Horacio Maldonado
@HJMald
Ph.D. in Biochemistry, Cell adhesion molecules and ECM researcher
Excited to share that our latest paper on the crosstalk between integrin αVβ6 and HER2 in HER2+ breast cancer is OUT! @M_MorganLab @LivUniCancer @ScienceAdvances @LivUniISMIB #BreastCancer #Trastuzumab science.org/doi/10.1126/sc…
*Fully funded PhD position available in the lab* We will use structural proteomics to map the mechanosensitive interactions of talin in dendritic spines and how they change during long term potentiation. Please RT, and email/message for details findaphd.com/phds/project/b…
🚀Exciting new review exploring the intersection of #mechanobiology & #AI! From predicting cell forces to analyzing complex genomic data, AI is unlocking new insights into how cells respond to mechanical cues. nature.com/articles/s4434…
Thrilled to share our latest publication! We describe a novel acid-dependent mechanism regulating clathrin-independent endocytosis. This study was a fantastic collaborative effort with the labs of Ludger Johannes, Roberto Weigert, and Satyajit Mayor. nature.com/articles/s4155….
Interested in pexophagy? Check out our newly published work: we developed pexophagy reporters for use in Drosophila research. Very happy to have been involved in this collaboration @LivUniISMIB royalsocietypublishing.org/doi/10.1098/rs…
1/8 🚨 New publication alert! 🚨 We developed live #Drosophila melanogaster models with fluorescent reporters to study #pexophagy – the selective autophagy of peroxisomes – in vivo. 🧵👇 @livuninews @wellcometrust @CCI_liv @LivUniHLS
Look at the amazing speaker list for Adhere2 next September! This is going to be an excellent meeting, in beautiful Zadar, Croatia. event.fourwaves.com/adhere2/pages/…
Very excited to share our latest paper describing crosstalk between αvβ6 integrin & HER2 in breast cancer invasion & drug resistance. Great work by @HJMald & many others science.org/doi/10.1126/sc… @ScienceAdvances @LivUniISMIB @AdamHurlstone Many thanks to @BCCare @NorthWestCancer
Understanding and measuring mechanical signals in the tumor stroma febs.onlinelibrary.wiley.com/doi/10.1002/22…
Free scientific illustrations for biologists! 😍 @NIH has released a library of 500+ free scientific illustrations to create figures, presentations, and illustrations! all freely available in the public domain. Retweet and spread the message! bioart.niaid.nih.gov
Thrilled to announce that our paper, “A trafficking regulatory subnetwork governs αVβ6 Integrin-HER2 crosstalk to control breast cancer invasion and drug resistance,” has been accepted in Science Advances! @M_MorganLab @LivUniCancer #CancerResearch #AVB6INTEGRIN #BreastCancer
After the great success of Adhere1 last September, @ambriovic, @KostourouVasso and myself are excited to announce that Adhere2 will go ahead next September. 3rd-6th September 2025 in beautiful Zadar, Croatia.
Can't wait for Fibronectin, Integrin and Related Molecules (FIRM?) GRC! What a great lineup of speakers - fantastic from @WickstromLab @TanentzapfLab
@WickstromLab & myself are happy to announce the program for the upcoming Fibronectin, Integrin & Related Molecules Gordon Research Conference. This is one of the oldest GRC conferences around (since 1982) & we put together an OUTSTANDING program for y'all. Registration is open.
Check out @IvaskaLab latest unexpected discovery on hyperactivation as a way to kill KRAS mutant cancer cells and limit KRASmut xenograft growth with nanobodies disrupting SHANK3-KRAS interaction 👇
What happens when unexpected happens!? 1) @johannalilja_ @IvaskaLab #JasminKaivola identified SHANK3 as a KRAS inhibitor 2) predicted SHANK3 depletion boosts KRASmut tumors 3) observed SHANK3 depletion kills KRAS-cells by ERK hyperactivation, apoptosis rdcu.be/dTQDP
My commute this morning ☺️ @IvaskaLab in #TheHappiestCountryInTheWorld @BioscienceTurku is starting our @ERC_Research AdG funded project BorderControl on tumor-matrix crosstalk limiting cancer progression. We are looking for postdocs! Pls contact me for more info
September issue of @JCellBiol also contains our new paper on TLNRD1 (talin rod domain containing 1) protein and its role in the Cerebral Cavernous Malformation complex. rupress.org/jcb/article/22… @guijacquemet @LivUniISMIB @biokent @UniTurku
Our September issue is out! hubs.la/Q02N4zdK0 🔬 The cover shows the heart (cardiac tube) of a 20-day old adult #Drosophila stained with phalloidin (red), while adjacent pericardial cells are marked by dorothy-GFP (green). From @gera_jayati et al (hubs.la/Q02N4zxk0)
🚨 We have two exciting group leader opportunities for scholars with a passion for cancer cell biology: one Reader and one Senior Lecturer position. Join us! ➡ Reader: bit.ly/3Mfk3bd ➡ Senior Lecturer: bit.ly/3MgTanf 📆 30.09.24
📢Junior Group Leader positions📢 Call for ECRs looking to establish an independent research programme with CRUK, Wellcome, UKRI, ERC or other fellowship funding within our leading cancer research facilities Find out more and register your interest here: crukscotlandinstitute.ac.uk/careers/group-…
#Cancer metabolism -targeting fatty acid oxidation alongside HER2-targeted therapies to combat resistance in HER2+ #breastcancer #Keto nature.com/articles/s4146… @NatureComms
The Interplay between Extracellular Matrix Remodeling and Cancer Therapeutics aacrjournals.org/cancerdiscover…
Pleased to share our new paper in Science Advances in collab w Schaffer Lab & colleagues from @kaistpr! Spectrin mediates 3D-specific matrix stress-relaxation response in neural stem cell lineage commitment science.org/doi/10.1126/sc…