CarlssonLab (@CarlssonLab)

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CarlssonLab@CarlssonLab · Feb 24

Thanks for highlighting our paper! nature.com/articles/s4146…

PPractical_Fragments@PracticalFrag · Feb 24

Efficient search of vast chemical space: Multimillion fragment docking screen yields submicromolar OGG1 inhibitor after just a few dozen synthesized molecules practicalfragments.blogspot.com/2025/02/fragme… @CarlssonLab @NatureComms

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Tore Bengtsson@ProfBengtsson · Jul 17

Our recent work was highlighted in @NatRevDrugDisc ! Read more at: nature.com/articles/d4157…

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CarlssonLab@CarlssonLab · Jul 8

Just published in PNAS: Our structure-based virtual screening approach to identify allosteric modulators of G protein-coupled receptors (GPCRs): pnas.org/doi/10.1073/pn…. Great collaboration between @MonashUni and @uppsalauni.

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CarlssonLab@CarlssonLab · Jun 26

Biased adrenergic agonists – a novel treatment for diabetes! Amazing paper in Cell from a project led by @ProfBengtsson (Stockholm Uni) and Shane Wright (Karolinska Inst): cell.com/cell/fulltext/… Great work by my student Nour Kahlous, who performed simulations of the compounds.

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CarlssonLab@CarlssonLab · Jun 5

Lab BBQ, including chicken feet and Bánh mì.

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CarlssonLab@CarlssonLab · May 19

Article: Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D2 Receptor #research supported by Knut and Alice Wallenberg Foundation #KAW100 #Parkinsons #Dopamine @CarlssonLab @ACSPublications tinyurl.com/ycxdkcum

CCarlssonLab@CarlssonLab · May 17

Allosteric modulators of D2 - we're coming for you! Read our latest paper on where allosteric modulators of the D2 dopamine receptors bind - new strategy for treating Parkinson's disease? pubs.acs.org/doi/10.1021/ac…

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CarlssonLab@CarlssonLab · May 17

Allosteric modulators of D2 - we're coming for you! Read our latest paper on where allosteric modulators of the D2 dopamine receptors bind - new strategy for treating Parkinson's disease? pubs.acs.org/doi/10.1021/ac…

CarlssonLab's tweet card. Recently, the first small-molecule positive allosteric modulators (PAMs) of the dopamine D2 receptor (D2R) were identified. The more potent PAM potentiated the effects of D2R signaling in vitro and...

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Patrick Bryant@Patrick18287926 · May 5

AI meets rapid antiviral design. We used EvoBind to design a cyclic peptide HIV-1 inhibitor in a single shot to a novel interface, directly from sequence. Low micromolar activity, no toxicity, no structural data needed. biorxiv.org/content/10.110…

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CarlssonLab@CarlssonLab · Mar 25

Sign up for the GPCR workshop at AstraZeneca (Gothenburg), 6th of May! Please share this information! Sign up here: insingulo.com/registration

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Nathan Poongavanam@vasanthanathan · Mar 20

Glad to share our new article on the #hydrophobic #collapse of #PROTACs ! pubs.acs.org/doi/10.1021/ac…

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CarlssonLab@CarlssonLab · Mar 19

scilifelab.se/news/supercomp…

CarlssonLab's tweet card. Two new studies from SciLifeLab researchers showcase different strategies on how supercomputers can rapidly identify new drug candidates. One of the biggest challenges in any drug discovery campaign...

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Andreas Luttens@luttens · Mar 16

In our latest paper we share our machine learning protocol to screen billions of compounds for novel ligands with tailored properties. @scilifelab, @UU_University, @UniversidadeUSC, @KAWstiftelsen nature.com/articles/s4358…

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CarlssonLab@CarlssonLab · Mar 14

Wow,wow,wow!!

CCarlssonLab@CarlssonLab · Mar 13

Identifying ligands for therapeutic targets among billions of compounds is challenging! Can we search ultra-large chemical libraries more efficiently? Yes! Read about our docking/ML approach: nature.com/articles/s4358…

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Nature Computational Science@NatComputSci · Mar 13

📢@luttens, @CarlssonLab and colleagues develop an efficient method to screen libraries containing billions of compounds. @UU_University, @scilifelab, @Cancerfonden, @Vetenskapsradet, @KAWstiftelsen, @ERC_Research, @EnamineLtd, @broadinstitute, @MIT_IMES nature.com/articles/s4358…

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CarlssonLab@CarlssonLab · Mar 13

Identifying ligands for therapeutic targets among billions of compounds is challenging! Can we search ultra-large chemical libraries more efficiently? Yes! Read about our docking/ML approach: nature.com/articles/s4358…

CarlssonLab's tweet card. Nature Computational Science - Combining conformal prediction machine learning with molecular docking, a method to efficiently screen multi-billion-scale libraries is developed, enabling the...

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David Gloriam@David_Gloriam · Mar 3

Curious about the new trends in #GPCR #drug discover? See our new analysis review out today in Nature Reviews Drug Discovery. doi.org/10.1038/s415... 36% (n=516) of all approved drugs act on 121 GPCRs targets.

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CarlssonLab@CarlssonLab · Feb 26

mynewsdesk.com/uu/pressreleas…

CarlssonLab's tweet card. A recent study shows that computer algorithms can be used to find molecules that can be developed into anti-inflammatory drugs. In the article, the...

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Matthew Eddy@MatthewEddyLab · Feb 21

The cover featuring our recent fragment binding study is now out @ ACS Chem Bio: pubs.acs.org/toc/acbcct/20/… Huge thanks to the talented Ivo Kabelka from @CarlssonLab for creating this beautiful cover art.

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