The Science of Parkinson's
@ScienceofPD
Personal account of the Director of Research at @CureParkinsonsT - All views my own - Kiwi - Kia kaha - 侘寂
As part of Healthy Brain Ageing Kassel study, researchers conducted a stepwise, population-based screening to identify people at high risk of developing #Parkinsons; An online survey with questions for prodromal symptoms, followed by a smell test nature.com/articles/s4153…
☣️🐀 Pesticide exposure in rats changes epigenetic signatures in different brain regions! Latest paper from our fruitful collaboration with Emily Rocha and Tim Greenamyre, linking epigenetic signatures of exposure to toxicants to Parkinson's disease.: nature.com/articles/s4153…
New clinical trial registered: A 104 week multicenter, randomized, double-blind, placebo-controlled clinical study assessing the efficacy of the anti-α-synuclein antibody prasinezumab to slow cognitive decline in 120 people with GBA1-associated #Parkinsons clinicaltrials.gov/study/NCT07055…
New clinical trial registered: The StepuP study: A 12 sessions of treadmill training, with pre/post assessments & a follow-up period of 12±2 weeks for 42 people with #Parkinsons in Australia... mmm, deja vu? clinicaltrials.gov/study/NCT07057…
New clinical trial registered: The StepuP study: A 12 sessions of treadmill training, with pre/post assessments & a follow-up period of 12±2 weeks following for 42 people with #Parkinsons in Kiel clinicaltrials.gov/study/NCT07058…
New clinical trial registered: The PDGSH study - A pilot trial using gamma-glutamylcysteine supplementation in #Parkinsons to enrichment levels of glutathione; N=12, treatment period = 12 months clinicaltrials.gov/study/NCT07064…
New clinical trial registered: SMART-PD: Evaluating the impact of 4-weeks of smartphone-based wearable technology on motor symptoms & quality of life in 32 people with #Parkinsons clinicaltrials.gov/study/NCT07066…
New clinical trial registered: An 8 week, double-blind, placebo-controlled trial in Bangladesh seeks to learn if metformin has any effect on motor aspects of daily living & oxidative stress in 74 people with levodopa-treated #Parkinsons clinicaltrials.gov/study/NCT07055…
Don't tell anyone, but @CureParkinsonsT has a new funding call coming soon... It will focus on projects exploring rationally designed combination therapies for disease modification in #Parkinsons Like I said, don't tell anyone... But put your thinking caps on regarding combos!
A phosphatome-wide siRNA screen by @pfeffersuzanne et al identifies PPM1M as a phosphoRab12-preferring phosphatase that also acts on phosphoRab8A & phosphoRab10; Knockout=cilia loss; PPM1M=key player in the #Parkinsons-associated LRRK2 signaling pathway cell.com/cell-reports/f…
New review explores how #Parkinsons-associated alpha-synuclein fibril structures cluster into distinct groups; "Approximately 100 high-resolution solid-state NMR spectroscopy & cryo-EM structures of Asyn fibrils have been deposited to the Protein Databank" cell.com/biophysj/abstr…
In normal mice, injection of pre-formed fibrils (PFFs), but not monomeric α-synuclein = aggregated α-syn, loss of substantia nigra dopamine neurons & increased neuroinflammation In A53T SNCA mice, both PFFs & monomeric α-synuclein induced this pathology nature.com/articles/s4159…
S.BIOMEDICS announced encouraging one-year post-transplant results from Phase 1/2a clinical trial evaluating A9-DPC cell therapy for #Parkinsons; Favorable safety & efficacy profile of A9-DPC in 12 participants at 12 months compared to baseline manilatimes.net/2025/07/21/tmt…
Researchers at @WEHI_research (led by @DewsonGrant & @komander_lab) announce a strategic partnership with the Aligning Science Across #Parkinsons (ASAP) initiative to fast-track the discovery of new treatments for PD biomelbourne.org/wehi-announces…
New research reports "that the SNAP23, STX4 or RAB8A knockdown-induced blockade of autophagic secretion accelerated α-synuclein proteostasis impairment by pharmacological inhibition of lysosomal proteases"; Blockade of autophagic secretion=cargo overload? jbc.org/article/S0021-…
More preclinical data indicating that the novel GLP-1/GIP dual agonist DA3-CH is more effective than the GLP-1 receptor agonist liraglutide in an MPTP mouse model of #Parkinsons sciencedirect.com/science/articl…
"Transformative neuropathology" - just new terminology, or a "paradigm shift" aiming "to inspire a reimagining of neuropathology’s role in driving innovation & addressing critical challenges in brain disease research" Interesting reading for Monday night cell.com/neuron/fulltex…
Nice editorial in the @TheLancetNeuro on accelerating the path towards a cure for #Parkinsons - the @MichaelJFoxOrg "Targets to Therapies" (T2T) initiative gets a mention, as does the new @AlzResearchUK & @CureParkinsonsT collaboration - lots of activities thelancet.com/journals/laneu…
New review from @groblescristina & colleagues explores neuroprotection in #Parkinsons; "From a clinical point of view, functionally relevant, “dopa-refractory” clinical outcome measures are needed in disease-modifying PD clinical trials" link.springer.com/article/10.100…
New review explores attention/working memory & executive function in #Parkinsons …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…