Mark Morgan's Lab

Very excited to share our latest paper describing crosstalk between αvβ6 integrin & HER2 in breast cancer invasion & drug resistance. Great work by @HJMald & many others science.org/doi/10.1126/sc… @ScienceAdvances @LivUniISMIB @AdamHurlstone Many thanks to @BCCare @NorthWestCancer

NEWS | New insights in breast cancer progression and drug resistance ➡️ bit.ly/3OLKIhb #CancerResearch | #TeamLivUni

Look at the amazing speaker list for Adhere2 next September! This is going to be an excellent meeting, in beautiful Zadar, Croatia. event.fourwaves.com/adhere2/pages/…

5) Components of the trafficking regulatory subnetwork are highly expressed in HER2+ breast cancers expressing high levels of αVβ6.

4) RAB5, RAB7A, and GDI2 differentially regulate invasion and αVβ6 integrin-mediated TGFβ activation, but this mechanism is uncoupled by trastuzumab resistance, rendering cells unresponsive to αVβ6, HER2 or TGFβ-Receptor inhibition.

2) Components of the trafficking regulatory subnetwork mediate direct crosstalk between αVβ6 and HER2, affecting receptor trafficking and signalling. 3) Trastuzumab resistance disrupts αVβ6-mediated control of HER2 endocytosis and signalling.

We show that: 1) Integrin αVβ6 recruits HER2 and a RAB5/RAB7A/GDI2 trafficking regulatory subnetwork. This recruitment is enhanced by exposure to the HER2-trageting drug trastuzumab, but dysregulated following acquired trastuzumab resistance.

Very excited to share our new paper on Talin binding to Amyloid Precursor Protein indicating a new way to think about Alzheimer's Disease. It has the most provocative discussion section we have ever written :) royalsocietypublishing.org/doi/10.1098/rs…

Excited to share that our latest paper on the crosstalk between integrin αVβ6 and HER2 in HER2+ breast cancer is OUT! @M_MorganLab @LivUniCancer @ScienceAdvances @LivUniISMIB #BreastCancer #Trastuzumab science.org/doi/10.1126/sc…

Great to meet you face to face for the first time @M_MorganLab & thank you for a great talk @LivCancerRes #LCR121! So much opportunity for #collaboration in tumour micro-environment and #immuno-oncology studies across @LivUniISMIB @livuniHLS @livuninews @LivHPartners

Dr Muhammad Awais from @LivUniCancer brought pancreatic research to Liverpool College for a Role Model Day👩‍🔬encouraging year 5 pupils to consider a career in science! Lab coats & origami added fun and culture to the day🥼tinyurl.com/2m45xpc9