jul 14

Explore a collection of articles highlighting recent advancements in gene editing, viral vector delivery, and bioengineering techniques that are accelerating the development of gene and cell-based therapies hubs.li/Q03x01Zw0

CellStemCell's tweet image. Explore a collection of articles highlighting recent advancements in gene editing, viral vector delivery, and bioengineering techniques that are accelerating the development of gene and cell-based therapies
hubs.li/Q03x01Zw0

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Cell Stem Cell@CellStemCell · Jul 11

Online Now! Bacterial ADP-heptose triggers stem cell regeneration in the intestinal epithelium following injury dlvr.it/TLsYzs #stemcells

CellStemCell's tweet card. Here, Goyal et al. identify that the ALPK1-TIFA innate immune signaling pathway regulates regeneration in the intestinal epithelium. Importantly, detection of ADP-heptose by ALPK1 triggers intestinal...

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Cell Stem Cell@CellStemCell · Jul 7

Toward building kidney organoids with plumbing: Fusion of nephron with ureteric bud dlvr.it/TLnLH1

CellStemCell's tweet card. The fusion of distal nephron and ureteric bud represents a critical developmental milestone required for establishing a functional kidney plumbing system. In this issue of Cell Stem Cell, Shi et al....

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Cell Stem Cell@CellStemCell · Jul 7

The future belongs to those who believe in multiplex CAR T engineering dlvr.it/TLn8hn

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Cell Stem Cell@CellStemCell · Jul 7

We’ve extended the abstract deadline for @CellSymposia #CSStemCells2025 unitl July 18 to allow participants more time to complete their submissions. Submit your abstract for a chance to present your research at this exciting event in LA! hubs.ly/Q03v_rmJ0

CellStemCell's tweet image. We’ve extended the abstract deadline for @CellSymposia #CSStemCells2025 unitl July 18 to allow participants more time to complete their submissions. Submit your abstract for a chance to present your research at this exciting event in LA!
hubs.ly/Q03v_rmJ0

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Cell Stem Cell@CellStemCell · Jul 4

Beyond transplantation: Gene-edited pig liver supports function in a human host dlvr.it/TLl43M

CellStemCell's tweet card. A recent study in Nature demonstrates that a gene-edited pig liver can function in a brain-dead human for short-term support. This highlights the potential of xenogeneic liver transplantation as...

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Cell Stem Cell@CellStemCell · Jul 4

From symbiote to bad neighbor: The intestinal microbiome as a driver of CHIP dlvr.it/TLkzxd

CellStemCell's tweet card. Hematopoietic stem cells (HSCs) with mutations that can cause clonal hematopoiesis of indeterminate potential (CHIP) accumulate during aging. Agarwal et al. demonstrate in Nature that intestinal...

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Cell Stem Cell@CellStemCell · Jul 4

Hallmarks of stem cell aging dlvr.it/TLkx8d

CellStemCell's tweet card. Aging disrupts core functions of somatic stem cells throughout the body, leading to impaired tissue maintenance and repair. We identify five key features of aged stem cells, highlighting how their...

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Cell Stem Cell@CellStemCell · Jul 3

To play Paneth or goblet: Shapeshifting secretory cells read the room dlvr.it/TLk21r

CellStemCell's tweet card. (Cell Stem Cell 32, 861–863; June 5, 2025)

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Cell Stem Cell@CellStemCell · Jul 3

Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength dlvr.it/TLjzRW

CellStemCell's tweet card. Wang et al. uncover that aged muscle stem cells have blunted PGE2-EP4 signaling that is critical for their regenerative function. Treatment with exogenous PGE2 reverses age-related defects in muscle...

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Cell Stem Cell@CellStemCell · Jul 3

Human airway submucosal gland organoids to study respiratory inflammation and infection dlvr.it/TLjwwt

CellStemCell's tweet card. Lin and Pou Casellas et al. established human airway submucosal gland (SMG) organoid cultures that capture region-specific mucous cells and viral infection responses. These SMG organoids provide a...

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Cell Stem Cell@CellStemCell · Jul 3

Preferential tumor targeting of HER2 by iPSC-derived CAR T cells engineered to overcome multiple barriers to solid tumor efficacy dlvr.it/TLjvF9

CellStemCell's tweet card. Hosking and colleagues have generated and preclinically characterized an off-the-shelf, allogeneic CAR T cell, derived from an induced pluripotent stem cell, that is intended to target HER2 on cancer...

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Cell Stem Cell@CellStemCell · Jul 3

IGF2BP1 restricts the induction of human primordial germ cell fate in an m6A-dependent manner dlvr.it/TLjs9K

CellStemCell's tweet card. Zhang, Gu, Tong, et al. use human primordial germ cell-like cells induced from ESCs to show that germline entry is restricted via epitranscriptomic regulation of OTX2 by the m6A reader IGF2BP1. They...

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Cell Stem Cell@CellStemCell · Jul 3

Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia dlvr.it/TLjnsM

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