Kirill Martemyanov Lab
@KLabGPCR
GPCRs in neural circuit function
We have innovated design of templates for CRISPR/Cas9 editing which allows efficient introduction of epitope tags in vivo. It is a simple hack which we hope to be broadly useful. Work by talented graduate student Chuanping Zhao. nature.com/articles/s4146…
We found that endogenous ligand for GPR139 is opioid peptide dynorphin. With this, GPR139 may not be an orphan any more but the 5th opioid receptor. Heavy lift by talented Xiaona Li with great thanks to all who contributed! nature.com/articles/s4146…
Wow!!!
Excited to present our preprint on the structure-function relationship of anaphylatoxin complement receptors. A casual number of 19 structures deciphering ligand recognition mechanisms, G protein/arrestin and species specific signaling. Check it out! biorxiv.org/content/biorxi…
The ON/OFF dichotomy is fundamental to visual processing. In a new study led by Flori Soto, we identify a conserved molecular mechanism establishing the OFF pathway. rdcu.be/eikoa
Our latest on GPCR function in the brain. We report that glutamate receptor mGlu4 needs to be properly positioned at synapses of cholinergic interneurons in NAc by cell adhesion molecule ELFN1 to regulate opioid reward. pnas.org/doi/epub/10.10…
A popular FDA-approved drug to treat hypertension, hydralazine works, at least in part, by modulating RGS proteins! Honored to be a part of a collaborative team led by @MegaMatthewsLab! biorxiv.org/content/10.110…
Excited to share our latest on ELFN1 mechanisms, a dysfunction of which leads to a devastating neurodevelopmental disorder. Swan song of @GPCRHenry. #GPCR , #Elfn1, @jbiolchem sciencedirect.com/science/articl…
Happy to introduce DeFrND: designer peptide scaffolds to enable detergent-free reconstitution of membrane proteins with native lipids into nanodiscs for biochemical and structural studies. Let me know if you would like to try it. biorxiv.org/content/10.110…
An amazing paper- a treat to read! Can't be more proud of former postdocs doing awesome science! Go Brian Muntean! pnas.org/doi/10.1073/pn…
As shown recently a single point mutation in G protein alpha subunit yields a stable complex without the use of stabilizing nanobodies! nature.com/articles/s4146…
Spot on!
A few postdocs asked me to read over their job applications. Here’s a few bits of advice: 🧵 /10 1. If any advice doesn’t ring true for you, discard it (including this!) 2. People on the search committee are keen to welcome a colleague, they aren’t looking to take you down
Soluble GPCRs! Check it out! Congrats @befcorreia ! nature.com/articles/s4158…
This is a must read masterclass in sensory circuit dissection and really cool behavioral adaptation!
In a new study led by @mike_fitz23, we describe a pupillary contrast response in mice and humans, which senses temporal contrast to enhance spatial contrast in the retinal image and increase visual acuity. We decipher the underlying neural mechanisms. bit.ly/3w8ieIV
Frizzled receptors are so cool. Consolidated model of GPCR realm with scaffolding signalosome.
Check out our new review in TiPS "Frizzleds act as dynamic pharmacological entities" written with the postdocs in the team: @GraetzLukas @PKozielewicz @MagdalenaScharf @JanVo12 and twitterless Julien Bous. authors.elsevier.com/sd/article/S01…
This is an amazing progress! Breathtaking structure and a cool model!
Check out our new review in TiPS "Frizzleds act as dynamic pharmacological entities" written with the postdocs in the team: @GraetzLukas @PKozielewicz @MagdalenaScharf @JanVo12 and twitterless Julien Bous. authors.elsevier.com/sd/article/S01…
This is a phenomenal paper! Very easy to read and advance is mesmerizing. Highly recommend to folks interested in orphan receptors and their role in totally new biology.
In the latest issue! A gut-derived hormone regulates cholesterol metabolism dlvr.it/T4szX3
Welcome, Ezgi @ezgi_hsuleyman ! Looking forward to working with you!
Welcome @ezgi_hsuleyman, Ph.D., who probes how neurons respond to signals, changing in milliseconds! She's invented a way to inventory their RNA and proteins before and after firing. #neuroscience #RNA #RNAbiology #cellbiology #science #brain wertheim.scripps.ufl.edu/2024/03/26/fir…
@jbiolchem symposium @ASBMB meeting kicked off by @ChiefEditorJBC , and composed by three outstanding talks by editors and scientists @HenrikDohlman @DrBrianStrahl @KLabGPCR.