Ioannis Mantas

I am pleased to share our publication on the crucial role of Nurr1 in modulating the response to hallucinogens in the claustrum. A huge thank you to @perlmannlab, @giacomello_lab, @CarlenLab and @Boehringer #Claustrum #Nurr1 #Hallucinations nature.com/articles/s4146…

Excited to share our latest manuscript from my previous lab, exploring the neuroanatomical and molecular mechanisms underlying atypical antipsychotics! #p11 , #antipsychotics , #serotonin ,#fUS . nature.com/articles/s4138…

Enduring modulation of dorsal raphe nuclei regulates (R,S)-ketamine-mediated resilient stress-coping behavior nature.com/articles/s4138…

We found that endogenous ligand for GPR139 is opioid peptide dynorphin. With this, GPR139 may not be an orphan any more but the 5th opioid receptor. Heavy lift by talented Xiaona Li with great thanks to all who contributed! nature.com/articles/s4146…

New in Current Biology "Presynaptic and postsynaptic determinants of claustro-cortical connectivity" CLA→ACC projections are highly specific: defined by presynaptic identity, postsynaptic target, and cortical layer. Check it here: sciencedirect.com/science/articl… #Neuroscience #Claustrum

Parkinson's disease-vulnerable and -resilient dopamine neurons display opposite responses to excitatory input biorxiv.org/content/10.110… #biorxiv_neursci

Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations nature.com/articles/s4146…

Allosteric modulators of D2 - we're coming for you! Read our latest paper on where allosteric modulators of the D2 dopamine receptors bind - new strategy for treating Parkinson's disease? pubs.acs.org/doi/10.1021/ac…

Finally out! We used a translational approach to reveal a conserved role of the superior colliculus–ventral tegmental area pathway in social orienting deficits across species. ⁦@SchaerMarie⁩ ⁦@AContestabile⁩ ⁦@nadakojovic⁩ nature.com/articles/s4138…

Molecularly distinct striatonigral neuron subtypes differentially regulate locomotion nature.com/articles/s4146…

Yuuge paper on #psychedelics The structural diversity of psychedelic drug actions revealed nature.com/articles/s4146…

New research from @YanfengNeuro @StephCragg & colleagues finds that striatal cholinergic interneurons can transiently limit the reactivation of dopamine axons (via nicotinic receptors) for subsequent action potentials in dopamine neurons nature.com/articles/s4159…

I'm thrilled to share that my work is now officially available on bioRxiv! biorxiv.org/cgi/content/sh… A sincere and heartfelt thank you to our incredible team, mentors, collaborators, and funders for their unwavering support and invaluable contributions throughout this journey!

Excited to share our new study! We identify Anxa1 neurons as particularly vulnerable in Parkinson’s disease. We also show their crucial role in prodromal-phase bradykinesia and procedural motor learning.

Science Advances Dynamic responses of striatal cholinergic interneurons control behavioral flexibility science.org/doi/10.1126/sc…

Interested in dopamine regulation? Don’t forget the astrocytes! We’re excited to share our new preprint on astrocyte-dopamine interactions in the dorsal striatum and behavioral state transitions. @biorxiv_neursci, @mcgovernmit, @AnnMGraybiel biorxiv.org/content/10.110…

Thrilled to announce that our study is finally published in @CellReports! Huge thanks to our dedicated team, collaborators, reviewers, and the support from @Vetenskapsradet, @Wstiftelserna, and @StratNeuro. Proud moment! 🎉 cell.com/cell-reports/f…

Nature Neuroscience Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM–REM sleep cycle nature.com/articles/s4159…

Nature Opponent control of reinforcement by striatal dopamine and serotonin nature.com/articles/s4158…

Our new study is out! biorxiv.org/content/10.110… We (@CarlenLab) mapped the mouse PFC using single-unit activity! We recorded ~23,000 neurons across cortical/subcortical regions and profiled spont. firing patterns to reveal what separates the PFC from other brain regions. 1/n

“Whole-Brain Spatial Transcriptional Analysis at Cellular Resolution” by Per Uhlén et al. Science dx.doi.org/10.1126/scienc…